Pharmacological Activities and Characterization of Phenolic and Flavonoid Compounds in <i>Solenostemma argel</i> Extract
<i>Solenostemma argel</i> is a desert medicinal plant indigenous to African countries. This research aims to study the pharmacological properties of <i>Solenostemma argel</i> plant. Aerial parts (leaves and flowers) of <i>Solenostemma argel</i> (Delile) Hayane wer...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/23/8118 |
| _version_ | 1797462747890319360 |
|---|---|
| author | Rafaat M. Elsanhoty Mohamed S. M. Soliman Yehia A. Khidr Gamal O. O. Hassan Ahmed R. A. Hassan Mohammed Aladhadh Asmaa Abdella |
| author_facet | Rafaat M. Elsanhoty Mohamed S. M. Soliman Yehia A. Khidr Gamal O. O. Hassan Ahmed R. A. Hassan Mohammed Aladhadh Asmaa Abdella |
| author_sort | Rafaat M. Elsanhoty |
| collection | DOAJ |
| description | <i>Solenostemma argel</i> is a desert medicinal plant indigenous to African countries. This research aims to study the pharmacological properties of <i>Solenostemma argel</i> plant. Aerial parts (leaves and flowers) of <i>Solenostemma argel</i> (Delile) Hayane were tested for antibacterial activity, antioxidant activity, anticancer, and anti-inflammatory activity. Phenolic and flavonoid contents of the plant were characterized. There was an increase in the antioxidant activity of <i>Solenostemma argel</i> extract from 12.16% to 94.37% by increasing concentration from10 µg/mL to 1280 µg/mL. The most sensitive organism was <i>S. epidermidis</i> with chloroform extract. The MTT assay revealed that methanolic extracts of <i>Solenostemma argel</i> showed potent cytotoxic effects on the A549, Caco-2, and MDAMB-231 cell lines, respectively. The anti-inflammatory activity increased by increasing the concentration of methanolic extract of <i>Solenostemma argel</i>, using indomethacin as a standard. Gallic acid was the most abundant phenolic acid, followed by synergic acid and p-coumaric acid, respectively. Catechin, quercetin, luteolin, kaempferol and rutin flavonoids were also found in the methanolic extract. GC-mass analysis showed that aerial parts of <i>Solenostemma argel</i> were rich in 2-(5-methyl-5 vinyl tetrahydro-2-furanyl)-2-propanol (11.63%), hexanoic acid methyl ester (10.93%), 3-dioxolane,4-methyl-2-pentadecyl (9.69%), phenol, 2-(1,1-dimethylethyl) (8.50%). It can be concluded that <i>Solenostemma argel</i> methanolic extract contain natural bioactive constituents with potential medicinal importance such as antioxidants, antimicrobial, anti-inflammatory, and anticancer activities. |
| first_indexed | 2024-03-09T17:41:03Z |
| format | Article |
| id | doaj.art-d476ea95233e4efd9462c2d85322576f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T17:41:03Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d476ea95233e4efd9462c2d85322576f2023-11-24T11:36:54ZengMDPI AGMolecules1420-30492022-11-012723811810.3390/molecules27238118Pharmacological Activities and Characterization of Phenolic and Flavonoid Compounds in <i>Solenostemma argel</i> ExtractRafaat M. Elsanhoty0Mohamed S. M. Soliman1Yehia A. Khidr2Gamal O. O. Hassan3Ahmed R. A. Hassan4Mohammed Aladhadh5Asmaa Abdella6Department of Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City (USC), Sadat City 32897, EgyptDepartment of Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City (USC), Sadat City 32897, EgyptDepartment of Plant Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City (USC), Sadat City 32897, EgyptMedicinal and Aromatic Plants Department, Natural Products Unit, Desert Research Center, 1 Mathaf El-Matarya St., El-Matareya, Cairo 11753, EgyptMedicinal and Aromatic Plants Department, Natural Products Unit, Desert Research Center, 1 Mathaf El-Matarya St., El-Matareya, Cairo 11753, EgyptDepartment of Food Science and Human Nutrition, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah 51452, Saudi ArabiaDepartment of Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City (USC), Sadat City 32897, Egypt<i>Solenostemma argel</i> is