Antizyme inhibitor family: biological and translational research implications
Abstract Metabolism of polyamines is of critical importance to physiological processes. Ornithine decarboxylase (ODC) antizyme inhibitors (AZINs) are capable of interacting with antizymes (AZs), thereby releasing ODC from ODC-AZs complex, and promote polyamine biosynthesis. AZINs regulate reproducti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01445-1 |
| _version_ | 1797363123075678208 |
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| author | Qiaohui Feng Huijie Wang Youcheng Shao Xiaoyan Xu |
| author_facet | Qiaohui Feng Huijie Wang Youcheng Shao Xiaoyan Xu |
| author_sort | Qiaohui Feng |
| collection | DOAJ |
| description | Abstract Metabolism of polyamines is of critical importance to physiological processes. Ornithine decarboxylase (ODC) antizyme inhibitors (AZINs) are capable of interacting with antizymes (AZs), thereby releasing ODC from ODC-AZs complex, and promote polyamine biosynthesis. AZINs regulate reproduction, embryonic development, fibrogenesis and tumorigenesis through polyamine and other signaling pathways. Dysregulation of AZINs has involved in multiple human diseases, especially malignant tumors. Adenosine-to-inosine (A-to-I) RNA editing is the most common type of post-transcriptional nucleotide modification in humans. Additionally, the high frequencies of RNA-edited AZIN1 in human cancers correlates with increase of cancer cell proliferation, enhancement of cancer cell stemness, and promotion of tumor angiogenesis. In this review, we summarize the current knowledge on the various contribution of AZINs related with potential cancer promotion, cancer stemness, microenvironment and RNA modification, especially underlying molecular mechanisms, and furthermore explored its promising implication for cancer diagnosis and treatment. |
| first_indexed | 2024-03-08T16:15:41Z |
| format | Article |
| id | doaj.art-d476504b3d494b87bcecc2f8d294bc12 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-08T16:15:41Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-d476504b3d494b87bcecc2f8d294bc122024-01-07T12:36:42ZengBMCCell Communication and Signaling1478-811X2024-01-0122111410.1186/s12964-023-01445-1Antizyme inhibitor family: biological and translational research implicationsQiaohui Feng0Huijie Wang1Youcheng Shao2Xiaoyan Xu3Department of Breast Surgery, The First Hospital of China Medical UniversityDepartment of Pathophysiology, College of Basic Medical Science, China Medical UniversityDepartment of Pathophysiology, College of Basic Medical Science, China Medical UniversityDepartment of Pathophysiology, College of Basic Medical Science, China Medical UniversityAbstract Metabolism of polyamines is of critical importance to physiological processes. Ornithine decarboxylase (ODC) antizyme inhibitors (AZINs) are capable of interacting with antizymes (AZs), thereby releasing ODC from ODC-AZs complex, and promote polyamine biosynthesis. AZINs regulate reproduction, embryonic development, fibrogenesis and tumorigenesis through polyamine and other signaling pathways. Dysregulation of AZINs has involved in multiple human diseases, especially malignant tumors. Adenosine-to-inosine (A-to-I) RNA editing is the most common type of post-transcriptional nucleotide modification in humans. Additionally, the high frequencies of RNA-edited AZIN1 in human cancers correlates with increase of cancer cell proliferation, enhancement of cancer cell stemness, and promotion of tumor angiogenesis. In this review, we summarize the current knowledge on the various contribution of AZINs related with potential cancer promotion, cancer stemness, microenvironment and RNA modification, especially underlying molecular mechanisms, and furthermore explored its promising implication for cancer diagnosis and treatment.https://doi.org/10.1186/s12964-023-01445-1Antizyme inhibitors (AZINs)PolyamineRNA editingMicroenvironmentTherapy |
| spellingShingle | Qiaohui Feng Huijie Wang Youcheng Shao Xiaoyan Xu Antizyme inhibitor family: biological and translational research implications Cell Communication and Signaling Antizyme inhibitors (AZINs) Polyamine RNA editing Microenvironment Therapy |
| title | Antizyme inhibitor family: biological and translational research implications |
| title_full | Antizyme inhibitor family: biological and translational research implications |
| title_fullStr | Antizyme inhibitor family: biological and translational research implications |
| title_full_unstemmed | Antizyme inhibitor family: biological and translational research implications |
| title_short | Antizyme inhibitor family: biological and translational research implications |
| title_sort | antizyme inhibitor family biological and translational research implications |
| topic | Antizyme inhibitors (AZINs) Polyamine RNA editing Microenvironment Therapy |
| url | https://doi.org/10.1186/s12964-023-01445-1 |
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