Segmentectomy for clinically early‐stage primary squamous cell carcinoma of the lung
Abstract Background Squamous cell carcinoma of the lung—the second most common subtype of lung cancer—has a poorer prognosis than lung adenocarcinoma. However, in contrast to lobectomy, the oncological outcomes after segmentectomy for primary squamous cell carcinomas remain unknown; hence, this stud...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-12-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.14707 |
| _version_ | 1798006698924834816 |
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| author | Atsushi Kagimoto Yasuhiro Tsutani Yoshihisa Shimada Takahiro Mimae Yoshihiro Miyata Hiroyuki Ito Haruhiko Nakayama Norihiko Ikeda Morihito Okada |
| author_facet | Atsushi Kagimoto Yasuhiro Tsutani Yoshihisa Shimada Takahiro Mimae Yoshihiro Miyata Hiroyuki Ito Haruhiko Nakayama Norihiko Ikeda Morihito Okada |
| author_sort | Atsushi Kagimoto |
| collection | DOAJ |
| description | Abstract Background Squamous cell carcinoma of the lung—the second most common subtype of lung cancer—has a poorer prognosis than lung adenocarcinoma. However, in contrast to lobectomy, the oncological outcomes after segmentectomy for primary squamous cell carcinomas remain unknown; hence, this study investigated these outcomes. Methods Patients who underwent lobectomy or segmentectomy for clinically node‐negative primary lung squamous cell carcinoma with a whole tumor size of ≤ 30 mm on preoperative computed tomography scan during April 2010 to December 2020 were included in this study. The cumulative incidence of recurrence (CIR) among all included patients and propensity score‐matched patients were compared using the Gray method. Multivariate analysis using propensity scores and surgical procedures was performed using the Fine and Gray method. Results Overall, 230 patients were included in this study; of these, 172 (74.8%) underwent lobectomy and 58 (25.2%) underwent segmentectomy. No significant differences were observed in the CIR between patients who underwent lobectomy and those who underwent segmentectomy (5‐year rate 18.1% vs. 14.2%; p = 0.787). Moreover, no significant differences in CIR were observed between the propensity score‐matched patients who underwent lobectomy (n = 43) and those who underwent segmentectomy (n = 43) (8.6% vs. 8.0%; p = 0.571). Multivariable analysis was performed for CIR using the propensity score; it revealed that segmentectomy was not a significant predictor of worse CIR (hazard ratio, 0.987; p = 0.980). Conclusions Segmentectomy may be feasible for treating clinically early‐stage lung squamous cell carcinoma; its oncological outcomes are similar to those of lobectomy. |
| first_indexed | 2024-04-11T12:58:45Z |
| format | Article |
| id | doaj.art-d4768ce474d84fdb9d9bfef95ed54d5f |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-11T12:58:45Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-d4768ce474d84fdb9d9bfef95ed54d5f2022-12-22T04:23:00ZengWileyThoracic Cancer1759-77061759-77142022-12-0113243477348510.1111/1759-7714.14707Segmentectomy for clinically early‐stage primary squamous cell carcinoma of the lungAtsushi Kagimoto0Yasuhiro Tsutani1Yoshihisa Shimada2Takahiro Mimae3Yoshihiro Miyata4Hiroyuki Ito5Haruhiko Nakayama6Norihiko Ikeda7Morihito Okada8Department of Surgical Oncology Hiroshima University Hiroshima JapanDepartment of Surgical Oncology Hiroshima University Hiroshima JapanDepartment of Surgery Tokyo Medical University Tokyo JapanDepartment of Surgical Oncology Hiroshima University Hiroshima JapanDepartment of Surgical Oncology Hiroshima University Hiroshima JapanDepartment of Thoracic Surgery Kanagawa Cancer Center Yokohama JapanDepartment of Thoracic Surgery Kanagawa Cancer Center Yokohama JapanDepartment of Surgery Tokyo Medical University Tokyo JapanDepartment of Surgical Oncology Hiroshima University Hiroshima JapanAbstract Background Squamous cell carcinoma of the lung—the second most common subtype of lung cancer—has a poorer prognosis than lung adenocarcinoma. However, in contrast to lobectomy, the oncological outcomes after segmentectomy for primary squamous cell carcinomas remain unknown; hence, this study investigated these outcomes. Methods Patients who underwent lobectomy or segmentectomy for clinically node‐negative primary lung squamous cell carcinoma with a whole tumor size of ≤ 30 mm on preoperative computed tomography scan during April 2010 to December 2020 were included in this study. The cumulative incidence of recurrence (CIR) among all included patients and propensity score‐matched patients were compared using the Gray method. Multivariate analysis using propensity scores and surgical procedures was performed using the Fine and Gray method. Results Overall, 230 patients were included in this study; of these, 172 (74.8%) underwent lobectomy and 58 (25.2%) underwent segmentectomy. No significant differences were observed in the CIR between patients who underwent lobectomy and those who underwent segmentectomy (5‐year rate 18.1% vs. 14.2%; p = 0.787). Moreover, no significant differences in CIR were observed between the propensity score‐matched patients who underwent lobectomy (n = 43) and those who underwent segmentectomy (n = 43) (8.6% vs. 8.0%; p = 0.571). Multivariable analysis was performed for CIR using the propensity score; it revealed that segmentectomy was not a significant predictor of worse CIR (hazard ratio, 0.987; p = 0.980). Conclusions Segmentectomy may be feasible for treating clinically early‐stage lung squamous cell carcinoma; its oncological outcomes are similar to those of lobectomy.https://doi.org/10.1111/1759-7714.14707lobectomylung cancersegmentectomysquamous cell carcinoma |
| spellingShingle | Atsushi Kagimoto Yasuhiro Tsutani Yoshihisa Shimada Takahiro Mimae Yoshihiro Miyata Hiroyuki Ito Haruhiko Nakayama Norihiko Ikeda Morihito Okada Segmentectomy for clinically early‐stage primary squamous cell carcinoma of the lung Thoracic Cancer lobectomy lung cancer segmentectomy squamous cell carcinoma |
| title | Segmentectomy for clinically early‐stage primary squamous cell carcinoma of the lung |
| title_full | Segmentectomy for clinically early‐stage primary squamous cell carcinoma of the lung |
| title_fullStr | Segmentectomy for clinically early‐stage primary squamous cell carcinoma of the lung |
| title_full_unstemmed | Segmentectomy for clinically early‐stage primary squamous cell carcinoma of the lung |
| title_short | Segmentectomy for clinically early‐stage primary squamous cell carcinoma of the lung |
| title_sort | segmentectomy for clinically early stage primary squamous cell carcinoma of the lung |
| topic | lobectomy lung cancer segmentectomy squamous cell carcinoma |
| url | https://doi.org/10.1111/1759-7714.14707 |
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