Monocytes and Macrophages in Spondyloarthritis: Functional Roles and Effects of Current Therapies
Spondyloarthritis (SpA) is a family of chronic inflammatory diseases, being the most prevalent ankylosing spondylitis (AS) and psoriatic arthritis (PsA). These diseases share genetic, clinical and immunological features, such as the implication of human leukocyte antigen (HLA) class I molecule 27 (H...
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MDPI AG
2022-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/3/515 |
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| author | Sara Martínez-Ramos Carlos Rafael-Vidal José M. Pego-Reigosa Samuel García |
| author_facet | Sara Martínez-Ramos Carlos Rafael-Vidal José M. Pego-Reigosa Samuel García |
| author_sort | Sara Martínez-Ramos |
| collection | DOAJ |
| description | Spondyloarthritis (SpA) is a family of chronic inflammatory diseases, being the most prevalent ankylosing spondylitis (AS) and psoriatic arthritis (PsA). These diseases share genetic, clinical and immunological features, such as the implication of human leukocyte antigen (HLA) class I molecule 27 (HLA-B27), the inflammation of peripheral, spine and sacroiliac joints and the presence of extra-articular manifestations (psoriasis, anterior uveitis, enthesitis and inflammatory bowel disease). Monocytes and macrophages are essential cells of the innate immune system and are the first line of defence against external agents. In rheumatic diseases including SpA, the frequency and phenotypic and functional characteristics of both cell types are deregulated and are involved in the pathogenesis of these diseases. In fact, monocytes and macrophages play key roles in the inflammatory processes characteristics of SpA. The aim of this review is analysing the characteristics and functional roles of monocytes and macrophages in these diseases, as well as the impact of different current therapies on these cell types. |
| first_indexed | 2024-03-10T00:03:42Z |
| format | Article |
| id | doaj.art-d4797628334e44bdb5126a978b4975b3 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:03:42Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
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| spelling | doaj.art-d4797628334e44bdb5126a978b4975b32023-11-23T16:13:14ZengMDPI AGCells2073-44092022-02-0111351510.3390/cells11030515Monocytes and Macrophages in Spondyloarthritis: Functional Roles and Effects of Current TherapiesSara Martínez-Ramos0Carlos Rafael-Vidal1José M. Pego-Reigosa2Samuel García3Rheumatology & Immuno-Mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, SpainRheumatology & Immuno-Mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, SpainRheumatology & Immuno-Mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, SpainRheumatology & Immuno-Mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, SpainSpondyloarthritis (SpA) is a family of chronic inflammatory diseases, being the most prevalent ankylosing spondylitis (AS) and psoriatic arthritis (PsA). These diseases share genetic, clinical and immunological features, such as the implication of human leukocyte antigen (HLA) class I molecule 27 (HLA-B27), the inflammation of peripheral, spine and sacroiliac joints and the presence of extra-articular manifestations (psoriasis, anterior uveitis, enthesitis and inflammatory bowel disease). Monocytes and macrophages are essential cells of the innate immune system and are the first line of defence against external agents. In rheumatic diseases including SpA, the frequency and phenotypic and functional characteristics of both cell types are deregulated and are involved in the pathogenesis of these diseases. In fact, monocytes and macrophages play key roles in the inflammatory processes characteristics of SpA. The aim of this review is analysing the characteristics and functional roles of monocytes and macrophages in these diseases, as well as the impact of different current therapies on these cell types.https://www.mdpi.com/2073-4409/11/3/515spondyloarthritismonocytesmacrophagescurrent therapies |
| spellingShingle | Sara Martínez-Ramos Carlos Rafael-Vidal José M. Pego-Reigosa Samuel García Monocytes and Macrophages in Spondyloarthritis: Functional Roles and Effects of Current Therapies Cells spondyloarthritis monocytes macrophages current therapies |
| title | Monocytes and Macrophages in Spondyloarthritis: Functional Roles and Effects of Current Therapies |
| title_full | Monocytes and Macrophages in Spondyloarthritis: Functional Roles and Effects of Current Therapies |
| title_fullStr | Monocytes and Macrophages in Spondyloarthritis: Functional Roles and Effects of Current Therapies |
| title_full_unstemmed | Monocytes and Macrophages in Spondyloarthritis: Functional Roles and Effects of Current Therapies |
| title_short | Monocytes and Macrophages in Spondyloarthritis: Functional Roles and Effects of Current Therapies |
| title_sort | monocytes and macrophages in spondyloarthritis functional roles and effects of current therapies |
| topic | spondyloarthritis monocytes macrophages current therapies |
| url | https://www.mdpi.com/2073-4409/11/3/515 |
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