Molecular mechanisms of pain in acute pancreatitis: recent basic research advances and therapeutic implications
Although severe abdominal pain is the main symptom of acute pancreatitis, its mechanisms are poorly understood. An emerging body of literature evidence indicates that neurogenic inflammation might play a major role in modulating the perception of pain from the pancreas. Neurogenic inflammation is th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1331438/full |
| _version_ | 1797382957401374720 |
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| author | Yongzi Wu Chenxia Han Rong Luo Wenhao Cai Qing Xia Ruotian Jiang Pawel E. Ferdek Tingting Liu Wei Huang Wei Huang Wei Huang |
| author_facet | Yongzi Wu Chenxia Han Rong Luo Wenhao Cai Qing Xia Ruotian Jiang Pawel E. Ferdek Tingting Liu Wei Huang Wei Huang Wei Huang |
| author_sort | Yongzi Wu |
| collection | DOAJ |
| description | Although severe abdominal pain is the main symptom of acute pancreatitis, its mechanisms are poorly understood. An emerging body of literature evidence indicates that neurogenic inflammation might play a major role in modulating the perception of pain from the pancreas. Neurogenic inflammation is the result of a crosstalk between injured pancreatic tissue and activated neurons, which leads to an auto-amplification loop between inflammation and pain during the progression of acute pancreatitis. In this review, we summarize recent findings on the role of neuropeptides, ion channels, and the endocannabinoid system in acute pancreatitis-related pain. We also highlight potential therapeutic strategies that could be applied for managing severe pain in this disease. |
| first_indexed | 2024-03-08T21:13:45Z |
| format | Article |
| id | doaj.art-d476a999c3a544a4a180474a0081fc91 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-03-08T21:13:45Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-d476a999c3a544a4a180474a0081fc912023-12-22T04:39:33ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992023-12-011610.3389/fnmol.2023.13314381331438Molecular mechanisms of pain in acute pancreatitis: recent basic research advances and therapeutic implicationsYongzi Wu0Chenxia Han1Rong Luo2Wenhao Cai3Qing Xia4Ruotian Jiang5Pawel E. Ferdek6Tingting Liu7Wei Huang8Wei Huang9Wei Huang10West China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, ChinaWest China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, ChinaWest China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, ChinaWest China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, PolandWest China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, ChinaWest China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, ChinaInstitutes for Systems Genetics and Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaWest China Biobank, West China Hospital, Sichuan University, Chengdu, ChinaAlthough severe abdominal pain is the main symptom of acute pancreatitis, its mechanisms are poorly understood. An emerging body of literature evidence indicates that neurogenic inflammation might play a major role in modulating the perception of pain from the pancreas. Neurogenic inflammation is the result of a crosstalk between injured pancreatic tissue and activated neurons, which leads to an auto-amplification loop between inflammation and pain during the progression of acute pancreatitis. In this review, we summarize recent findings on the role of neuropeptides, ion channels, and the endocannabinoid system in acute pancreatitis-related pain. We also highlight potential therapeutic strategies that could be applied for managing severe pain in this disease.https://www.frontiersin.org/articles/10.3389/fnmol.2023.1331438/fullacute pancreatitisvisceral painneuropeptidesion channelsendocannabinoid system |
| spellingShingle | Yongzi Wu Chenxia Han Rong Luo Wenhao Cai Qing Xia Ruotian Jiang Pawel E. Ferdek Tingting Liu Wei Huang Wei Huang Wei Huang Molecular mechanisms of pain in acute pancreatitis: recent basic research advances and therapeutic implications Frontiers in Molecular Neuroscience acute pancreatitis visceral pain neuropeptides ion channels endocannabinoid system |
| title | Molecular mechanisms of pain in acute pancreatitis: recent basic research advances and therapeutic implications |
| title_full | Molecular mechanisms of pain in acute pancreatitis: recent basic research advances and therapeutic implications |
| title_fullStr | Molecular mechanisms of pain in acute pancreatitis: recent basic research advances and therapeutic implications |
| title_full_unstemmed | Molecular mechanisms of pain in acute pancreatitis: recent basic research advances and therapeutic implications |
| title_short | Molecular mechanisms of pain in acute pancreatitis: recent basic research advances and therapeutic implications |
| title_sort | molecular mechanisms of pain in acute pancreatitis recent basic research advances and therapeutic implications |
| topic | acute pancreatitis visceral pain neuropeptides ion channels endocannabinoid system |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1331438/full |
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