Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures

Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures

Combined antiretroviral therapy (cART) has greatly decreased mortality and morbidity among persons with HIV; however, neurologic impairments remain prevalent, in particular HIV-associated neurocognitive disorders (HANDs). White matter damage persists in cART-treated persons with HIV and may contribu...

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Bibliographic Details
Main Authors: Hubert Monnerie, Micah Romer, Lindsay M. Roth, Caela Long, John S. Millar, Kelly L. Jordan-Sciutto, Judith B. Grinspan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cART
Hand
HIV
myelin
oligodendrocyte
SREBP
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1323431/full

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