a desert medicinal plant indigenous to African countries. This research aims to study the pharmacological properties of <i>Solenostemma argel</i> plant. Aerial parts (leaves and flowers) of <i>Solenostemma argel</i> (Delile) Hayane were tested for antibacterial activity, antioxidant activity, anticancer, and anti-inflammatory activity. Phenolic and flavonoid contents of the plant were characterized. There was an increase in the antioxidant activity of <i>Solenostemma argel</i> extract from 12.16% to 94.37% by increasing concentration from10 µg/mL to 1280 µg/mL. The most sensitive organism was <i>S. epidermidis</i> with chloroform extract. The MTT assay revealed that methanolic extracts of <i>Solenostemma argel</i> showed potent cytotoxic effects on the A549, Caco-2, and MDAMB-231 cell lines, respectively. The anti-inflammatory activity increased by increasing the concentration of methanolic extract of <i>Solenostemma argel</i>, using indomethacin as a standard. Gallic acid was the most abundant phenolic acid, followed by synergic acid and p-coumaric acid, respectively. Catechin, quercetin, luteolin, kaempferol and rutin flavonoids were also found in the methanolic extract. GC-mass analysis showed that aerial parts of <i>Solenostemma argel</i> were rich in 2-(5-methyl-5 vinyl tetrahydro-2-furanyl)-2-propanol (11.63%), hexanoic acid methyl ester (10.93%), 3-dioxolane,4-methyl-2-pentadecyl (9.69%), phenol, 2-(1,1-dimethylethyl) (8.50%). It can be concluded that <i>Solenostemma argel</i> methanolic extract contain natural bioactive constituents with potential medicinal importance such as antioxidants, antimicrobial, anti-inflammatory, and anticancer activities.https://www.mdpi.com/1420-3049/27/23/8118<i>Solenostemma argel</i>antioxidantanti-inflammatoryanticancerantimicrobial |
| spellingShingle | Rafaat M. Elsanhoty Mohamed S. M. Soliman Yehia A. Khidr Gamal O. O. Hassan Ahmed R. A. Hassan Mohammed Aladhadh Asmaa Abdella Pharmacological Activities and Characterization of Phenolic and Flavonoid Compounds in <i>Solenostemma argel</i> Extract Molecules <i>Solenostemma argel</i> antioxidant anti-inflammatory anticancer antimicrobial |
| title | Pharmacological Activities and Characterization of Phenolic and Flavonoid Compounds in <i>Solenostemma argel</i> Extract |
| title_full | Pharmacological Activities and Characterization of Phenolic and Flavonoid Compounds in <i>Solenostemma argel</i> Extract |
| title_fullStr | Pharmacological Activities and Characterization of Phenolic and Flavonoid Compounds in <i>Solenostemma argel</i> Extract |
| title_full_unstemmed | Pharmacological Activities and Characterization of Phenolic and Flavonoid Compounds in <i>Solenostemma argel</i> Extract |
| title_short | Pharmacological Activities and Characterization of Phenolic and Flavonoid Compounds in <i>Solenostemma argel</i> Extract |
| title_sort | pharmacological activities and characterization of phenolic and flavonoid compounds in i solenostemma argel i extract |
| topic | <i>Solenostemma argel</i> antioxidant anti-inflammatory anticancer antimicrobial |
| url | https://www.mdpi.com/1420-3049/27/23/8118 |
| work_keys_str_mv | AT rafaatmelsanhoty pharmacologicalactivitiesandcharacterizationofphenolicandflavonoidcompoundsinisolenostemmaargeliextract AT mohamedsmsoliman pharmacologicalactivitiesandcharacterizationofphenolicandflavonoidcompoundsinisolenostemmaargeliextract AT yehiaakhidr pharmacologicalactivitiesandcharacterizationofphenolicandflavonoidcompoundsinisolenostemmaargeliextract AT gamaloohassan pharmacologicalactivitiesandcharacterizationofphenolicandflavonoidcompoundsinisolenostemmaargeliextract AT ahmedrahassan pharmacologicalactivitiesandcharacterizationofphenolicandflavonoidcompoundsinisolenostemmaargeliextract AT mohammedaladhadh pharmacologicalactivitiesandcharacterizationofphenolicandflavonoidcompoundsinisolenostemmaargeliextract AT asmaaabdella pharmacologicalactivitiesandcharacterizationofphenolicandflavonoidcompoundsinisolenostemmaargeliextract |