Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors
Abstract Increased expression of the small nucleolar RNA host gene 6 (SNHG6) has been reported in different cancers, such as hepatocellular carcinoma, colorectal cancer, and lung cancer. The high expression level of SNHG6 is associated with tumor progression and poor prognosis. This paper provides a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12935-020-01303-x |
| _version_ | 1818325715658997760 |
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| author | Hui-shan Wang Wen Zhang Han-long Zhu Quan-peng Li Lin Miao |
| author_facet | Hui-shan Wang Wen Zhang Han-long Zhu Quan-peng Li Lin Miao |
| author_sort | Hui-shan Wang |
| collection | DOAJ |
| description | Abstract Increased expression of the small nucleolar RNA host gene 6 (SNHG6) has been reported in different cancers, such as hepatocellular carcinoma, colorectal cancer, and lung cancer. The high expression level of SNHG6 is associated with tumor progression and poor prognosis. This paper provides an overview of recent studies on the oncogenic role and potential clinical utilities of SNHG6. Upregulated SNHG6 arrests tumor cell cycle and reduces apoptosis but promotes migration, invasion, metastasis, epithelial-mesenchymal transition (EMT), and chemoresistance in tumors. Mechanically, SNHG6 primarily sponges tumor suppressor microRNA (miRNA), functioning as a competing endogenous RNA. Once sponged, miRNA is unable to degrade, silence, or hamper the translation of its downstream, mostly oncogenic genes, ultimately driving cancer-related processes. Thus, SNHG6 might serve as a biomarker for cancer diagnosis and prognosis. |
| first_indexed | 2024-12-13T11:48:53Z |
| format | Article |
| id | doaj.art-d475665a63274fd09e361cd8aa91e9f0 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-13T11:48:53Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-d475665a63274fd09e361cd8aa91e9f02022-12-21T23:47:25ZengBMCCancer Cell International1475-28672020-06-0120111010.1186/s12935-020-01303-xLong noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumorsHui-shan Wang0Wen Zhang1Han-long Zhu2Quan-peng Li3Lin Miao4Nanjing Medical UniversityNanjing Medical UniversityNanjing Medical UniversityMedical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical UniversityNanjing Medical UniversityAbstract Increased expression of the small nucleolar RNA host gene 6 (SNHG6) has been reported in different cancers, such as hepatocellular carcinoma, colorectal cancer, and lung cancer. The high expression level of SNHG6 is associated with tumor progression and poor prognosis. This paper provides an overview of recent studies on the oncogenic role and potential clinical utilities of SNHG6. Upregulated SNHG6 arrests tumor cell cycle and reduces apoptosis but promotes migration, invasion, metastasis, epithelial-mesenchymal transition (EMT), and chemoresistance in tumors. Mechanically, SNHG6 primarily sponges tumor suppressor microRNA (miRNA), functioning as a competing endogenous RNA. Once sponged, miRNA is unable to degrade, silence, or hamper the translation of its downstream, mostly oncogenic genes, ultimately driving cancer-related processes. Thus, SNHG6 might serve as a biomarker for cancer diagnosis and prognosis.http://link.springer.com/article/10.1186/s12935-020-01303-xLong non-coding RNASNHG6Competing endogenous RNATumors |
| spellingShingle | Hui-shan Wang Wen Zhang Han-long Zhu Quan-peng Li Lin Miao Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors Cancer Cell International Long non-coding RNA SNHG6 Competing endogenous RNA Tumors |
| title | Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors |
| title_full | Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors |
| title_fullStr | Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors |
| title_full_unstemmed | Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors |
| title_short | Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors |
| title_sort | long noncoding rna snhg6 mainly functions as a competing endogenous rna in human tumors |
| topic | Long non-coding RNA SNHG6 Competing endogenous RNA Tumors |
| url | http://link.springer.com/article/10.1186/s12935-020-01303-x |
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