World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility
<p>Abstract</p> <p>Intrinsic resistance of <it>Plasmodium falciparum </it>is clearly a major determinant of the clinical failure of antimalarial drugs. However, complex interactions between the host, the parasite and the drug obscure the ability to define parasite drug...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-09-01
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| Series: | Malaria Journal |
| Online Access: | http://www.biomedcentral.com/1475-2875/6/120 |
| _version_ | 1818473685381545984 |
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| author | Ringwald Pascal Fukuda Mark M Wongsrichanalai Chansuda Le Bras Jacques Fandeur Thierry Bacon David J Jambou Ronan Sibley Carol Kyle Dennis E |
| author_facet | Ringwald Pascal Fukuda Mark M Wongsrichanalai Chansuda Le Bras Jacques Fandeur Thierry Bacon David J Jambou Ronan Sibley Carol Kyle Dennis E |
| author_sort | Ringwald Pascal |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Intrinsic resistance of <it>Plasmodium falciparum </it>is clearly a major determinant of the clinical failure of antimalarial drugs. However, complex interactions between the host, the parasite and the drug obscure the ability to define parasite drug resistance in vivo. The in vitro antimalarial drug susceptibility assay determines ex-vivo growth of parasite in the presence of serial drug concentrations and, thus, eliminates host effects, such as drug metabolism and immunity. Although the sensitivity of the parasite to various antimalarials provided by such a test provides an important indicator of intrinsic parasite susceptibility, there are fundamental methodological issues that undermine comparison of in vitro susceptibility both between laboratories and within a single laboratory over time. A network of laboratories is proposed that will agree on the basic parameters of the in vitro test and associated measures of quality control. The aim of the network would be to establish baseline values of sensitivity to commonly used antimalarial agents from key regions of the world, and create a global database, linked to clinical, molecular and pharmacology databases, to support active surveillance to monitor temporal trends in parasite susceptibility. Such a network would facilitate the rapid detection of strains with novel antimalarial resistance profiles and investigate suitable alternative treatments with retained efficacy.</p> |
| first_indexed | 2024-04-14T04:26:43Z |
| format | Article |
| id | doaj.art-d46b442929ea46688580673dd10c6326 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-04-14T04:26:43Z |
| publishDate | 2007-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-d46b442929ea46688580673dd10c63262022-12-22T02:12:17ZengBMCMalaria Journal1475-28752007-09-016112010.1186/1475-2875-6-120World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibilityRingwald PascalFukuda Mark MWongsrichanalai ChansudaLe Bras JacquesFandeur ThierryBacon David JJambou RonanSibley CarolKyle Dennis E<p>Abstract</p> <p>Intrinsic resistance of <it>Plasmodium falciparum </it>is clearly a major determinant of the clinical failure of antimalarial drugs. However, complex interactions between the host, the parasite and the drug obscure the ability to define parasite drug resistance in vivo. The in vitro antimalarial drug susceptibility assay determines ex-vivo growth of parasite in the presence of serial drug concentrations and, thus, eliminates host effects, such as drug metabolism and immunity. Although the sensitivity of the parasite to various antimalarials provided by such a test provides an important indicator of intrinsic parasite susceptibility, there are fundamental methodological issues that undermine comparison of in vitro susceptibility both between laboratories and within a single laboratory over time. A network of laboratories is proposed that will agree on the basic parameters of the in vitro test and associated measures of quality control. The aim of the network would be to establish baseline values of sensitivity to commonly used antimalarial agents from key regions of the world, and create a global database, linked to clinical, molecular and pharmacology databases, to support active surveillance to monitor temporal trends in parasite susceptibility. Such a network would facilitate the rapid detection of strains with novel antimalarial resistance profiles and investigate suitable alternative treatments with retained efficacy.</p>http://www.biomedcentral.com/1475-2875/6/120 |
| spellingShingle | Ringwald Pascal Fukuda Mark M Wongsrichanalai Chansuda Le Bras Jacques Fandeur Thierry Bacon David J Jambou Ronan Sibley Carol Kyle Dennis E World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility Malaria Journal |
| title | World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility |
| title_full | World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility |
| title_fullStr | World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility |
| title_full_unstemmed | World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility |
| title_short | World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility |
| title_sort | world antimalarial resistance network warn ii in vitro antimalarial drug susceptibility |
| url | http://www.biomedcentral.com/1475-2875/6/120 |
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