APPLICATION OF TINCNURE FROM LEMNA MINOR FROND, L-THYROXIN AND THEIR COMBINATION FOR THE CORRECTION OF THE HYPOTYROID STATE IN RATS
To treat hypothyroid conditions mainly use hormone replacement therapy, which causes side effects and often leads to hormone-resistance. However, there was a need to find alternative methods for compensation of hypothyroid state, one of which is herbal preparations. The aim. Study of the efficiency...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Ukrainian Medical Stomatological Academy
2019-04-01
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| Series: | Вісник проблем біології і медицини |
| Subjects: | |
| Online Access: | https://vpbm.com.ua/upload/2019-2-1/33-min.pdf |
| _version_ | 1811249281035665408 |
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| author | Kononenko A. G. Kravchenko V. M. |
| author_facet | Kononenko A. G. Kravchenko V. M. |
| author_sort | Kononenko A. G. |
| collection | DOAJ |
| description | To treat hypothyroid conditions mainly use hormone replacement therapy, which causes side effects
and often leads to hormone-resistance. However, there was a need to find alternative methods for compensation of
hypothyroid state, one of which is herbal preparations.
The aim. Study of the efficiency of 30% tincture from Lemna minor frond and its combination with L-thyroxin in
experimental hypothyroidism.
Object and methods. Experimental hypothyroidism induced by daily administration of mercazolilum solution instead of drinking water for 30 days. Hypothyroid animals received orally tincture from Lemna minor frond, L-thyroxin
and its combination. After experiment blood collected, thyroid gland isolated and weighed in rats. Concentrations of
T3
, fT3
, fT4
and T4
estimated in blood serum samples.
Results. It established that the weight of the thyroid gland in rats treated with tincture from Lemna minor frond
decreased in 2.6 times (p <0.05), in rats treated with L-thyroxin decreased in 1.9 times (p <0.05). Combination
of tincture from Lemna minor frond with L-thyroxin led to a decreasing of thyroid weight in 2.5 times (p <0.05)
compared with a CP group. Introduction of tincture from Lemna minor frond contributed to significant increase of
T4
, fT4
, fT3
and T3
in 2.4, 2.7, 1.6 and 1.9 times (p <0.05), respectively, compared with a CP group. Administration of
L-thyroxin led to the likely increase of T4
, fT4
, fT3
and T3
compared to the CP group in 1.9, 1.9, 1.50 and 1.9 times (p
<0.05), respectively. Combination of investigated objects increased levels of T4
, fT4
, fT3
and T3
in 2.4, 3.1, 1.8 and 1.9
times compared to the animals of CP group.
Conclusions. The administration of tincture from Lemna minor frond and L-thyroxin benefit a corrective effect on
the thyroid gland hypofunction, and introduction of their combination led to their effect potentiation. |
| first_indexed | 2024-04-12T15:43:41Z |
| format | Article |
| id | doaj.art-d46fa437c6d24de890fc50e46084a826 |
| institution | Directory Open Access Journal |
| issn | 2077-4214 2523-4110 |
| language | English |
| last_indexed | 2024-04-12T15:43:41Z |
| publishDate | 2019-04-01 |
| publisher | Ukrainian Medical Stomatological Academy |
| record_format | Article |
| series | Вісник проблем біології і медицини |
