| Summary: | <i>Solenostemma argel</i> is a desert medicinal plant indigenous to African countries. This research aims to study the pharmacological properties of <i>Solenostemma argel</i> plant. Aerial parts (leaves and flowers) of <i>Solenostemma argel</i> (Delile) Hayane were tested for antibacterial activity, antioxidant activity, anticancer, and anti-inflammatory activity. Phenolic and flavonoid contents of the plant were characterized. There was an increase in the antioxidant activity of <i>Solenostemma argel</i> extract from 12.16% to 94.37% by increasing concentration from10 µg/mL to 1280 µg/mL. The most sensitive organism was <i>S. epidermidis</i> with chloroform extract. The MTT assay revealed that methanolic extracts of <i>Solenostemma argel</i> showed potent cytotoxic effects on the A549, Caco-2, and MDAMB-231 cell lines, respectively. The anti-inflammatory activity increased by increasing the concentration of methanolic extract of <i>Solenostemma argel</i>, using indomethacin as a standard. Gallic acid was the most abundant phenolic acid, followed by synergic acid and p-coumaric acid, respectively. Catechin, quercetin, luteolin, kaempferol and rutin flavonoids were also found in the methanolic extract. GC-mass analysis showed that aerial parts of <i>Solenostemma argel</i> were rich in 2-(5-methyl-5 vinyl tetrahydro-2-furanyl)-2-propanol (11.63%), hexanoic acid methyl ester (10.93%), 3-dioxolane,4-methyl-2-pentadecyl (9.69%), phenol, 2-(1,1-dimethylethyl) (8.50%). It can be concluded that <i>Solenostemma argel</i> methanolic extract contain natural bioactive constituents with potential medicinal importance such as antioxidants, antimicrobial, anti-inflammatory, and anticancer activities.
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