Evaluation of Potential In Vitro Recombination Events in Codon Deoptimized FMDV Strains

Evaluation of Potential In Vitro Recombination Events in Codon Deoptimized FMDV Strains

Codon deoptimization (CD) has been recently used as a possible strategy to derive foot-and-mouth disease (FMD) live-attenuated vaccine (LAV) candidates containing DIVA markers. However, reversion to virulence, or loss of DIVA, from possible recombination with wild-type (WT) strains has yet to be ana...

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Bibliographic Details
Main Authors: Edward Spinard, Ian Fish, Paul A. Azzinaro, Monica Rodriguez-Calzada, Ethan J. Hartwig, George R. Smoliga, Aishwarya Mogulothu, Jonathan Arzt, Teresa de los Santos, Gisselle N. Medina
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Viruses
Subjects:
foot-and-mouth disease
FMDV
recombination
codon deoptimization
Online Access:https://www.mdpi.com/1999-4915/15/3/670

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