G Protein-coupled receptors as targets for drug design
G protein-coupled receptors (GPCRs) are the target for more than 50% of the drugs currently on the market, including about 25% of the 100 top-selling drugs. They are considered the most important molecules in the field of drug discovery and design today, mostly due to their role as receptors in many...
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| Format: | Article |
| Language: | English |
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Elfos Scientiae
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| Series: | Biotecnología Aplicada |
| Subjects: | |
| Online Access: | http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522009000100003&lng=en&tlng=en |
| _version_ | 1818032563245023232 |
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| author | Ania de la Nuez Veulens Rolando Rodríguez |
| author_facet | Ania de la Nuez Veulens Rolando Rodríguez |
| author_sort | Ania de la Nuez Veulens |
| collection | DOAJ |
| description | G protein-coupled receptors (GPCRs) are the target for more than 50% of the drugs currently on the market, including about 25% of the 100 top-selling drugs. They are considered the most important molecules in the field of drug discovery and design today, mostly due to their role as receptors in many of the basic processes in the body, and because they are present in all tissues. Unfortunately, a structure-based rational design is very difficult for GPCRs; the structures available for modeling purposes are only for family A. Despite this fact, research has continued and progressed, using combined structure-based techniques. This review intends to summarize this work. |
| first_indexed | 2024-12-10T06:09:21Z |
| format | Article |
| id | doaj.art-d45f4daf2d9c4b20acb2637ee2233495 |
| institution | Directory Open Access Journal |
| issn | 1027-2852 |
| language | English |
| last_indexed | 2024-12-10T06:09:21Z |
| publisher | Elfos Scientiae |
| record_format | Article |
| series | Biotecnología Aplicada |
| spelling | doaj.art-d45f4daf2d9c4b20acb2637ee22334952022-12-22T01:59:36ZengElfos ScientiaeBiotecnología Aplicada1027-28522612433S1027-28522009000100003G Protein-coupled receptors as targets for drug designAnia de la Nuez Veulens0Rolando Rodríguez1Centro de Ingeniería Genética y BiotecnologíaCentro de Ingeniería Genética y BiotecnologíaG protein-coupled receptors (GPCRs) are the target for more than 50% of the drugs currently on the market, including about 25% of the 100 top-selling drugs. They are considered the most important molecules in the field of drug discovery and design today, mostly due to their role as receptors in many of the basic processes in the body, and because they are present in all tissues. Unfortunately, a structure-based rational design is very difficult for GPCRs; the structures available for modeling purposes are only for family A. Despite this fact, research has continued and progressed, using combined structure-based techniques. This review intends to summarize this work.http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522009000100003&lng=en&tlng=engpcr7tmevaluación virtualacoplamiento molecularmodelación moleculardiseño de fármacos |
| spellingShingle | Ania de la Nuez Veulens Rolando Rodríguez G Protein-coupled receptors as targets for drug design Biotecnología Aplicada gpcr 7tm evaluación virtual acoplamiento molecular modelación molecular diseño de fármacos |
| title | G Protein-coupled receptors as targets for drug design |
| title_full | G Protein-coupled receptors as targets for drug design |
| title_fullStr | G Protein-coupled receptors as targets for drug design |
| title_full_unstemmed | G Protein-coupled receptors as targets for drug design |
| title_short | G Protein-coupled receptors as targets for drug design |
| title_sort | g protein coupled receptors as targets for drug design |
| topic | gpcr 7tm evaluación virtual acoplamiento molecular modelación molecular diseño de fármacos |
| url | http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522009000100003&lng=en&tlng=en |
| work_keys_str_mv | AT aniadelanuezveulens gproteincoupledreceptorsastargetsfordrugdesign AT rolandorodriguez gproteincoupledreceptorsastargetsfordrugdesign |