Rapid Generation of Murine Bispecific Antibodies Using FAST-Ig<sup>TM</sup> for Preclinical Screening of HER2/CD3 T-Cell Engagers

Rapid Generation of Murine Bispecific Antibodies Using FAST-Ig<sup>TM</sup> for Preclinical Screening of HER2/CD3 T-Cell Engagers

Bispecific antibodies (BsAbs) can bind to two different antigens, enabling therapeutic concepts that cannot be achieved with monoclonal antibodies. Immuno-competent mice are essential for validating drug discovery concepts, necessitating the development of surrogate mouse BsAbs. In this study, we ex...

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Bibliographic Details
Main Authors: Hikaru Koga, Haruka Kuroi, Rena Hirano, Hiroyuki Hirayama, Yoshiaki Nabuchi, Taichi Kuramochi
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Antibodies
Subjects:
bispecific antibody
FAST-Ig
surrogate mouse bispecific antibody
orthogonal Fab
single-cell production
Online Access:https://www.mdpi.com/2073-4468/13/1/3

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