Advances in Nanogels for Topical Drug Delivery in Ocular Diseases
Nanotechnology has accelerated the development of the pharmaceutical and medical technology fields, and nanogels for ocular applications have proven to be a promising therapeutic strategy. Traditional ocular preparations are restricted by the anatomical and physiological barriers of the eye, resulti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/9/4/292 |
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| author | Yongkang Wu Qing Tao Jing Xie Lili Lu Xiuli Xie Yang Zhang Yong Jin |
| author_facet | Yongkang Wu Qing Tao Jing Xie Lili Lu Xiuli Xie Yang Zhang Yong Jin |
| author_sort | Yongkang Wu |
| collection | DOAJ |
| description | Nanotechnology has accelerated the development of the pharmaceutical and medical technology fields, and nanogels for ocular applications have proven to be a promising therapeutic strategy. Traditional ocular preparations are restricted by the anatomical and physiological barriers of the eye, resulting in a short retention time and low drug bioavailability, which is a significant challenge for physicians, patients, and pharmacists. Nanogels, however, have the ability to encapsulate drugs within three-dimensional crosslinked polymeric networks and, through specific structural designs and distinct methods of preparation, achieve the controlled and sustained delivery of loaded drugs, increasing patient compliance and therapeutic efficiency. In addition, nanogels have higher drug-loading capacity and biocompatibility than other nanocarriers. In this review, the main focus is on the applications of nanogels for ocular diseases, whose preparations and stimuli-responsive behaviors are briefly described. The current comprehension of topical drug delivery will be improved by focusing on the advances of nanogels in typical ocular diseases, including glaucoma, cataracts, dry eye syndrome, and bacterial keratitis, as well as related drug-loaded contact lenses and natural active substances. |
| first_indexed | 2024-03-11T05:00:32Z |
| format | Article |
| id | doaj.art-d4580d1762a44bcbbcd06c04ee2964f3 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-11T05:00:32Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-d4580d1762a44bcbbcd06c04ee2964f32023-11-17T19:21:23ZengMDPI AGGels2310-28612023-04-019429210.3390/gels9040292Advances in Nanogels for Topical Drug Delivery in Ocular DiseasesYongkang Wu0Qing Tao1Jing Xie2Lili Lu3Xiuli Xie4Yang Zhang5Yong Jin6School of Pharmacy, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei 230032, ChinaSchool of Pharmacy, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei 230032, ChinaSchool of Pharmacy, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei 230032, ChinaSchool of Pharmacy, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei 230032, ChinaSchool of Pharmacy, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei 230032, ChinaSchool of Pharmacy, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei 230032, ChinaSchool of Pharmacy, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei 230032, ChinaNanotechnology has accelerated the development of the pharmaceutical and medical technology fields, and nanogels for ocular applications have proven to be a promising therapeutic strategy. Traditional ocular preparations are restricted by the anatomical and physiological barriers of the eye, resulting in a short retention time and low drug bioavailability, which is a significant challenge for physicians, patients, and pharmacists. Nanogels, however, have the ability to encapsulate drugs within three-dimensional crosslinked polymeric networks and, through specific structural designs and distinct methods of preparation, achieve the controlled and sustained delivery of loaded drugs, increasing patient compliance and therapeutic efficiency. In addition, nanogels have higher drug-loading capacity and biocompatibility than other nanocarriers. In this review, the main focus is on the applications of nanogels for ocular diseases, whose preparations and stimuli-responsive behaviors are briefly described. The current comprehension of topical drug delivery will be improved by focusing on the advances of nanogels in typical ocular diseases, including glaucoma, cataracts, dry eye syndrome, and bacterial keratitis, as well as related drug-loaded contact lenses and natural active substances.https://www.mdpi.com/2310-2861/9/4/292nanogelsocular diseasesdrug delivery systemsnatural polymerscontact lenses |
| spellingShingle | Yongkang Wu Qing Tao Jing Xie Lili Lu Xiuli Xie Yang Zhang Yong Jin Advances in Nanogels for Topical Drug Delivery in Ocular Diseases Gels nanogels ocular diseases drug delivery systems natural polymers contact lenses |
| title | Advances in Nanogels for Topical Drug Delivery in Ocular Diseases |
| title_full | Advances in Nanogels for Topical Drug Delivery in Ocular Diseases |
| title_fullStr | Advances in Nanogels for Topical Drug Delivery in Ocular Diseases |
| title_full_unstemmed | Advances in Nanogels for Topical Drug Delivery in Ocular Diseases |
| title_short | Advances in Nanogels for Topical Drug Delivery in Ocular Diseases |
| title_sort | advances in nanogels for topical drug delivery in ocular diseases |
| topic | nanogels ocular diseases drug delivery systems natural polymers contact lenses |
| url | https://www.mdpi.com/2310-2861/9/4/292 |
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