Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited
Development of processes using green solvents as supercritical fluids (SCFs) depends on the accuracy of modeling and predicting phase equilibrium which is of considerable importance to exploit the use of SCF process at the level of pharmaceutical industries. Solid-Fluid equilibrium modeling is assoc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/12/1448 |
| _version_ | 1797506896923459584 |
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| author | Loubna Nasri |
| author_facet | Loubna Nasri |
| author_sort | Loubna Nasri |
| collection | DOAJ |
| description | Development of processes using green solvents as supercritical fluids (SCFs) depends on the accuracy of modeling and predicting phase equilibrium which is of considerable importance to exploit the use of SCF process at the level of pharmaceutical industries. Solid-Fluid equilibrium modeling is associated to many drawbacks when compressed gas-based models as cubic equations of states (cEoSs) are used. The unavailability of experimental values of solute’s sublimation pressure presents one of the major obstacles to the solubility modeling with this type of models, and thus, its estimation is essential and inevitable. This work is an attempt to address a question regarding “accurate estimated value” of sublimation pressure of two antibiotics <i>Penicillin G</i> (benzyl penicillin) and <i>Penicillin V</i> (phenoxymethyl penicillin). Toward that, first, cEoSs are provided as the thermodynamics modeling framework and fundamental approach. Second, a discussion and a review of some literature results are given. Third, results are invoked to present a criticism analysis that comes from the use of modified form of Peng-Robinson (PR) equation of states. Finally, considerable improvement of modeling results by using a new sublimation pressure is shown. |
| first_indexed | 2024-03-10T04:40:00Z |
| format | Article |
| id | doaj.art-d47c758176c6422e87e8511c2e9bd359 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T04:40:00Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-d47c758176c6422e87e8511c2e9bd3592023-11-23T03:29:59ZengMDPI AGAntibiotics2079-63822021-11-011012144810.3390/antibiotics10121448Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States RevisitedLoubna Nasri0Department of Pharmaceutical Engineering, Faculty of Process Engineering, University Constantine 3-Salah Boubnider, Constantine 25000, AlgeriaDevelopment of processes using green solvents as supercritical fluids (SCFs) depends on the accuracy of modeling and predicting phase equilibrium which is of considerable importance to exploit the use of SCF process at the level of pharmaceutical industries. Solid-Fluid equilibrium modeling is associated to many drawbacks when compressed gas-based models as cubic equations of states (cEoSs) are used. The unavailability of experimental values of solute’s sublimation pressure presents one of the major obstacles to the solubility modeling with this type of models, and thus, its estimation is essential and inevitable. This work is an attempt to address a question regarding “accurate estimated value” of sublimation pressure of two antibiotics <i>Penicillin G</i> (benzyl penicillin) and <i>Penicillin V</i> (phenoxymethyl penicillin). Toward that, first, cEoSs are provided as the thermodynamics modeling framework and fundamental approach. Second, a discussion and a review of some literature results are given. Third, results are invoked to present a criticism analysis that comes from the use of modified form of Peng-Robinson (PR) equation of states. Finally, considerable improvement of modeling results by using a new sublimation pressure is shown.https://www.mdpi.com/2079-6382/10/12/1448supercritical CO<sub>2</sub><i>Penicillin G</i><i>Penicillin V</i>solubility modelingsublimation pressureequations of state |
| spellingShingle | Loubna Nasri Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited Antibiotics supercritical CO<sub>2</sub> <i>Penicillin G</i> <i>Penicillin V</i> solubility modeling sublimation pressure equations of state |
| title | Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited |
| title_full | Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited |
| title_fullStr | Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited |
| title_full_unstemmed | Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited |
| title_short | Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited |
| title_sort | penicillins solubility in supercritical carbon dioxide modeling by cubic equations of states revisited |
| topic | supercritical CO<sub>2</sub> <i>Penicillin G</i> <i>Penicillin V</i> solubility modeling sublimation pressure equations of state |
| url | https://www.mdpi.com/2079-6382/10/12/1448 |
| work_keys_str_mv | AT loubnanasri penicillinssolubilityinsupercriticalcarbondioxidemodelingbycubicequationsofstatesrevisited |