Unveiling the Role of Contingent Negative Variation (CNV) in Migraine: A Review of Electrophysiological Studies in Adults and Children
Migraine has been considered a chronic neuronal-based pain disorder characterized by the presence of cortical hyperexcitability. The Contingent Negative Variation (CNV) is the most explored electrophysiological index in migraine. However, the findings show inconsistencies regarding its functional si...
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MDPI AG
2023-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/11/3030 |
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| author | María E. de Lahoz Paloma Barjola Irene Peláez David Ferrera Roberto Fernandes-Magalhaes Francisco Mercado |
| author_facet | María E. de Lahoz Paloma Barjola Irene Peláez David Ferrera Roberto Fernandes-Magalhaes Francisco Mercado |
| author_sort | María E. de Lahoz |
| collection | DOAJ |
| description | Migraine has been considered a chronic neuronal-based pain disorder characterized by the presence of cortical hyperexcitability. The Contingent Negative Variation (CNV) is the most explored electrophysiological index in migraine. However, the findings show inconsistencies regarding its functional significance. To address this, we conducted a review in both adults and children with migraine without aura to gain a deeper understanding of it and to derive clinical implications. The literature search was conducted in the PubMed, SCOPUS and PsycINFO databases until September 2022m and 34 articles were retrieved and considered relevant for further analysis. The main results in adults showed higher CNV amplitudes (with no habituation) in migraine patients. Electrophysiological abnormalities, particularly focused on the early CNV subcomponent (eCNV), were especially prominent a few days before the onset of a migraine attack, normalizing during and after the attack. We also explored various modulatory factors, including pharmacological treatments—CNV amplitude was lower after the intake of drugs targeting neural hyperexcitability—and other factors such as psychological, hormonal or genetic/familial influences on CNV. Although similar patterns were found in children, the evidence is particularly scarce and less consistent, likely due to the brain’s maturation process during childhood. As the first review exploring the relationship between CNV and migraine, this study supports the role of the CNV as a potential neural marker for migraine pathophysiology and the prediction of pain attacks. The importance of further exploring the relationship between this neurophysiological index and childhood migraine is critical for identifying potential therapeutic targets for managing migraine symptoms during its development. |
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| language | English |
| last_indexed | 2024-03-09T16:59:46Z |
| publishDate | 2023-11-01 |
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| series | Biomedicines |
| spelling | doaj.art-d47445770a174aa4b0c09c9c93b0253e2023-11-24T14:31:14ZengMDPI AGBiomedicines2227-90592023-11-011111303010.3390/biomedicines11113030Unveiling the Role of Contingent Negative Variation (CNV) in Migraine: A Review of Electrophysiological Studies in Adults and ChildrenMaría E. de Lahoz0Paloma Barjola1Irene Peláez2David Ferrera3Roberto Fernandes-Magalhaes4Francisco Mercado5Department of Psychology, School of Health Sciences, Universidad Rey Juan Carlos, 28922 Madrid, SpainDepartment of Psychology, School of Health Sciences, Universidad Rey Juan Carlos, 28922 Madrid, SpainDepartment of Psychology, School of Health Sciences, Universidad Rey Juan Carlos, 28922 Madrid, SpainDepartment of Psychology, School of Health Sciences, Universidad Rey Juan Carlos, 28922 Madrid, SpainDepartment of Psychology, School of Health Sciences, Universidad Rey Juan Carlos, 28922 Madrid, SpainDepartment of Psychology, School of Health Sciences, Universidad Rey Juan Carlos, 28922 Madrid, SpainMigraine has been considered a chronic neuronal-based pain disorder characterized by the presence of cortical hyperexcitability. The Contingent Negative Variation (CNV) is the most explored electrophysiological index in migraine. However, the findings show inconsistencies regarding its functional significance. To address this, we conducted a review in both adults and children with migraine without aura to gain a deeper understanding of it and to derive clinical implications. The literature search was conducted in the PubMed, SCOPUS and PsycINFO databases until September 2022m and 34 articles were retrieved and considered relevant for further analysis. The main results in adults showed higher CNV amplitudes (with no habituation) in migraine patients. Electrophysiological abnormalities, particularly focused on the early CNV subcomponent (eCNV), were especially prominent a few days before the onset of a migraine attack, normalizing during and after the attack. We also explored various modulatory factors, including pharmacological treatments—CNV amplitude was lower after the intake of drugs targeting neural hyperexcitability—and other factors such as psychological, hormonal or genetic/familial influences on CNV. Although similar patterns were found in children, the evidence is particularly scarce and less consistent, likely due to the brain’s maturation process during childhood. As the first review exploring the relationship between CNV and migraine, this study supports the role of the CNV as a potential neural marker for migraine pathophysiology and the prediction of pain attacks. The importance of further exploring the relationship between this neurophysiological index and childhood migraine is critical for identifying potential therapeutic targets for managing migraine symptoms during its development.https://www.mdpi.com/2227-9059/11/11/3030Contingent Negative Variation (CNV)migraine without auramigraine cyclechildrencortical hyperexcitabilityS1–S2 paradigm |
| spellingShingle | María E. de Lahoz Paloma Barjola Irene Peláez David Ferrera Roberto Fernandes-Magalhaes Francisco Mercado Unveiling the Role of Contingent Negative Variation (CNV) in Migraine: A Review of Electrophysiological Studies in Adults and Children Biomedicines Contingent Negative Variation (CNV) migraine without aura migraine cycle children cortical hyperexcitability S1–S2 paradigm |
| title | Unveiling the Role of Contingent Negative Variation (CNV) in Migraine: A Review of Electrophysiological Studies in Adults and Children |
| title_full | Unveiling the Role of Contingent Negative Variation (CNV) in Migraine: A Review of Electrophysiological Studies in Adults and Children |
| title_fullStr | Unveiling the Role of Contingent Negative Variation (CNV) in Migraine: A Review of Electrophysiological Studies in Adults and Children |
| title_full_unstemmed | Unveiling the Role of Contingent Negative Variation (CNV) in Migraine: A Review of Electrophysiological Studies in Adults and Children |
| title_short | Unveiling the Role of Contingent Negative Variation (CNV) in Migraine: A Review of Electrophysiological Studies in Adults and Children |
| title_sort | unveiling the role of contingent negative variation cnv in migraine a review of electrophysiological studies in adults and children |
| topic | Contingent Negative Variation (CNV) migraine without aura migraine cycle children cortical hyperexcitability S1–S2 paradigm |
| url | https://www.mdpi.com/2227-9059/11/11/3030 |
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