Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism
Background Parkinsonism as a group of movement disorders, exhibit similar clinical presentation. Therefore, clinically differentiating these diseases is difficult. We investigated the diagnostic value of 99m Tc-TRODAT-1 SPECT in this setting. Due to the fact that this modality has some limitations i...
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| Materiálatiipa: | Artihkal |
| Giella: | English |
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Tabriz University of Medical Sciences Press
2021-11-01
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| Ráidu: | Journal of Research in Clinical Medicine |
| Fáttát: | |
| Liŋkkat: | https://jrcm.tbzmed.ac.ir/PDF/jrcm-9-36.pdf |
| _version_ | 1828955882991386624 |
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| author | Zahra Babaei Aghdam Safa Najmi Tabrizi Amin Arasteh Mohammad Khalafi Morteza Ghojazadeh Babak Mahmoudian |
| author_facet | Zahra Babaei Aghdam Safa Najmi Tabrizi Amin Arasteh Mohammad Khalafi Morteza Ghojazadeh Babak Mahmoudian |
| author_sort | Zahra Babaei Aghdam |
| collection | DOAJ |
| description | Background Parkinsonism as a group of movement disorders, exhibit similar clinical presentation. Therefore, clinically differentiating these diseases is difficult. We investigated the diagnostic value of 99m Tc-TRODAT-1 SPECT in this setting. Due to the fact that this modality has some limitations in imaging small organs like the sub-regions of basal ganglia, we also evaluated the use of anatomical MR imaging along with functional SPECT imaging in parkinsonism. Methods This follow-up diagnostic test evaluation study was performed with 40 patients with the clinical presentation of parkinsonism, and 10 healthy subjects as controls. After administration of the radiopharmaceutical, SPECT images were acquired, then co-registered on MRI. Uptake values were evaluated in basal ganglia semi-quantitatively. Results In this study, 99mTc-TRODAT-1 SPECT was able to differentiate essential tremor and healthy subjects from progressive supranuclear palsy (PSP) and Parkinson’s disease (PD) with a sensitivity of 76.47% and specificity of 100% at a cut-off of 0.53; however, findings were not significant in differentiation of PD from PSP (p >0.05), and the results were similar in SPECT and co-registered MRI/SPECT images. In evaluation of the uptake pattern in basal ganglia, the lateralization of decreased uptake was only seen in PD; and in PSP, the dysfunction was bilateral in all patients. Conclusion 99mTc-TRODAT-1 SPECT is sensitive and specific in diagnosing basal ganglia dysfunction; however, 99mTc-TRODAT-1 SPECT alone or co-registration on MRI are not adequate in differentiation of the etiologies of basal ganglia dysfunction. |
| first_indexed | 2024-12-14T08:00:33Z |
| format | Article |
| id | doaj.art-d46b51a371a445f29bccd0cf9c26361e |
| institution | Directory Open Access Journal |
| issn | 2717-0616 |
| language | English |
| last_indexed | 2024-12-14T08:00:33Z |
| publishDate | 2021-11-01 |
| publisher | Tabriz University of Medical Sciences Press |
| record_format | Article |
| series | Journal of Research in Clinical Medicine |
| spelling | doaj.art-d46b51a371a445f29bccd0cf9c26361e2022-12-21T23:10:25ZengTabriz University of Medical Sciences PressJournal of Research in Clinical Medicine2717-06162021-11-0191363610.34172/jrcm.2021.036jrcm-32026Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in ParkinsonismZahra Babaei Aghdam0Safa Najmi Tabrizi1Amin Arasteh2Mohammad Khalafi3Morteza Ghojazadeh4Babak Mahmoudian5Medical Radiation Sciences Research Team, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Neurology, Tabriz University of Medical Sciences, Tabriz, IranStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, IranStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, IranResearch Center for Evidence-Based Medicine, Iranian EBM Centre: A Joanna Briggs Institute Affiliated Group, Tabriz University of Medical Sciences, Tabriz, IranMedical Radiation Sciences Research Team, Tabriz University of Medical Sciences, Tabriz, IranBackground Parkinsonism as a group of movement disorders, exhibit similar clinical presentation. Therefore, clinically differentiating these diseases is difficult. We investigated the diagnostic value of 99m Tc-TRODAT-1 SPECT in this setting. Due to the fact that this modality has some limitations in imaging small organs like the sub-regions of basal ganglia, we also evaluated the use of anatomical MR imaging along with functional SPECT imaging in parkinsonism. Methods This follow-up diagnostic test evaluation study was performed with 40 patients with the clinical presentation of parkinsonism, and 10 healthy subjects as controls. After administration of the radiopharmaceutical, SPECT images were acquired, then co-registered on MRI. Uptake values were evaluated in basal ganglia semi-quantitatively. Results In this study, 99mTc-TRODAT-1 SPECT was able to differentiate essential tremor and healthy subjects from progressive supranuclear palsy (PSP) and Parkinson’s disease (PD) with a sensitivity of 76.47% and specificity of 100% at a cut-off of 0.53; however, findings were not significant in differentiation of PD from PSP (p >0.05), and the results were similar in SPECT and co-registered MRI/SPECT images. In evaluation of the uptake pattern in basal ganglia, the lateralization of decreased uptake was only seen in PD; and in PSP, the dysfunction was bilateral in all patients. Conclusion 99mTc-TRODAT-1 SPECT is sensitive and specific in diagnosing basal ganglia dysfunction; however, 99mTc-TRODAT-1 SPECT alone or co-registration on MRI are not adequate in differentiation of the etiologies of basal ganglia dysfunction.https://jrcm.tbzmed.ac.ir/PDF/jrcm-9-36.pdfparkinsonian disorderssingle photon emission computed tomography99mtc-trodat-1 |
| spellingShingle | Zahra Babaei Aghdam Safa Najmi Tabrizi Amin Arasteh Mohammad Khalafi Morteza Ghojazadeh Babak Mahmoudian Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism Journal of Research in Clinical Medicine parkinsonian disorders single photon emission computed tomography 99mtc-trodat-1 |
| title | Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism |
| title_full | Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism |
| title_fullStr | Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism |
| title_full_unstemmed | Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism |
| title_short | Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism |
| title_sort | diagnostic evaluation of 99mtc trodat 1 spect in parkinsonism |
| topic | parkinsonian disorders single photon emission computed tomography 99mtc-trodat-1 |
| url | https://jrcm.tbzmed.ac.ir/PDF/jrcm-9-36.pdf |
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