The structural basis of promiscuity in small multidrug resistance transporters
Gdx-Clo is a bacterial transporter from the small multidrug resistance (SMR) family. Here, the authors use solid supported membrane electrophysiology to characterize Gdx-Clo functionally and report crystal structures of Gdx-Clo which confirm the dual topology architecture and offer insight into subs...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19820-8 |
| _version_ | 1818992862311743488 |
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| author | Ali A. Kermani Christian B. Macdonald Olive E. Burata B. Ben Koff Akiko Koide Eric Denbaum Shohei Koide Randy B. Stockbridge |
| author_facet | Ali A. Kermani Christian B. Macdonald Olive E. Burata B. Ben Koff Akiko Koide Eric Denbaum Shohei Koide Randy B. Stockbridge |
| author_sort | Ali A. Kermani |
| collection | DOAJ |
| description | Gdx-Clo is a bacterial transporter from the small multidrug resistance (SMR) family. Here, the authors use solid supported membrane electrophysiology to characterize Gdx-Clo functionally and report crystal structures of Gdx-Clo which confirm the dual topology architecture and offer insight into substrate binding and transport mechanism. |
| first_indexed | 2024-12-20T20:32:54Z |
| format | Article |
| id | doaj.art-d4785d992fee4f28884dcfc5aaeb641b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:32:54Z |
| publishDate | 2020-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d4785d992fee4f28884dcfc5aaeb641b2022-12-21T19:27:19ZengNature PortfolioNature Communications2041-17232020-11-011111910.1038/s41467-020-19820-8The structural basis of promiscuity in small multidrug resistance transportersAli A. Kermani0Christian B. Macdonald1Olive E. Burata2B. Ben Koff3Akiko Koide4Eric Denbaum5Shohei Koide6Randy B. Stockbridge7Department of Molecular, Cellular, and Developmental Biology, University of MichiganProgram in Biophysics, University of MichiganProgram in Chemical Biology, University of MichiganDepartment of Molecular, Cellular, and Developmental Biology, University of MichiganLaura and Isaac Perlmutter Cancer Center, New York University Langone Medical CenterLaura and Isaac Perlmutter Cancer Center, New York University Langone Medical CenterLaura and Isaac Perlmutter Cancer Center, New York University Langone Medical CenterDepartment of Molecular, Cellular, and Developmental Biology, University of MichiganGdx-Clo is a bacterial transporter from the small multidrug resistance (SMR) family. Here, the authors use solid supported membrane electrophysiology to characterize Gdx-Clo functionally and report crystal structures of Gdx-Clo which confirm the dual topology architecture and offer insight into substrate binding and transport mechanism.https://doi.org/10.1038/s41467-020-19820-8 |
| spellingShingle | Ali A. Kermani Christian B. Macdonald Olive E. Burata B. Ben Koff Akiko Koide Eric Denbaum Shohei Koide Randy B. Stockbridge The structural basis of promiscuity in small multidrug resistance transporters Nature Communications |
| title | The structural basis of promiscuity in small multidrug resistance transporters |
| title_full | The structural basis of promiscuity in small multidrug resistance transporters |
| title_fullStr | The structural basis of promiscuity in small multidrug resistance transporters |
| title_full_unstemmed | The structural basis of promiscuity in small multidrug resistance transporters |
| title_short | The structural basis of promiscuity in small multidrug resistance transporters |
| title_sort | structural basis of promiscuity in small multidrug resistance transporters |
| url | https://doi.org/10.1038/s41467-020-19820-8 |
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