Alteration of prognostic efficacy of albumin‐bilirubin grade and Child‐Pugh score according to liver fibrosis in hepatocellular carcinoma patients with Child‐Pugh A following hepatectomy
Abstract Background The albumin‐bilirubin (ALBI) grade was developed to predict the prognosis of patients with hepatocellular carcinoma (HCC), which can stratify the prognosis even in HCC patients with Child‐Pugh A. We evaluated the prognostic efficacy of the ALBI grade and Child‐Pugh classification...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Annals of Gastroenterological Surgery |
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| Online Access: | https://doi.org/10.1002/ags3.12498 |
| _version_ | 1818952559709126656 |
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| author | Tatsunori Miyata Yo‐ichi Yamashita Kota Arima Takaaki Higashi Hiromitsu Hayashi Katsunori Imai Hidetoshi Nitta Akira Chikamoto Toru Beppu Hideo Baba |
| author_facet | Tatsunori Miyata Yo‐ichi Yamashita Kota Arima Takaaki Higashi Hiromitsu Hayashi Katsunori Imai Hidetoshi Nitta Akira Chikamoto Toru Beppu Hideo Baba |
| author_sort | Tatsunori Miyata |
| collection | DOAJ |
| description | Abstract Background The albumin‐bilirubin (ALBI) grade was developed to predict the prognosis of patients with hepatocellular carcinoma (HCC), which can stratify the prognosis even in HCC patients with Child‐Pugh A. We evaluated the prognostic efficacy of the ALBI grade and Child‐Pugh classification in HCC patients with Child‐Pugh A stratified by the presence or absence of advanced fibrosis or a preoperative biomarker for advanced fibrosis. Methods We retrospectively analyzed 490 consecutive HCC patients with Child‐Pugh A who underwent initial hepatectomies. The accuracy of prognostic prediction using both models was compared by the presence or absence of advanced fibrosis (F3‐4) and its predictor, the preoperative platelet count (PLT). Results The prognostic accuracy of the ALBI grade was better in patients without advanced fibrosis (F3‐4; likelihood ratio: 4.39, corrected Akaike information criterion [AICc]: 453.0, P = .074), but Child‐Pugh score was better in the advanced fibrosis group (likelihood ratio: 10.67, AICc: 915.2, P = .0014). In the high PLT group (≥140 × 103/μL), the prognostic accuracy using the ALBI grade was better in overall survival (OS) and relapse‐free survival (RFS), but in the low PLT group, the Child‐Pugh score was the more accurate model in OS and RFS. Conclusions Depending on the degree of fibrosis or preoperative PLT, the ALBI grade and Child‐Pugh score may provide more accurate prognoses after initial hepatectomy in HCC patients with Child‐Pugh A. |
| first_indexed | 2024-12-20T09:52:18Z |
| format | Article |
| id | doaj.art-d460b3fec0834a93832e0aa72483a38b |
| institution | Directory Open Access Journal |
| issn | 2475-0328 |
| language | English |
| last_indexed | 2024-12-20T09:52:18Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Gastroenterological Surgery |
| spelling | doaj.art-d460b3fec0834a93832e0aa72483a38b2022-12-21T19:44:33ZengWileyAnnals of Gastroenterological Surgery2475-03282022-01-016112713410.1002/ags3.12498Alteration of prognostic efficacy of albumin‐bilirubin grade and Child‐Pugh score according to liver fibrosis in hepatocellular carcinoma patients with Child‐Pugh A following hepatectomyTatsunori Miyata0Yo‐ichi Yamashita1Kota Arima2Takaaki Higashi3Hiromitsu Hayashi4Katsunori Imai5Hidetoshi Nitta6Akira Chikamoto7Toru Beppu8Hideo Baba9Department of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto JapanDepartment of Surgery Saiseikai Kumamoto Hospital Kumamoto JapanDepartment of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto JapanAbstract Background The albumin‐bilirubin (ALBI) grade was developed to predict the prognosis of patients with hepatocellular carcinoma (HCC), which can stratify the prognosis even in HCC patients with Child‐Pugh A. We evaluated the prognostic efficacy of the ALBI grade and Child‐Pugh classification in HCC patients with Child‐Pugh A stratified by the presence or absence of advanced fibrosis or a preoperative biomarker for advanced fibrosis. Methods We retrospectively analyzed 490 consecutive HCC patients with Child‐Pugh A who underwent initial hepatectomies. The accuracy of prognostic prediction using both models was compared by the presence or absence of advanced fibrosis (F3‐4) and its predictor, the preoperative platelet count (PLT). Results The prognostic accuracy of the ALBI grade was better in patients without advanced fibrosis (F3‐4; likelihood ratio: 4.39, corrected Akaike information criterion [AICc]: 453.0, P = .074), but Child‐Pugh score was better in the advanced fibrosis group (likelihood ratio: 10.67, AICc: 915.2, P = .0014). In the high PLT group (≥140 × 103/μL), the prognostic accuracy using the ALBI grade was better in overall survival (OS) and relapse‐free survival (RFS), but in the low PLT group, the Child‐Pugh score was the more accurate model in OS and RFS. Conclusions Depending on the degree of fibrosis or preoperative PLT, the ALBI grade and Child‐Pugh score may provide more accurate prognoses after initial hepatectomy in HCC patients with Child‐Pugh A.https://doi.org/10.1002/ags3.12498advanced fibrosisChild‐Pugh scoreHCCprognosisThe ALBI grade |
| spellingShingle | Tatsunori Miyata Yo‐ichi Yamashita Kota Arima Takaaki Higashi Hiromitsu Hayashi Katsunori Imai Hidetoshi Nitta Akira Chikamoto Toru Beppu Hideo Baba Alteration of prognostic efficacy of albumin‐bilirubin grade and Child‐Pugh score according to liver fibrosis in hepatocellular carcinoma patients with Child‐Pugh A following hepatectomy Annals of Gastroenterological Surgery advanced fibrosis Child‐Pugh score HCC prognosis The ALBI grade |
| title | Alteration of prognostic efficacy of albumin‐bilirubin grade and Child‐Pugh score according to liver fibrosis in hepatocellular carcinoma patients with Child‐Pugh A following hepatectomy |
| title_full | Alteration of prognostic efficacy of albumin‐bilirubin grade and Child‐Pugh score according to liver fibrosis in hepatocellular carcinoma patients with Child‐Pugh A following hepatectomy |
| title_fullStr | Alteration of prognostic efficacy of albumin‐bilirubin grade and Child‐Pugh score according to liver fibrosis in hepatocellular carcinoma patients with Child‐Pugh A following hepatectomy |
| title_full_unstemmed | Alteration of prognostic efficacy of albumin‐bilirubin grade and Child‐Pugh score according to liver fibrosis in hepatocellular carcinoma patients with Child‐Pugh A following hepatectomy |
| title_short | Alteration of prognostic efficacy of albumin‐bilirubin grade and Child‐Pugh score according to liver fibrosis in hepatocellular carcinoma patients with Child‐Pugh A following hepatectomy |
| title_sort | alteration of prognostic efficacy of albumin bilirubin grade and child pugh score according to liver fibrosis in hepatocellular carcinoma patients with child pugh a following hepatectomy |
| topic | advanced fibrosis Child‐Pugh score HCC prognosis The ALBI grade |
| url | https://doi.org/10.1002/ags3.12498 |
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