Antiaging and antioxidative effects of water extract of Zizyphus jujuba Mill on Caenorhabditis elegans
Zizyphus jujuba Mill is a typical food-medicine homology in China, and the adage of “three jujubes a day, longevity” highlights its potential antiaging properties. However, its antiaging effect and mechanism have been poorly explored. In this study, Caenorhabditis elegans was utilized to investigate...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623004292 |
| _version_ | 1797632728246517760 |
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| author | Zhiying Hou Deqi Zhu Xinchang Gao Li Zhao Hui Yang Qiong Wang Yufen Zhao Ning Wang |
| author_facet | Zhiying Hou Deqi Zhu Xinchang Gao Li Zhao Hui Yang Qiong Wang Yufen Zhao Ning Wang |
| author_sort | Zhiying Hou |
| collection | DOAJ |
| description | Zizyphus jujuba Mill is a typical food-medicine homology in China, and the adage of “three jujubes a day, longevity” highlights its potential antiaging properties. However, its antiaging effect and mechanism have been poorly explored. In this study, Caenorhabditis elegans was utilized to investigate the antiaging effects and underlying mechanisms of the active components of jujube water extract (ZJME). We discovered that ZJME is rich in polysaccharides (264.15 mg/g), polyphenols (9.29 mg/g), cAMP and other components with antioxidant effects. ZJME significantly prolonged the average and maximum lifespan (31 % and 14 %) of nematodes under oxidative stress conditions. ZJME reduced the release of ROS and RNS by 44 % and 22 %, and increased the activity of the antioxidant enzymes SOD by 18 % (P < 0.01) and CAT by 55 % (P < 0.05). qRT-PCR analysis revealed that ZJME regulated the AMPK and MAPK pathway while inhibiting the IIS pathway to enhance the antioxidant defense system. |
| first_indexed | 2024-03-11T11:41:54Z |
| format | Article |
| id | doaj.art-d45af8f09b9d44dc828ac405497dcade |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-11T11:41:54Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-d45af8f09b9d44dc828ac405497dcade2023-11-10T04:16:09ZengElsevierJournal of Functional Foods1756-46462023-11-01110105829Antiaging and antioxidative effects of water extract of Zizyphus jujuba Mill on Caenorhabditis elegansZhiying Hou0Deqi Zhu1Xinchang Gao2Li Zhao3Hui Yang4Qiong Wang5Yufen Zhao6Ning Wang7Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, ChinaInstitute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, ChinaInstitute of Drug Discovery Technology, Ningbo University, Ningbo 315211, ChinaInstitute of Drug Discovery Technology, Ningbo University, Ningbo 315211, ChinaInstitute of Drug Discovery Technology, Ningbo University, Ningbo 315211, ChinaInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China; Sino-Portugal TCM International Cooperation Center, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, ChinaInstitute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China; Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo 315211, China; Corresponding authors at: Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China.Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China; Corresponding authors at: Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China.Zizyphus jujuba Mill is a typical food-medicine homology in China, and the adage of “three jujubes a day, longevity” highlights its potential antiaging properties. However, its antiaging effect and mechanism have been poorly explored. In this study, Caenorhabditis elegans was utilized to investigate the antiaging effects and underlying mechanisms of the active components of jujube water extract (ZJME). We discovered that ZJME is rich in polysaccharides (264.15 mg/g), polyphenols (9.29 mg/g), cAMP and other components with antioxidant effects. ZJME significantly prolonged the average and maximum lifespan (31 % and 14 %) of nematodes under oxidative stress conditions. ZJME reduced the release of ROS and RNS by 44 % and 22 %, and increased the activity of the antioxidant enzymes SOD by 18 % (P < 0.01) and CAT by 55 % (P < 0.05). qRT-PCR analysis revealed that ZJME regulated the AMPK and MAPK pathway while inhibiting the IIS pathway to enhance the antioxidant defense system.http://www.sciencedirect.com/science/article/pii/S1756464623004292Zizyphus jujuba MillC. elegansAntiagingAntioxidantAMPK/MAPK/IIS signaling pathways |
| spellingShingle | Zhiying Hou Deqi Zhu Xinchang Gao Li Zhao Hui Yang Qiong Wang Yufen Zhao Ning Wang Antiaging and antioxidative effects of water extract of Zizyphus jujuba Mill on Caenorhabditis elegans Journal of Functional Foods Zizyphus jujuba Mill C. elegans Antiaging Antioxidant AMPK/MAPK/IIS signaling pathways |
| title | Antiaging and antioxidative effects of water extract of Zizyphus jujuba Mill on Caenorhabditis elegans |
| title_full | Antiaging and antioxidative effects of water extract of Zizyphus jujuba Mill on Caenorhabditis elegans |
| title_fullStr | Antiaging and antioxidative effects of water extract of Zizyphus jujuba Mill on Caenorhabditis elegans |
| title_full_unstemmed | Antiaging and antioxidative effects of water extract of Zizyphus jujuba Mill on Caenorhabditis elegans |
| title_short | Antiaging and antioxidative effects of water extract of Zizyphus jujuba Mill on Caenorhabditis elegans |
| title_sort | antiaging and antioxidative effects of water extract of zizyphus jujuba mill on caenorhabditis elegans |
| topic | Zizyphus jujuba Mill C. elegans Antiaging Antioxidant AMPK/MAPK/IIS signaling pathways |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623004292 |
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