The occurrence and development mechanisms of esophageal stricture: state of the art review
Abstract Background Esophageal strictures significantly impair patient quality of life and present a therapeutic challenge, particularly due to the high recurrence post-ESD/EMR. Current treatments manage symptoms rather than addressing the disease's etiology. This review concentrates on the mec...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-024-04932-2 |
| _version_ | 1827326410374512640 |
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| author | Fang Yang Yiwei Hu Zewen Shi Mujie Liu Kefeng Hu Guoliang Ye Qian Pang Ruixia Hou Keqi Tang Yabin Zhu |
| author_facet | Fang Yang Yiwei Hu Zewen Shi Mujie Liu Kefeng Hu Guoliang Ye Qian Pang Ruixia Hou Keqi Tang Yabin Zhu |
| author_sort | Fang Yang |
| collection | DOAJ |
| description | Abstract Background Esophageal strictures significantly impair patient quality of life and present a therapeutic challenge, particularly due to the high recurrence post-ESD/EMR. Current treatments manage symptoms rather than addressing the disease's etiology. This review concentrates on the mechanisms of esophageal stricture formation and recurrence, seeking to highlight areas for potential therapeutic intervention. Methods A literature search was conducted through PUBMED using search terms: esophageal stricture, mucosal resection, submucosal dissection. Relevant articles were identified through manual review with reference lists reviewed for additional articles. Results Preclinical studies and data from animal studies suggest that the mechanisms that may lead to esophageal stricture include overdifferentiation of fibroblasts, inflammatory response that is not healed in time, impaired epithelial barrier function, and multimethod factors leading to it. Dysfunction of the epithelial barrier may be the initiating mechanism for esophageal stricture. Achieving perfect in-epithelialization by tissue-engineered fabrication of cell patches has been shown to be effective in the treatment and prevention of esophageal strictures. Conclusion The development of esophageal stricture involves three stages: structural damage to the esophageal epithelial barrier (EEB), chronic inflammation, and severe fibrosis, in which dysfunction or damage to the EEB is the initiating mechanism leading to esophageal stricture. Re-epithelialization is essential for the treatment and prevention of esophageal stricture. This information will help clinicians or scientists to develop effective techniques to treat esophageal stricture in the future. |
| first_indexed | 2024-03-07T14:44:04Z |
| format | Article |
| id | doaj.art-d46c180ef8e64c8dbc303f914cb899b2 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-03-07T14:44:04Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-d46c180ef8e64c8dbc303f914cb899b22024-03-05T20:06:24ZengBMCJournal of Translational Medicine1479-58762024-01-0122111410.1186/s12967-024-04932-2The occurrence and development mechanisms of esophageal stricture: state of the art reviewFang Yang0Yiwei Hu1Zewen Shi2Mujie Liu3Kefeng Hu4Guoliang Ye5Qian Pang6Ruixia Hou7Keqi Tang8Yabin Zhu9Health Science Center, Ningbo UniversityHealth Science Center, Ningbo UniversityHealth Science Center, Ningbo UniversityHealth Science Center, Ningbo UniversityThe First Affiliated Hospital of Ningbo UniversityThe First Affiliated Hospital of Ningbo UniversityHealth Science Center, Ningbo UniversityHealth Science Center, Ningbo UniversityInstitute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo UniversityHealth Science Center, Ningbo UniversityAbstract Background Esophageal strictures significantly impair patient quality of life and present a therapeutic challenge, particularly due to the high recurrence post-ESD/EMR. Current treatments manage symptoms rather than addressing the disease's etiology. This review concentrates on the mechanisms of esophageal stricture formation and recurrence, seeking to highlight areas for potential therapeutic intervention. Methods A literature search was conducted through PUBMED using search terms: esophageal stricture, mucosal resection, submucosal dissection. Relevant articles were identified through manual review with reference lists reviewed for additional articles. Results Preclinical studies and data from animal studies suggest that the mechanisms that may lead to esophageal stricture include overdifferentiation of fibroblasts, inflammatory response that is not healed in time, impaired epithelial barrier function, and multimethod factors leading to it. Dysfunction of the epithelial barrier may be the initiating mechanism for esophageal stricture. Achieving perfect in-epithelialization by tissue-engineered fabrication of cell patches has been shown to be effective in the treatment and prevention of esophageal strictures. Conclusion The development of esophageal stricture involves three stages: structural damage to the esophageal epithelial barrier (EEB), chronic inflammation, and severe fibrosis, in which dysfunction or damage to the EEB is the initiating mechanism leading to esophageal stricture. Re-epithelialization is essential for the treatment and prevention of esophageal stricture. This information will help clinicians or scientists to develop effective techniques to treat esophageal stricture in the future.https://doi.org/10.1186/s12967-024-04932-2EsophagusStrictureBiological mechanismOccurrenceDevelopment |
| spellingShingle | Fang Yang Yiwei Hu Zewen Shi Mujie Liu Kefeng Hu Guoliang Ye Qian Pang Ruixia Hou Keqi Tang Yabin Zhu The occurrence and development mechanisms of esophageal stricture: state of the art review Journal of Translational Medicine Esophagus Stricture Biological mechanism Occurrence Development |
| title | The occurrence and development mechanisms of esophageal stricture: state of the art review |
| title_full | The occurrence and development mechanisms of esophageal stricture: state of the art review |
| title_fullStr | The occurrence and development mechanisms of esophageal stricture: state of the art review |
| title_full_unstemmed | The occurrence and development mechanisms of esophageal stricture: state of the art review |
| title_short | The occurrence and development mechanisms of esophageal stricture: state of the art review |
| title_sort | occurrence and development mechanisms of esophageal stricture state of the art review |
| topic | Esophagus Stricture Biological mechanism Occurrence Development |
| url | https://doi.org/10.1186/s12967-024-04932-2 |
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