Reversible contrast enhancement for visualization of human temporal bones using micro computed tomography
Sensorineural hearing loss (SNHL), which typically arises from the inner ear, is the most common sensory deficit worldwide. The traditional method for studying pathophysiology underlying human SNHL involves histological processing of the inner ear from temporal bones collected during autopsy. Histop...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.952348/full |
| _version_ | 1811238475778752512 |
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| author | Krishna K. Bommakanti Krishna K. Bommakanti Janani S. Iyer Janani S. Iyer Janani S. Iyer Varun Sagi Varun Sagi Alyssa Brown Xiaojie Ma Xiaojie Ma Marissa Gonzales Konstantina M. Stankovic Konstantina M. Stankovic Konstantina M. Stankovic |
| author_facet | Krishna K. Bommakanti Krishna K. Bommakanti Janani S. Iyer Janani S. Iyer Janani S. Iyer Varun Sagi Varun Sagi Alyssa Brown Xiaojie Ma Xiaojie Ma Marissa Gonzales Konstantina M. Stankovic Konstantina M. Stankovic Konstantina M. Stankovic |
| author_sort | Krishna K. Bommakanti |
| collection | DOAJ |
| description | Sensorineural hearing loss (SNHL), which typically arises from the inner ear, is the most common sensory deficit worldwide. The traditional method for studying pathophysiology underlying human SNHL involves histological processing of the inner ear from temporal bones collected during autopsy. Histopathological analysis is destructive and limits future use of a given specimen. Non-destructive strategies for the study of the inner ear are urgently needed to fully leverage the utility of each specimen because access to human temporal bones is increasingly difficult and these precious specimens are required to uncover disease mechanisms and to enable development of new devices. We highlight the potential of reversible iodine staining for micro-computed tomography imaging of the human inner ear. This approach provides reversible, high-resolution visualization of intracochlear structures and is becoming more rapid and accessible. |
| first_indexed | 2024-04-12T12:43:17Z |
| format | Article |
| id | doaj.art-d470f48e6192472694b2c7dc524d8b5c |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-12T12:43:17Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-d470f48e6192472694b2c7dc524d8b5c2022-12-22T03:32:44ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-10-01910.3389/fsurg.2022.952348952348Reversible contrast enhancement for visualization of human temporal bones using micro computed tomographyKrishna K. Bommakanti0Krishna K. Bommakanti1Janani S. Iyer2Janani S. Iyer3Janani S. Iyer4Varun Sagi5Varun Sagi6Alyssa Brown7Xiaojie Ma8Xiaojie Ma9Marissa Gonzales10Konstantina M. Stankovic11Konstantina M. Stankovic12Konstantina M. Stankovic13Department of Head / Neck Surgery, University of California Los Angeles, Los Angeles, CA, United StatesDepartment of Otolaryngology – Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, United StatesDepartment of Otolaryngology – Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, United StatesDepartment of Otolaryngology, Harvard Medical School, Boston, MA, United StatesProgram in Speech and Hearing Bioscience and Technology, Harvard University Graduate School of Arts and Sciences, Cambridge, MA, United StatesDepartment of Otolaryngology – Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, United StatesUniversity of Minnesota Medical School, Minneapolis, MN, United StatesDepartment of Otolaryngology – Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, United StatesDepartment of Otolaryngology – Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, United StatesDepartment of Otolaryngology, Harvard Medical School, Boston, MA, United StatesDepartment of Otolaryngology – Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, United StatesDepartment of Otolaryngology – Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, United StatesDepartment of Otolaryngology, Harvard Medical School, Boston, MA, United StatesDepartment of Otolaryngology – Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, United StatesSensorineural hearing loss (SNHL), which typically arises from the inner ear, is the most common sensory deficit worldwide. The traditional method for studying pathophysiology underlying human SNHL involves histological processing of the inner ear from temporal bones collected during autopsy. Histopathological analysis is destructive and limits future use of a given specimen. Non-destructive strategies for the study of the inner ear are urgently needed to fully leverage the utility of each specimen because access to human temporal bones is increasingly difficult and these precious specimens are required to uncover disease mechanisms and to enable development of new devices. We highlight the potential of reversible iodine staining for micro-computed tomography imaging of the human inner ear. This approach provides reversible, high-resolution visualization of intracochlear structures and is becoming more rapid and accessible.https://www.frontiersin.org/articles/10.3389/fsurg.2022.952348/fullmicro-computed tomographyiodine stainingreversibletemporal bonehearing loss |
| spellingShingle | Krishna K. Bommakanti Krishna K. Bommakanti Janani S. Iyer Janani S. Iyer Janani S. Iyer Varun Sagi Varun Sagi Alyssa Brown Xiaojie Ma Xiaojie Ma Marissa Gonzales Konstantina M. Stankovic Konstantina M. Stankovic Konstantina M. Stankovic Reversible contrast enhancement for visualization of human temporal bones using micro computed tomography Frontiers in Surgery micro-computed tomography iodine staining reversible temporal bone hearing loss |
| title | Reversible contrast enhancement for visualization of human temporal bones using micro computed tomography |
| title_full | Reversible contrast enhancement for visualization of human temporal bones using micro computed tomography |
| title_fullStr | Reversible contrast enhancement for visualization of human temporal bones using micro computed tomography |
| title_full_unstemmed | Reversible contrast enhancement for visualization of human temporal bones using micro computed tomography |
| title_short | Reversible contrast enhancement for visualization of human temporal bones using micro computed tomography |
| title_sort | reversible contrast enhancement for visualization of human temporal bones using micro computed tomography |
| topic | micro-computed tomography iodine staining reversible temporal bone hearing loss |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.952348/full |
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