| spelling | doaj.art-d46fa437c6d24de890fc50e46084a8262022-12-22T03:26:43ZengUkrainian Medical Stomatological AcademyВісник проблем біології і медицини2077-42142523-41102019-04-012115215510.29254/2077-4214-2019-1-2-149-152-1552077-4214-2019-1-2-149-152-155APPLICATION OF TINCNURE FROM LEMNA MINOR FROND, L-THYROXIN AND THEIR COMBINATION FOR THE CORRECTION OF THE HYPOTYROID STATE IN RATSKononenko A. G.0Kravchenko V. M.1 University Name University Name To treat hypothyroid conditions mainly use hormone replacement therapy, which causes side effects and often leads to hormone-resistance. However, there was a need to find alternative methods for compensation of hypothyroid state, one of which is herbal preparations. The aim. Study of the efficiency of 30% tincture from Lemna minor frond and its combination with L-thyroxin in experimental hypothyroidism. Object and methods. Experimental hypothyroidism induced by daily administration of mercazolilum solution instead of drinking water for 30 days. Hypothyroid animals received orally tincture from Lemna minor frond, L-thyroxin and its combination. After experiment blood collected, thyroid gland isolated and weighed in rats. Concentrations of T3 , fT3 , fT4 and T4 estimated in blood serum samples. Results. It established that the weight of the thyroid gland in rats treated with tincture from Lemna minor frond decreased in 2.6 times (p <0.05), in rats treated with L-thyroxin decreased in 1.9 times (p <0.05). Combination of tincture from Lemna minor frond with L-thyroxin led to a decreasing of thyroid weight in 2.5 times (p <0.05) compared with a CP group. Introduction of tincture from Lemna minor frond contributed to significant increase of T4 , fT4 , fT3 and T3 in 2.4, 2.7, 1.6 and 1.9 times (p <0.05), respectively, compared with a CP group. Administration of L-thyroxin led to the likely increase of T4 , fT4 , fT3 and T3 compared to the CP group in 1.9, 1.9, 1.50 and 1.9 times (p <0.05), respectively. Combination of investigated objects increased levels of T4 , fT4 , fT3 and T3 in 2.4, 3.1, 1.8 and 1.9 times compared to the animals of CP group. Conclusions. The administration of tincture from Lemna minor frond and L-thyroxin benefit a corrective effect on the thyroid gland hypofunction, and introduction of their combination led to their effect potentiation. https://vpbm.com.ua/upload/2019-2-1/33-min.pdf tincture from Lemna minor frondexperimental hypothyroidismmercazolilumthyroid hormonesL-thyroxin. |
| spellingShingle | Kononenko A. G. Kravchenko V. M. APPLICATION OF TINCNURE FROM LEMNA MINOR FROND, L-THYROXIN AND THEIR COMBINATION FOR THE CORRECTION OF THE HYPOTYROID STATE IN RATS Вісник проблем біології і медицини tincture from Lemna minor frond experimental hypothyroidism mercazolilum thyroid hormones L-thyroxin. |
| title | APPLICATION OF TINCNURE FROM LEMNA MINOR FROND, L-THYROXIN AND THEIR COMBINATION FOR THE CORRECTION OF THE HYPOTYROID STATE IN RATS |
| title_full | APPLICATION OF TINCNURE FROM LEMNA MINOR FROND, L-THYROXIN AND THEIR COMBINATION FOR THE CORRECTION OF THE HYPOTYROID STATE IN RATS |
| title_fullStr | APPLICATION OF TINCNURE FROM LEMNA MINOR FROND, L-THYROXIN AND THEIR COMBINATION FOR THE CORRECTION OF THE HYPOTYROID STATE IN RATS |
| title_full_unstemmed | APPLICATION OF TINCNURE FROM LEMNA MINOR FROND, L-THYROXIN AND THEIR COMBINATION FOR THE CORRECTION OF THE HYPOTYROID STATE IN RATS |
| title_short | APPLICATION OF TINCNURE FROM LEMNA MINOR FROND, L-THYROXIN AND THEIR COMBINATION FOR THE CORRECTION OF THE HYPOTYROID STATE IN RATS |
| title_sort | application of tincnure from lemna minor frond l thyroxin and their combination for the correction of the hypotyroid state in rats |
| topic | tincture from Lemna minor frond experimental hypothyroidism mercazolilum thyroid hormones L-thyroxin. |
| url | https://vpbm.com.ua/upload/2019-2-1/33-min.pdf |
| work_keys_str_mv | AT kononenkoag applicationoftincnurefromlemnaminorfrondlthyroxinandtheircombinationforthecorrectionofthehypotyroidstateinrats AT kravchenkovm applicationoftincnurefromlemnaminorfrondlthyroxinandtheircombinationforthecorrectionofthehypotyroidstateinrats |