Application value and challenge of traditional Chinese medicine carried by ZIF‐8 in the therapy of ischemic stroke
Abstract Stroke is a group of major diseases that cause death or disability in adults, with high incidence and lack of available therapeutic strategies. Although traditional Chinese medicine (TCM) has continuously achieved good effects in the therapy of stroke while there is still not convincing due...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2021-12-01
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| Series: | Ibrain |
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| Online Access: | https://doi.org/10.1002/ibra.12007 |
| _version_ | 1811328368039165952 |
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| author | Xiao‐Xi Zhu Dong‐Fen Guo Ming Chen Xiao‐Qiong An Bi Wang Wen‐Feng Yu |
| author_facet | Xiao‐Xi Zhu Dong‐Fen Guo Ming Chen Xiao‐Qiong An Bi Wang Wen‐Feng Yu |
| author_sort | Xiao‐Xi Zhu |
| collection | DOAJ |
| description | Abstract Stroke is a group of major diseases that cause death or disability in adults, with high incidence and lack of available therapeutic strategies. Although traditional Chinese medicine (TCM) has continuously achieved good effects in the therapy of stroke while there is still not convincing due to the limitation of blood–brain permeability, as well as the individual differences in usage and dosage. With the improvement of nanotechnology, TCM nanopreparation has gradually become a research hotspot in various fields due to its advantages in permeating the blood–brain barrier, targeting delivery, enhancing sustained‐release drug delivery, changing the distribution in the body, and improving bioavailability. Zeolitic imidazolate framework‐8 (ZIF‐8) is an ideal nano‐drug delivery system for adsorption, catalysis, and drug loading, which is a biocompatible metal–organic framework framed by 2‐methylimidazole and zinc ions. At present, ZIF‐8 was wildly used in the treatment of ischemic stroke. However, challenges remain persists for its clinical application, such as preparation technology, detection technology in vivo, targeting specificity, safety and stability, and so forth. Therefore, more efforts need to overcome the above problems to develop the application of TCM nanopreparations in the therapy of ischemia/reperfusion in the future. |
| first_indexed | 2024-04-13T15:24:54Z |
| format | Article |
| id | doaj.art-d46388bb52354b05a2f1799a6eb10ba9 |
| institution | Directory Open Access Journal |
| issn | 2769-2795 |
| language | English |
| last_indexed | 2024-04-13T15:24:54Z |
| publishDate | 2021-12-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Ibrain |
| spelling | doaj.art-d46388bb52354b05a2f1799a6eb10ba92022-12-22T02:41:33ZengWiley-VCHIbrain2769-27952021-12-017433735010.1002/ibra.12007Application value and challenge of traditional Chinese medicine carried by ZIF‐8 in the therapy of ischemic strokeXiao‐Xi Zhu0Dong‐Fen Guo1Ming Chen2Xiao‐Qiong An3Bi Wang4Wen‐Feng Yu5Key Laboratory of Molecular Biology Guizhou Medical University Guiyang Guizhou ChinaKey Laboratory of Molecular Biology Guizhou Medical University Guiyang Guizhou ChinaKey Laboratory of Molecular Biology Guizhou Medical University Guiyang Guizhou ChinaKey Laboratory of Molecular Biology Guizhou Medical University Guiyang Guizhou ChinaKey Laboratory of Molecular Biology Guizhou Medical University Guiyang Guizhou ChinaKey Laboratory of Molecular Biology Guizhou Medical University Guiyang Guizhou ChinaAbstract Stroke is a group of major diseases that cause death or disability in adults, with high incidence and lack of available therapeutic strategies. Although traditional Chinese medicine (TCM) has continuously achieved good effects in the therapy of stroke while there is still not convincing due to the limitation of blood–brain permeability, as well as the individual differences in usage and dosage. With the improvement of nanotechnology, TCM nanopreparation has gradually become a research hotspot in various fields due to its advantages in permeating the blood–brain barrier, targeting delivery, enhancing sustained‐release drug delivery, changing the distribution in the body, and improving bioavailability. Zeolitic imidazolate framework‐8 (ZIF‐8) is an ideal nano‐drug delivery system for adsorption, catalysis, and drug loading, which is a biocompatible metal–organic framework framed by 2‐methylimidazole and zinc ions. At present, ZIF‐8 was wildly used in the treatment of ischemic stroke. However, challenges remain persists for its clinical application, such as preparation technology, detection technology in vivo, targeting specificity, safety and stability, and so forth. Therefore, more efforts need to overcome the above problems to develop the application of TCM nanopreparations in the therapy of ischemia/reperfusion in the future.https://doi.org/10.1002/ibra.12007ischemic strokenanopreparationtraditional Chinese medicinezeolitic imidazolate framework‐8 |
| spellingShingle | Xiao‐Xi Zhu Dong‐Fen Guo Ming Chen Xiao‐Qiong An Bi Wang Wen‐Feng Yu Application value and challenge of traditional Chinese medicine carried by ZIF‐8 in the therapy of ischemic stroke Ibrain ischemic stroke nanopreparation traditional Chinese medicine zeolitic imidazolate framework‐8 |
| title | Application value and challenge of traditional Chinese medicine carried by ZIF‐8 in the therapy of ischemic stroke |
| title_full | Application value and challenge of traditional Chinese medicine carried by ZIF‐8 in the therapy of ischemic stroke |
| title_fullStr | Application value and challenge of traditional Chinese medicine carried by ZIF‐8 in the therapy of ischemic stroke |
| title_full_unstemmed | Application value and challenge of traditional Chinese medicine carried by ZIF‐8 in the therapy of ischemic stroke |
| title_short | Application value and challenge of traditional Chinese medicine carried by ZIF‐8 in the therapy of ischemic stroke |
| title_sort | application value and challenge of traditional chinese medicine carried by zif 8 in the therapy of ischemic stroke |
| topic | ischemic stroke nanopreparation traditional Chinese medicine zeolitic imidazolate framework‐8 |
| url | https://doi.org/10.1002/ibra.12007 |
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