In silico analysis of the solute carrier (SLC) family in cancer indicates a link among DNA methylation, metabolic adaptation, drug response, and immune reactivity

In silico analysis of the solute carrier (SLC) family in cancer indicates a link among DNA methylation, metabolic adaptation, drug response, and immune reactivity

Introduction: The oncogenic transformation is driven by genetic and epigenetic alterations influencing cancer cell fate. These alterations also result in metabolic reprogramming by modulating the expression of membrane Solute Carrier (SLC) transporters involved in biomolecules trafficking. SLCs act...

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Bibliographic Details
Main Authors: Alessandro Lavoro, Luca Falzone, Barbara Tomasello, Giuseppe Nicolò Conti, Massimo Libra, Saverio Candido
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
cancer
TCGA
DNA methylation
epigenetics
solute carrier
SLCs
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1191262/full

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