The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomas
Next generation sequencing (NGS) is a technology that broadens the horizon of knowledge of several somatic pathologies, especially in oncological and oncohematological pathology. In the case of NHL, the understanding of the mechanisms of tumorigenesis, tumor proliferation and the identification of g...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1275327/full |
| _version_ | 1827766652704391168 |
|---|---|
| author | Victor Tomacinschii Victor Tomacinschii Adrian Mosquera Orgueira Adrian Mosquera Orgueira Carlos Aliste Santos Maria Robu Sanda Buruiana Maximo Francisco Fraga Rodriguez Maximo Francisco Fraga Rodriguez Maximo Francisco Fraga Rodriguez |
| author_facet | Victor Tomacinschii Victor Tomacinschii Adrian Mosquera Orgueira Adrian Mosquera Orgueira Carlos Aliste Santos Maria Robu Sanda Buruiana Maximo Francisco Fraga Rodriguez Maximo Francisco Fraga Rodriguez Maximo Francisco Fraga Rodriguez |
| author_sort | Victor Tomacinschii |
| collection | DOAJ |
| description | Next generation sequencing (NGS) is a technology that broadens the horizon of knowledge of several somatic pathologies, especially in oncological and oncohematological pathology. In the case of NHL, the understanding of the mechanisms of tumorigenesis, tumor proliferation and the identification of genetic markers specific to different lymphoma subtypes led to more accurate classification and diagnosis. Similarly, the data obtained through NGS allowed the identification of recurrent somatic mutations that can serve as therapeutic targets that can be inhibited and thus reducing the rate of resistant cases. The article’s purpose is to offer a comprehensive overview of the best ways of integrating of next-generation sequencing technologies for diagnosis, prognosis, classification, and selection of optimal therapy from the perspective of tailor-made medicine. |
| first_indexed | 2024-03-11T11:44:59Z |
| format | Article |
| id | doaj.art-d47864ff8c8b43699c65ac818dc39a1b |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-11T11:44:59Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-d47864ff8c8b43699c65ac818dc39a1b2023-11-09T16:15:22ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-11-011310.3389/fonc.2023.12753271275327The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomasVictor Tomacinschii0Victor Tomacinschii1Adrian Mosquera Orgueira2Adrian Mosquera Orgueira3Carlos Aliste Santos4Maria Robu5Sanda Buruiana6Maximo Francisco Fraga Rodriguez7Maximo Francisco Fraga Rodriguez8Maximo Francisco Fraga Rodriguez9Department of Hematology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, MoldovaDepartment of Hematology, Public Medical Sanitary Institution (PMSI) Institute of Oncology, Chisinau, MoldovaUniversity Hospital of Santiago de Compostela, Servizo Galego de Saude (SERGAS), Santiago de Compostela, SpainHealth Research Institute of Santiago de Compostela, Santiago de Compostela, SpainUniversity Hospital of Santiago de Compostela, Servizo Galego de Saude (SERGAS), Santiago de Compostela, SpainDepartment of Hematology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, MoldovaDepartment of Hematology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, MoldovaUniversity Hospital of Santiago de Compostela, Servizo Galego de Saude (SERGAS), Santiago de Compostela, SpainHealth Research Institute of Santiago de Compostela, Santiago de Compostela, SpainDepartment of Forensic Sciences, Pathology, Ginecology and Obstetrics and Pediatrics, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, SpainNext generation sequencing (NGS) is a technology that broadens the horizon of knowledge of several somatic pathologies, especially in oncological and oncohematological pathology. In the case of NHL, the understanding of the mechanisms of tumorigenesis, tumor proliferation and the identification of genetic markers specific to different lymphoma subtypes led to more accurate classification and diagnosis. Similarly, the data obtained through NGS allowed the identification of recurrent somatic mutations that can serve as therapeutic targets that can be inhibited and thus reducing the rate of resistant cases. The article’s purpose is to offer a comprehensive overview of the best ways of integrating of next-generation sequencing technologies for diagnosis, prognosis, classification, and selection of optimal therapy from the perspective of tailor-made medicine.https://www.frontiersin.org/articles/10.3389/fonc.2023.1275327/fulllymphomasnon-Hodgkin lymphomasgenomicsdiagnosisnext-generation sequencing |
| spellingShingle | Victor Tomacinschii Victor Tomacinschii Adrian Mosquera Orgueira Adrian Mosquera Orgueira Carlos Aliste Santos Maria Robu Sanda Buruiana Maximo Francisco Fraga Rodriguez Maximo Francisco Fraga Rodriguez Maximo Francisco Fraga Rodriguez The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomas Frontiers in Oncology lymphomas non-Hodgkin lymphomas genomics diagnosis next-generation sequencing |
| title | The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomas |
| title_full | The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomas |
| title_fullStr | The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomas |
| title_full_unstemmed | The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomas |
| title_short | The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomas |
| title_sort | implication of next generation sequencing in the diagnosis and clinical management of non hodgkin lymphomas |
| topic | lymphomas non-Hodgkin lymphomas genomics diagnosis next-generation sequencing |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1275327/full |
| work_keys_str_mv | AT victortomacinschii theimplicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT victortomacinschii theimplicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT adrianmosqueraorgueira theimplicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT adrianmosqueraorgueira theimplicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT carlosalistesantos theimplicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT mariarobu theimplicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT sandaburuiana theimplicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT maximofranciscofragarodriguez theimplicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT maximofranciscofragarodriguez theimplicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT maximofranciscofragarodriguez theimplicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT victortomacinschii implicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT victortomacinschii implicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT adrianmosqueraorgueira implicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT adrianmosqueraorgueira implicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT carlosalistesantos implicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT mariarobu implicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT sandaburuiana implicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT maximofranciscofragarodriguez implicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT maximofranciscofragarodriguez implicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas AT maximofranciscofragarodriguez implicationofnextgenerationsequencinginthediagnosisandclinicalmanagementofnonhodgkinlymphomas |