Comparison of drug-eluting balloon versus drug-eluting stent for treatment of coronary artery disease: a meta-analysis of randomized controlled trials
Abstract Background Drug-eluting balloons (DEB) have significant value for treating coronary artery disease (CAD). However, the merits of using DEB versus drug-eluting stents (DES) to treat CAD remain controversial. Herein, we conducted a meta-analysis to compare the safety and efficacy of DEB and D...
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| Format: | Article |
| Language: | English |
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BMC
2018-03-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12872-018-0771-y |
| _version_ | 1818301691994308608 |
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| author | Lulu Liu Bin Liu Jiajun Ren Gang Hui Chao Qi Junnan Wang |
| author_facet | Lulu Liu Bin Liu Jiajun Ren Gang Hui Chao Qi Junnan Wang |
| author_sort | Lulu Liu |
| collection | DOAJ |
| description | Abstract Background Drug-eluting balloons (DEB) have significant value for treating coronary artery disease (CAD). However, the merits of using DEB versus drug-eluting stents (DES) to treat CAD remain controversial. Herein, we conducted a meta-analysis to compare the safety and efficacy of DEB and DES for treatment of CAD. Methods We searched MEDLINE, EMBASE, and CENTRAL databases for eligible trials comparing DEB with DES for treatment of CAD. The primary endpoint was major adverse cardiac events (MACE); the secondary endpoints included in-lesion late lumen loss (LLL), binary restenosis (BR), myocardial infarction (MI), target lesion revascularization (TLR) and mortality. Results Twenty-three trials with a total of 2712 patients were included. There were no significant differences in the primary endpoint of MACE between the DEB and DES groups (Risk Ratio (RR) 1.19; 95% confidence interval (CI) (0.87, 1.63); P = 0.27), or in the clinical outcomes of each of MACE’s components, including TLR, MI and mortality. However, efficacy was significantly different between the DEB and DES groups, especially when we compared DEB to second-generation DES: in-lesion LLL (Mean Difference (MD) 0.11; (0.01, 0.22); P = 0.03); binary restenosis (RR 1.46; (1.00, 2.13); P = 0.05). Conclusions DEB is equivalent to DES in terms of safety for managing CAD, and DEB may be considered as an alternative choice for treatment of CAD. |
| first_indexed | 2024-12-13T05:27:03Z |
| format | Article |
| id | doaj.art-d46c958ff70f4e60a5f7b6398a331c53 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-13T05:27:03Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-d46c958ff70f4e60a5f7b6398a331c532022-12-21T23:58:09ZengBMCBMC Cardiovascular Disorders1471-22612018-03-0118111610.1186/s12872-018-0771-yComparison of drug-eluting balloon versus drug-eluting stent for treatment of coronary artery disease: a meta-analysis of randomized controlled trialsLulu Liu0Bin Liu1Jiajun Ren2Gang Hui3Chao Qi4Junnan Wang5Department of Cardiology, Second Hospital of Jilin UniversityDepartment of Cardiology, Second Hospital of Jilin UniversityDepartment of Cardiology, Second Hospital of Jilin UniversityDepartment of Cardiology, Second Hospital of Jilin UniversityDepartment of Cardiology, Second Hospital of Jilin UniversityDepartment of Cardiology, Second Hospital of Jilin UniversityAbstract Background Drug-eluting balloons (DEB) have significant value for treating coronary artery disease (CAD). However, the merits of using DEB versus drug-eluting stents (DES) to treat CAD remain controversial. Herein, we conducted a meta-analysis to compare the safety and efficacy of DEB and DES for treatment of CAD. Methods We searched MEDLINE, EMBASE, and CENTRAL databases for eligible trials comparing DEB with DES for treatment of CAD. The primary endpoint was major adverse cardiac events (MACE); the secondary endpoints included in-lesion late lumen loss (LLL), binary restenosis (BR), myocardial infarction (MI), target lesion revascularization (TLR) and mortality. Results Twenty-three trials with a total of 2712 patients were included. There were no significant differences in the primary endpoint of MACE between the DEB and DES groups (Risk Ratio (RR) 1.19; 95% confidence interval (CI) (0.87, 1.63); P = 0.27), or in the clinical outcomes of each of MACE’s components, including TLR, MI and mortality. However, efficacy was significantly different between the DEB and DES groups, especially when we compared DEB to second-generation DES: in-lesion LLL (Mean Difference (MD) 0.11; (0.01, 0.22); P = 0.03); binary restenosis (RR 1.46; (1.00, 2.13); P = 0.05). Conclusions DEB is equivalent to DES in terms of safety for managing CAD, and DEB may be considered as an alternative choice for treatment of CAD.http://link.springer.com/article/10.1186/s12872-018-0771-yCoronary artery diseaseDrug-eluting balloonDrug-eluting stentMeta-analysis |
| spellingShingle | Lulu Liu Bin Liu Jiajun Ren Gang Hui Chao Qi Junnan Wang Comparison of drug-eluting balloon versus drug-eluting stent for treatment of coronary artery disease: a meta-analysis of randomized controlled trials BMC Cardiovascular Disorders Coronary artery disease Drug-eluting balloon Drug-eluting stent Meta-analysis |
| title | Comparison of drug-eluting balloon versus drug-eluting stent for treatment of coronary artery disease: a meta-analysis of randomized controlled trials |
| title_full | Comparison of drug-eluting balloon versus drug-eluting stent for treatment of coronary artery disease: a meta-analysis of randomized controlled trials |
| title_fullStr | Comparison of drug-eluting balloon versus drug-eluting stent for treatment of coronary artery disease: a meta-analysis of randomized controlled trials |
| title_full_unstemmed | Comparison of drug-eluting balloon versus drug-eluting stent for treatment of coronary artery disease: a meta-analysis of randomized controlled trials |
| title_short | Comparison of drug-eluting balloon versus drug-eluting stent for treatment of coronary artery disease: a meta-analysis of randomized controlled trials |
| title_sort | comparison of drug eluting balloon versus drug eluting stent for treatment of coronary artery disease a meta analysis of randomized controlled trials |
| topic | Coronary artery disease Drug-eluting balloon Drug-eluting stent Meta-analysis |
| url | http://link.springer.com/article/10.1186/s12872-018-0771-y |
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