Early Renoprotective Effect of Ruxolitinib in a Rat Model of Diabetic Nephropathy

Early Renoprotective Effect of Ruxolitinib in a Rat Model of Diabetic Nephropathy

Diabetic kidney disease (DKD) is still one of the unresolved major complications of diabetes mellitus, which leads ultimately to end-stage renal disease in both type 1 and type 2 diabetes patients. Available drugs that suppress the renin–angiotensin system have partially minimized the disease impact...

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Bibliographic Details
Main Authors: Mohamed M. El-Kady, Reham A. Naggar, Maha Guimei, Iman M. Talaat, Olfat G. Shaker, Maha Saber-Ayad
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceuticals
Subjects:
diabetic nephropathy
ruxolitinib
JAK inhibitors
glomerulosclerosis
tubulointerstitial fibrosis
rat model
Online Access:https://www.mdpi.com/1424-8247/14/7/608

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