Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19
Background COVID-19 is characterized by the presence of oxidative stress. Vitamin D status has been reviewed as one of the factors that may affect disease severity. The aim of this study was to assess the relationship between serum vitamin D levels, oxidative stress markers and disease severity in h...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Redox Report |
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| Online Access: | http://dx.doi.org/10.1080/13510002.2021.1999126 |
| _version_ | 1819099658396368896 |
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| author | Emilija Atanasovska Marija Petrusevska Dragica Zendelovska Katerina Spasovska Milena Stevanovikj Katerina Kasapinova Kalina Gjorgjievska Nikola Labachevski |
| author_facet | Emilija Atanasovska Marija Petrusevska Dragica Zendelovska Katerina Spasovska Milena Stevanovikj Katerina Kasapinova Kalina Gjorgjievska Nikola Labachevski |
| author_sort | Emilija Atanasovska |
| collection | DOAJ |
| description | Background COVID-19 is characterized by the presence of oxidative stress. Vitamin D status has been reviewed as one of the factors that may affect disease severity. The aim of this study was to assess the relationship between serum vitamin D levels, oxidative stress markers and disease severity in hospitalized COVID-19 patients. Methods Vitamin D levels were measured in 33 patients with COVID-19. The total antioxidant power and plasma peroxides were determined in serum. Results Severe COVID-19 patients have lower vitamin D levels (18.39 ± 2.29 ng/mL vs. 28.47 ± 3.05 ng/mL, p < .05) and higher oxidative stress compared to the moderate group. When divided according to serum vitamin D levels, significantly higher values of LDH (604.8 ± 76.98 IU/mL vs. 261.57 ± 47.33 IU/mL) and D-dimer (5978 ± 2028ng/mL vs. 977.7 ± 172 ng/mL) were obtained in the group with vitamin D below 30 ng/mL, followed with significantly higher levels of plasma peroxides (d-ROMs: 414.9 ± 15.82 U.Carr vs. 352.4 ± 18.77 U.Carr; p < .05) and oxidative stress index (OSI: 92.25 ± 6.60 vs. 51.89 ± 6.45; p < .001). Conclusion The presented data provide a justification to consider vitamin D as an important factor that could ameliorate disease severity through its anti-inflammatory and antioxidant effects. |
| first_indexed | 2024-12-22T00:50:23Z |
| format | Article |
| id | doaj.art-d4775f1d2b254896a1412678d76afce8 |
| institution | Directory Open Access Journal |
| issn | 1351-0002 1743-2928 |
| language | English |
| last_indexed | 2024-12-22T00:50:23Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Redox Report |
| spelling | doaj.art-d4775f1d2b254896a1412678d76afce82022-12-21T18:44:27ZengTaylor & Francis GroupRedox Report1351-00021743-29282021-01-0126118418910.1080/13510002.2021.19991261999126Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19Emilija Atanasovska0Marija Petrusevska1Dragica Zendelovska2Katerina Spasovska3Milena Stevanovikj4Katerina Kasapinova5Kalina Gjorgjievska6Nikola Labachevski7Faculty of Medicine, University of Ss Cyril and Methodius, Institute of Preclinical and Clinical Pharmacology and ToxicologyFaculty of Medicine, University of Ss Cyril and Methodius, Institute of Preclinical and Clinical Pharmacology and ToxicologyFaculty of Medicine, University of Ss Cyril and Methodius, Institute of Preclinical and Clinical Pharmacology and ToxicologyIntensive Care Unit, University Clinic for Infectious Diseases and Febrile ConditionsIntensive Care Unit, University Clinic for Infectious Diseases and Febrile ConditionsIntensive Care Unit, University Surgery Clinic ‘St.Naum Ohridski'Faculty of Medicine, University of Ss Cyril and Methodius, Institute of Preclinical and Clinical Pharmacology and ToxicologyFaculty of Medicine, University of Ss Cyril and Methodius, Institute of Preclinical and Clinical Pharmacology and ToxicologyBackground COVID-19 is characterized by the presence of oxidative stress. Vitamin D status has been reviewed as one of the factors that may affect disease severity. The aim of this study was to assess the relationship between serum vitamin D levels, oxidative stress markers and disease severity in hospitalized COVID-19 patients. Methods Vitamin D levels were measured in 33 patients with COVID-19. The total antioxidant power and plasma peroxides were determined in serum. Results Severe COVID-19 patients have lower vitamin D levels (18.39 ± 2.29 ng/mL vs. 28.47 ± 3.05 ng/mL, p < .05) and higher oxidative stress compared to the moderate group. When divided according to serum vitamin D levels, significantly higher values of LDH (604.8 ± 76.98 IU/mL vs. 261.57 ± 47.33 IU/mL) and D-dimer (5978 ± 2028ng/mL vs. 977.7 ± 172 ng/mL) were obtained in the group with vitamin D below 30 ng/mL, followed with significantly higher levels of plasma peroxides (d-ROMs: 414.9 ± 15.82 U.Carr vs. 352.4 ± 18.77 U.Carr; p < .05) and oxidative stress index (OSI: 92.25 ± 6.60 vs. 51.89 ± 6.45; p < .001). Conclusion The presented data provide a justification to consider vitamin D as an important factor that could ameliorate disease severity through its anti-inflammatory and antioxidant effects.http://dx.doi.org/10.1080/13510002.2021.1999126covid-19vitamin doxidative stressplasma peroxidesdisease severityantioxidantsinflammation |
| spellingShingle | Emilija Atanasovska Marija Petrusevska Dragica Zendelovska Katerina Spasovska Milena Stevanovikj Katerina Kasapinova Kalina Gjorgjievska Nikola Labachevski Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19 Redox Report covid-19 vitamin d oxidative stress plasma peroxides disease severity antioxidants inflammation |
| title | Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19 |
| title_full | Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19 |
| title_fullStr | Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19 |
| title_full_unstemmed | Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19 |
| title_short | Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19 |
| title_sort | vitamin d levels and oxidative stress markers in patients hospitalized with covid 19 |
| topic | covid-19 vitamin d oxidative stress plasma peroxides disease severity antioxidants inflammation |
| url | http://dx.doi.org/10.1080/13510002.2021.1999126 |
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