Medical Prospect of Melatonin in the Intervertebral Disc Degeneration through Inhibiting M1-Type Macrophage Polarization via SIRT1/Notch Signaling Pathway

Medical Prospect of Melatonin in the Intervertebral Disc Degeneration through Inhibiting M1-Type Macrophage Polarization via SIRT1/Notch Signaling Pathway

The study aims to explore the medical prospect of melatonin (MLT) and the underlying therapeutic mechanism of MLT-mediated macrophage (Mφ) polarization on the function of nucleus pulposus (NP) in intervertebral disc degeneration (IDD). RAW 264.7 Mφs were induced by lipopolysaccharide (LPS) to simula...

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Bibliographic Details
Main Authors: Xinyu Dou, Qipeng Luo, Linzhen Xie, Xuchang Zhou, Chunyu Song, Meijuan Liu, Xiao Liu, Yunlong Ma, Xiaoguang Liu
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Biomedicines
Subjects:
melatonin
intervertebral disc degeneration
macrophage polarization
nucleus pulposus cell
SIRT1/Notch signaling pathway
Online Access:https://www.mdpi.com/2227-9059/11/6/1615

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