Nephron-sparing surgery in bilateral Wilms' tumor: A report of two cases
Nephron-sparing surgery (NSS) has been proposed by many as an alternative to bilateral nephrectomies and renal replacement therapy in bilateral Wilms' tumor (BWT). NSS is not without significant recurrence, morbidity, and mortality. Long-term follow-up, especially with regard to the renal funct...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Urology Annals |
| Subjects: | |
| Online Access: | http://www.urologyannals.com/article.asp?issn=0974-7796;year=2016;volume=8;issue=4;spage=486;epage=489;aulast=Arora |
| _version_ | 1811302708420804608 |
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| author | Sohrab Arora Sharmad Kudchadkar Priyank Yadav M S Ansari |
| author_facet | Sohrab Arora Sharmad Kudchadkar Priyank Yadav M S Ansari |
| author_sort | Sohrab Arora |
| collection | DOAJ |
| description | Nephron-sparing surgery (NSS) has been proposed by many as an alternative to bilateral nephrectomies and renal replacement therapy in bilateral Wilms' tumor (BWT). NSS is not without significant recurrence, morbidity, and mortality. Long-term follow-up, especially with regard to the renal function, remains lacking. Preoperative computed tomography angiogram can help prepare a roadmap for NSS but can underestimate the salvageable parenchyma due to compression of normal adjacent parenchyma. Intraoperative ultrasound can delineate the boundary of surgical margin and help achieve negative margins. We present two cases of BWT, aged 7 and 13 months, managed with neoadjuvant chemotherapy followed by bilateral NSS and adjuvant chemotherapy and report the follow-up of the same. We also explore the role of preoperative imaging and intraoperative ultrasound in the management. Both patients are alive without recurrence at a follow-up of 12 and 8 months. |
| first_indexed | 2024-04-13T07:34:01Z |
| format | Article |
| id | doaj.art-d46d4255e7cf4caf8165d85e6d724cf4 |
| institution | Directory Open Access Journal |
| issn | 0974-7796 0974-7834 |
| language | English |
| last_indexed | 2024-04-13T07:34:01Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Urology Annals |
| spelling | doaj.art-d46d4255e7cf4caf8165d85e6d724cf42022-12-22T02:56:16ZengWolters Kluwer Medknow PublicationsUrology Annals0974-77960974-78342016-01-018448648910.4103/0974-7796.192102Nephron-sparing surgery in bilateral Wilms' tumor: A report of two casesSohrab AroraSharmad KudchadkarPriyank YadavM S AnsariNephron-sparing surgery (NSS) has been proposed by many as an alternative to bilateral nephrectomies and renal replacement therapy in bilateral Wilms' tumor (BWT). NSS is not without significant recurrence, morbidity, and mortality. Long-term follow-up, especially with regard to the renal function, remains lacking. Preoperative computed tomography angiogram can help prepare a roadmap for NSS but can underestimate the salvageable parenchyma due to compression of normal adjacent parenchyma. Intraoperative ultrasound can delineate the boundary of surgical margin and help achieve negative margins. We present two cases of BWT, aged 7 and 13 months, managed with neoadjuvant chemotherapy followed by bilateral NSS and adjuvant chemotherapy and report the follow-up of the same. We also explore the role of preoperative imaging and intraoperative ultrasound in the management. Both patients are alive without recurrence at a follow-up of 12 and 8 months.http://www.urologyannals.com/article.asp?issn=0974-7796;year=2016;volume=8;issue=4;spage=486;epage=489;aulast=AroraNeoadjuvant chemotherapynephron-sparing surgeryWilms' tumor |
| spellingShingle | Sohrab Arora Sharmad Kudchadkar Priyank Yadav M S Ansari Nephron-sparing surgery in bilateral Wilms' tumor: A report of two cases Urology Annals Neoadjuvant chemotherapy nephron-sparing surgery Wilms' tumor |
| title | Nephron-sparing surgery in bilateral Wilms' tumor: A report of two cases |
| title_full | Nephron-sparing surgery in bilateral Wilms' tumor: A report of two cases |
| title_fullStr | Nephron-sparing surgery in bilateral Wilms' tumor: A report of two cases |
| title_full_unstemmed | Nephron-sparing surgery in bilateral Wilms' tumor: A report of two cases |
| title_short | Nephron-sparing surgery in bilateral Wilms' tumor: A report of two cases |
| title_sort | nephron sparing surgery in bilateral wilms tumor a report of two cases |
| topic | Neoadjuvant chemotherapy nephron-sparing surgery Wilms' tumor |
| url | http://www.urologyannals.com/article.asp?issn=0974-7796;year=2016;volume=8;issue=4;spage=486;epage=489;aulast=Arora |
| work_keys_str_mv | AT sohrabarora nephronsparingsurgeryinbilateralwilmstumorareportoftwocases AT sharmadkudchadkar nephronsparingsurgeryinbilateralwilmstumorareportoftwocases AT priyankyadav nephronsparingsurgeryinbilateralwilmstumorareportoftwocases AT msansari nephronsparingsurgeryinbilateralwilmstumorareportoftwocases |