Advancing CAR-based immunotherapies in solid tumors: CAR- macrophages and neutrophils
Macrophages and neutrophils are the main components of the innate immune system and play important roles in promoting angiogenesis, extracellular matrix remodeling, cancer cell proliferation, and metastasis in the tumor microenvironment (TME). They can also be harnessed to mediate cytotoxic tumor ki...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1291619/full |
| _version_ | 1827631517249044480 |
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| author | Yanling Liang Yanling Liang Qumiao Xu Qumiao Xu Qianqian Gao |
| author_facet | Yanling Liang Yanling Liang Qumiao Xu Qumiao Xu Qianqian Gao |
| author_sort | Yanling Liang |
| collection | DOAJ |
| description | Macrophages and neutrophils are the main components of the innate immune system and play important roles in promoting angiogenesis, extracellular matrix remodeling, cancer cell proliferation, and metastasis in the tumor microenvironment (TME). They can also be harnessed to mediate cytotoxic tumor killing effects and orchestrate effective anti-tumor immune responses with proper stimulation and modification. Therefore, macrophages and neutrophils have strong potential in cancer immunotherapy. In this review, we briefly outlined the applications of macrophages or neutrophils in adoptive cell therapies, and focused on chimeric antigen receptor (CAR)-engineered macrophages (CAR-Ms) and neutrophils (CAR-Ns). We summarized the construction strategies, the preclinical and clinical studies of CAR-Ms and CAR-Ns. In the end, we briefly discussed the limitations and challenges of CAR-Ms and CAR-Ns, as well as future research directions to extend their applications in treating solid tumors. |
| first_indexed | 2024-03-09T14:23:09Z |
| format | Article |
| id | doaj.art-d46a4e4695c149a7bf23f5faa8f4cf97 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-09T14:23:09Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d46a4e4695c149a7bf23f5faa8f4cf972023-11-28T09:59:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-11-011410.3389/fimmu.2023.12916191291619Advancing CAR-based immunotherapies in solid tumors: CAR- macrophages and neutrophilsYanling Liang0Yanling Liang1Qumiao Xu2Qumiao Xu3Qianqian Gao4Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, ChinaHuman Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, ChinaBGI Research, Hangzhou, ChinaBGI Research, Shenzhen, ChinaInstitute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, ChinaMacrophages and neutrophils are the main components of the innate immune system and play important roles in promoting angiogenesis, extracellular matrix remodeling, cancer cell proliferation, and metastasis in the tumor microenvironment (TME). They can also be harnessed to mediate cytotoxic tumor killing effects and orchestrate effective anti-tumor immune responses with proper stimulation and modification. Therefore, macrophages and neutrophils have strong potential in cancer immunotherapy. In this review, we briefly outlined the applications of macrophages or neutrophils in adoptive cell therapies, and focused on chimeric antigen receptor (CAR)-engineered macrophages (CAR-Ms) and neutrophils (CAR-Ns). We summarized the construction strategies, the preclinical and clinical studies of CAR-Ms and CAR-Ns. In the end, we briefly discussed the limitations and challenges of CAR-Ms and CAR-Ns, as well as future research directions to extend their applications in treating solid tumors.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1291619/fullCAR macrophagesCAR neutrophilssolid tumorcancer immunotherapyadoptive cell therapy |
| spellingShingle | Yanling Liang Yanling Liang Qumiao Xu Qumiao Xu Qianqian Gao Advancing CAR-based immunotherapies in solid tumors: CAR- macrophages and neutrophils Frontiers in Immunology CAR macrophages CAR neutrophils solid tumor cancer immunotherapy adoptive cell therapy |
| title | Advancing CAR-based immunotherapies in solid tumors: CAR- macrophages and neutrophils |
| title_full | Advancing CAR-based immunotherapies in solid tumors: CAR- macrophages and neutrophils |
| title_fullStr | Advancing CAR-based immunotherapies in solid tumors: CAR- macrophages and neutrophils |
| title_full_unstemmed | Advancing CAR-based immunotherapies in solid tumors: CAR- macrophages and neutrophils |
| title_short | Advancing CAR-based immunotherapies in solid tumors: CAR- macrophages and neutrophils |
| title_sort | advancing car based immunotherapies in solid tumors car macrophages and neutrophils |
| topic | CAR macrophages CAR neutrophils solid tumor cancer immunotherapy adoptive cell therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1291619/full |
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