Genetic targeting of protease activated receptor 2 reduces inflammatory astrogliosis and improves recovery of function after spinal cord injury

Genetic targeting of protease activated receptor 2 reduces inflammatory astrogliosis and improves recovery of function after spinal cord injury

Inflammatory-astrogliosis exacerbates damage in the injured spinal cord and limits repair. Here we identify Protease Activated Receptor 2 (PAR2) as an essential regulator of these events with mice lacking the PAR2 gene showing greater improvements in motor coordination and strength after compression...

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Bibliographic Details
Main Authors: Maja Radulovic, Hyesook Yoon, Jianmin Wu, Karim Mustafa, Michael G. Fehlings, Isobel A. Scarisbrick
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Neurobiology of Disease
Subjects:
Traumatic spinal cord injury
Astrogliosis
Inflammation
Cytokine
GPCR
Serine protease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300413

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