Retroposed copies of RET gene: a somatically acquired event in medullary thyroid carcinoma

Retroposed copies of RET gene: a somatically acquired event in medullary thyroid carcinoma

Abstract Background Different pathogenic germline mutations in the RET oncogene are identified in MEN 2, a hereditary syndrome characterized by medullary thyroid carcinoma (MTC) and other endocrine tumors. Although genetic predisposition is recognized, not all RET mutation carriers will develop the...

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Bibliographic Details
Main Authors: Larissa V. Bim, Fábio C. P. Navarro, Flávia O. F. Valente, José V. Lima-Junior, Rosana Delcelo, Magnus R. Dias-da-Silva, Rui M. B. Maciel, Pedro A. F. Galante, Janete M. Cerutti
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Medical Genomics
Subjects:
RET
Retrocopy
Second hit
Medullary thyroid carcinoma
MTC
G548V
Online Access:http://link.springer.com/article/10.1186/s12920-019-0552-1

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