Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults.
Reduced levels of melatonin have been associated with severe depression. The aim was to investigate the correlation between salivary melatonin and dimensional measures of depressive symptom severity in young adult psychiatric patients. Levels of melatonin were analyzed in six saliva samples during w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4820122?pdf=render |
| _version_ | 1811193980834021376 |
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| author | Isak Sundberg Mia Ramklint Mats Stridsberg Fotios C Papadopoulos Lisa Ekselius Janet L Cunningham |
| author_facet | Isak Sundberg Mia Ramklint Mats Stridsberg Fotios C Papadopoulos Lisa Ekselius Janet L Cunningham |
| author_sort | Isak Sundberg |
| collection | DOAJ |
| description | Reduced levels of melatonin have been associated with severe depression. The aim was to investigate the correlation between salivary melatonin and dimensional measures of depressive symptom severity in young adult psychiatric patients. Levels of melatonin were analyzed in six saliva samples during waking hours from 119 young adult patients under outpatient psychiatric care. Melatonin levels were tested for association with the severity of depressive symptoms using the self-rating version of the Montgomery Åsberg Depression Rating Scale (MADRS-S). Where possible, depressive symptoms were assessed again after 6±2 months of treatment. Response was defined as decrease in MADRS-S by ≥50% between baseline and follow-up. Patients with levels of melatonin in the lowest quartile at bedtime had an increased probability of a high MADRS-S score compared to those with the highest levels of melatonin (odds ratio 1.39, 95% CI 1.15-1.69, p<0.01). A post hoc regression analysis found that bedtime melatonin levels predicted response (odds ratio 4.4, 95% CI 1.06-18.43, p<0.05). A negative relationship between salivary melatonin and dimensional measures of depressive symptom severity was found in young patients under outpatient psychiatric care. Bedtime salivary melatonin levels may have prognostic implications. |
| first_indexed | 2024-04-12T00:18:28Z |
| format | Article |
| id | doaj.art-d4696edc5de140db9824acab249444cf |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T00:18:28Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d4696edc5de140db9824acab249444cf2022-12-22T03:55:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01114e015281410.1371/journal.pone.0152814Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults.Isak SundbergMia RamklintMats StridsbergFotios C PapadopoulosLisa EkseliusJanet L CunninghamReduced levels of melatonin have been associated with severe depression. The aim was to investigate the correlation between salivary melatonin and dimensional measures of depressive symptom severity in young adult psychiatric patients. Levels of melatonin were analyzed in six saliva samples during waking hours from 119 young adult patients under outpatient psychiatric care. Melatonin levels were tested for association with the severity of depressive symptoms using the self-rating version of the Montgomery Åsberg Depression Rating Scale (MADRS-S). Where possible, depressive symptoms were assessed again after 6±2 months of treatment. Response was defined as decrease in MADRS-S by ≥50% between baseline and follow-up. Patients with levels of melatonin in the lowest quartile at bedtime had an increased probability of a high MADRS-S score compared to those with the highest levels of melatonin (odds ratio 1.39, 95% CI 1.15-1.69, p<0.01). A post hoc regression analysis found that bedtime melatonin levels predicted response (odds ratio 4.4, 95% CI 1.06-18.43, p<0.05). A negative relationship between salivary melatonin and dimensional measures of depressive symptom severity was found in young patients under outpatient psychiatric care. Bedtime salivary melatonin levels may have prognostic implications.http://europepmc.org/articles/PMC4820122?pdf=render |
| spellingShingle | Isak Sundberg Mia Ramklint Mats Stridsberg Fotios C Papadopoulos Lisa Ekselius Janet L Cunningham Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults. PLoS ONE |
| title | Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults. |
| title_full | Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults. |
| title_fullStr | Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults. |
| title_full_unstemmed | Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults. |
| title_short | Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults. |
| title_sort | salivary melatonin in relation to depressive symptom severity in young adults |
| url | http://europepmc.org/articles/PMC4820122?pdf=render |
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