| Summary: | Metal oxide nanoparticles synthesized by the biological method represent the most recent research in nanotechnology. This study reports the rapid and ecofriendly approach for the synthesis of CeO<sub>2</sub> nanoparticles mediated using the <i>Abelmoschus esculentus</i> extract. The medicinal plant extract acts as both a reducing and stabilizing agent. The characterization of CeO<sub>2</sub> NPs was performed by scanning electron microscopy (SEM), X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV-Vis), and Fourier transform infrared spectroscopy (FTIR). The in vitro cytotoxicity of green synthesized CeO<sub>2</sub> was assessed against cervical cancerous cells (HeLa). The exposure of CeO<sub>2</sub> to HeLa cells at 10–125 µg/mL caused a loss in cellular viability against cervical cancerous cells in a dose-dependent manner. The antibacterial activity of the CeO<sub>2</sub> was assessed against <i>S. aureus</i> and <i>K. pneumonia</i>. A significant improvement in wound-healing progression was observed when cerium oxide nanoparticles were incorporated into the chitosan hydrogel membrane as a wound dressing.
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