Heparanase Increases Podocyte Survival and Autophagic Flux after Adriamycin-Induced Injury

Heparanase Increases Podocyte Survival and Autophagic Flux after Adriamycin-Induced Injury

The kidney glomerular filtration barrier (GFB) is enriched with heparan sulfate (HS) proteoglycans, which contribute to its permselectivity. The endoglycosidase heparanase cleaves HS and hence appears to be involved in the pathogenesis of kidney injury and glomerulonephritis. We have recently report...

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Bibliographic Details
Main Authors: Hanan Abu-Tayeh Suleiman, Shereen Said, Haya Ali Saleh, Aviva Gamliel-Lazarovich, Eyas Haddad, Irina Minkov, Yaniv Zohar, Neta Ilan, Israel Vlodavsky, Zaid Abassi, Suheir Assady
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
heparanase
Adriamycin nephropathy
autophagy
podocytes
cell viability
glomerular filtration barrier
Online Access:https://www.mdpi.com/1422-0067/23/20/12691

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