The Connectivity Fingerprint of the Human Frontal Cortex, Subthalamic Nucleus, and Striatum
Within the cortico basal ganglia (BG)–thalamic network, the direct and indirect pathways comprise of projections from the cortex to the striatum (STR), whereas the hyperdirect pathway(s) consist of cortical projections toward the subthalamic nucleus (STN). Each pathway possesses a functionally disti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Neuroanatomy |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnana.2018.00060/full |
| _version_ | 1817979318963273728 |
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| author | Bethany R. Isaacs Bethany R. Isaacs Birte U. Forstmann Yasin Temel Yasin Temel Max C. Keuken |
| author_facet | Bethany R. Isaacs Bethany R. Isaacs Birte U. Forstmann Yasin Temel Yasin Temel Max C. Keuken |
| author_sort | Bethany R. Isaacs |
| collection | DOAJ |
| description | Within the cortico basal ganglia (BG)–thalamic network, the direct and indirect pathways comprise of projections from the cortex to the striatum (STR), whereas the hyperdirect pathway(s) consist of cortical projections toward the subthalamic nucleus (STN). Each pathway possesses a functionally distinct role for action selection. The current study quantified and compared the structural connectivity between 17 distinct cortical areas with the STN and STR using 7 Tesla diffusion weighted magnetic resonance imaging (dMRI) and resting-state functional MRI (rs-fMRI) in healthy young subjects. The selection of these cortical areas was based on a literature search focusing on animal tracer studies. The results indicate that, relative to other cortical areas, both the STN and STR showed markedly weaker structural connections to areas assumed to be essential for action inhibition such as the inferior frontal cortex pars opercularis. Additionally, the cortical connectivity fingerprint of the STN and STR indicated relatively strong connections to areas related to voluntary motor initiation such as the cingulate motor area and supplementary motor area. Overall the results indicated that the cortical–STN connections were sparser compared to the STR. There were two notable exceptions, namely for the orbitofrontal cortex and ventral medial prefrontal cortex, where a higher tract strength was found for the STN. These two areas are thought to be involved in reward processing and action bias. |
| first_indexed | 2024-04-13T22:41:20Z |
| format | Article |
| id | doaj.art-d47c380a13434321bea6723a2603fda0 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-04-13T22:41:20Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-d47c380a13434321bea6723a2603fda02022-12-22T02:26:36ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292018-07-011210.3389/fnana.2018.00060370378The Connectivity Fingerprint of the Human Frontal Cortex, Subthalamic Nucleus, and StriatumBethany R. Isaacs0Bethany R. Isaacs1Birte U. Forstmann2Yasin Temel3Yasin Temel4Max C. Keuken5Integrative Model-Based Cognitive Neuroscience Research Unit, University of Amsterdam, Amsterdam, NetherlandsDepartment of Neurosurgery, Maastricht University Medical Center, Maastricht, NetherlandsIntegrative Model-Based Cognitive Neuroscience Research Unit, University of Amsterdam, Amsterdam, NetherlandsDepartment of Neurosurgery, Maastricht University Medical Center, Maastricht, NetherlandsDepartment of Neuroscience, School for Mental Health and Neuroscience, Maastricht University, Maastricht, NetherlandsIntegrative Model-Based Cognitive Neuroscience Research Unit, University of Amsterdam, Amsterdam, NetherlandsWithin the cortico basal ganglia (BG)–thalamic network, the direct and indirect pathways comprise of projections from the cortex to the striatum (STR), whereas the hyperdirect pathway(s) consist of cortical projections toward the subthalamic nucleus (STN). Each pathway possesses a functionally distinct role for action selection. The current study quantified and compared the structural connectivity between 17 distinct cortical areas with the STN and STR using 7 Tesla diffusion weighted magnetic resonance imaging (dMRI) and resting-state functional MRI (rs-fMRI) in healthy young subjects. The selection of these cortical areas was based on a literature search focusing on animal tracer studies. The results indicate that, relative to other cortical areas, both the STN and STR showed markedly weaker structural connections to areas assumed to be essential for action inhibition such as the inferior frontal cortex pars opercularis. Additionally, the cortical connectivity fingerprint of the STN and STR indicated relatively strong connections to areas related to voluntary motor initiation such as the cingulate motor area and supplementary motor area. Overall the results indicated that the cortical–STN connections were sparser compared to the STR. There were two notable exceptions, namely for the orbitofrontal cortex and ventral medial prefrontal cortex, where a higher tract strength was found for the STN. These two areas are thought to be involved in reward processing and action bias.https://www.frontiersin.org/article/10.3389/fnana.2018.00060/full7T MRIbasal gangliaconnectivityDWIRS-fMRI |
| spellingShingle | Bethany R. Isaacs Bethany R. Isaacs Birte U. Forstmann Yasin Temel Yasin Temel Max C. Keuken The Connectivity Fingerprint of the Human Frontal Cortex, Subthalamic Nucleus, and Striatum Frontiers in Neuroanatomy 7T MRI basal ganglia connectivity DWI RS-fMRI |
| title | The Connectivity Fingerprint of the Human Frontal Cortex, Subthalamic Nucleus, and Striatum |
| title_full | The Connectivity Fingerprint of the Human Frontal Cortex, Subthalamic Nucleus, and Striatum |
| title_fullStr | The Connectivity Fingerprint of the Human Frontal Cortex, Subthalamic Nucleus, and Striatum |
| title_full_unstemmed | The Connectivity Fingerprint of the Human Frontal Cortex, Subthalamic Nucleus, and Striatum |
| title_short | The Connectivity Fingerprint of the Human Frontal Cortex, Subthalamic Nucleus, and Striatum |
| title_sort | connectivity fingerprint of the human frontal cortex subthalamic nucleus and striatum |
| topic | 7T MRI basal ganglia connectivity DWI RS-fMRI |
| url | https://www.frontiersin.org/article/10.3389/fnana.2018.00060/full |
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