CD73 Overexpression Promotes Progression and Recurrence of Papillary Thyroid Carcinoma
CD73 is involved in tumor immune escape and promotes the growth and progression of cancer cells. The functional role of CD73 expression in papillary thyroid carcinoma (PTC) has not yet been established. In 511 patients with PTC, immunohistochemistry for CD73 on tissue microarrays showed that the hig...
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MDPI AG
2020-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/10/3042 |
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| author | Young Mun Jeong Haejin Cho Tae-Min Kim Yourha Kim Sora Jeon Andrey Bychkov Chan Kwon Jung |
| author_facet | Young Mun Jeong Haejin Cho Tae-Min Kim Yourha Kim Sora Jeon Andrey Bychkov Chan Kwon Jung |
| author_sort | Young Mun Jeong |
| collection | DOAJ |
| description | CD73 is involved in tumor immune escape and promotes the growth and progression of cancer cells. The functional role of CD73 expression in papillary thyroid carcinoma (PTC) has not yet been established. In 511 patients with PTC, immunohistochemistry for CD73 on tissue microarrays showed that the high expression of CD73 was associated with an aggressive histologic variant (<i>p</i> = 0.002), extrathyroidal extension (<i>p</i> < 0.001), lymph node metastasis (<i>p</i> < 0.001), and <i>BRAF</i><sup>V600E</sup> mutation (<i>p</i> = 0.015). Survival analysis results showed that patients with high CD73 expression had worse recurrence-free survival (<i>p</i> = 0.023). CD73 inhibitors induced G1 cell cycle arrest and apoptosis, inhibited the migration and invasion of PTC cells, and suppressed tumor growth in PTC xenograft nude mice. High expression of CD73 (<i>NT5E</i>) mRNA was associated with unfavorable clinicopathologic characteristics, the abundance of Tregs and dendritic cells, depletion of natural killer (NK) cells, and high expression of immune checkpoint genes and epithelial-to-mesenchymal transition-related genes in The Cancer Genome Atlas (TCGA) dataset. Taken together, CD73 expression promotes tumor progression and predicts low recurrence-free survival. Targeting the CD73–adenosine axis in the tumor microenvironment offers an attractive pathway for therapeutic strategies aimed at advanced PTC. |
| first_indexed | 2024-03-10T15:30:57Z |
| format | Article |
| id | doaj.art-d47dc493963e4fe099ee2030ca0a0e23 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T15:30:57Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d47dc493963e4fe099ee2030ca0a0e232023-11-20T17:41:32ZengMDPI AGCancers2072-66942020-10-011210304210.3390/cancers12103042CD73 Overexpression Promotes Progression and Recurrence of Papillary Thyroid CarcinomaYoung Mun Jeong0Haejin Cho1Tae-Min Kim2Yourha Kim3Sora Jeon4Andrey Bychkov5Chan Kwon Jung6Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaCancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaCancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Pathology, Kameda Medical Center, Kamogawa, Chiba 296-8602, JapanDepartment of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaCD73 is involved in tumor immune escape and promotes the growth and progression of cancer cells. The functional role of CD73 expression in papillary thyroid carcinoma (PTC) has not yet been established. In 511 patients with PTC, immunohistochemistry for CD73 on tissue microarrays showed that the high expression of CD73 was associated with an aggressive histologic variant (<i>p</i> = 0.002), extrathyroidal extension (<i>p</i> < 0.001), lymph node metastasis (<i>p</i> < 0.001), and <i>BRAF</i><sup>V600E</sup> mutation (<i>p</i> = 0.015). Survival analysis results showed that patients with high CD73 expression had worse recurrence-free survival (<i>p</i> = 0.023). CD73 inhibitors induced G1 cell cycle arrest and apoptosis, inhibited the migration and invasion of PTC cells, and suppressed tumor growth in PTC xenograft nude mice. High expression of CD73 (<i>NT5E</i>) mRNA was associated with unfavorable clinicopathologic characteristics, the abundance of Tregs and dendritic cells, depletion of natural killer (NK) cells, and high expression of immune checkpoint genes and epithelial-to-mesenchymal transition-related genes in The Cancer Genome Atlas (TCGA) dataset. Taken together, CD73 expression promotes tumor progression and predicts low recurrence-free survival. Targeting the CD73–adenosine axis in the tumor microenvironment offers an attractive pathway for therapeutic strategies aimed at advanced PTC.https://www.mdpi.com/2072-6694/12/10/3042thyroid cancerCD735′-Nucleotidasetumor microenvironmentepithelial–mesenchymal transition |
| spellingShingle | Young Mun Jeong Haejin Cho Tae-Min Kim Yourha Kim Sora Jeon Andrey Bychkov Chan Kwon Jung CD73 Overexpression Promotes Progression and Recurrence of Papillary Thyroid Carcinoma Cancers thyroid cancer CD73 5′-Nucleotidase tumor microenvironment epithelial–mesenchymal transition |
| title | CD73 Overexpression Promotes Progression and Recurrence of Papillary Thyroid Carcinoma |
| title_full | CD73 Overexpression Promotes Progression and Recurrence of Papillary Thyroid Carcinoma |
| title_fullStr | CD73 Overexpression Promotes Progression and Recurrence of Papillary Thyroid Carcinoma |
| title_full_unstemmed | CD73 Overexpression Promotes Progression and Recurrence of Papillary Thyroid Carcinoma |
| title_short | CD73 Overexpression Promotes Progression and Recurrence of Papillary Thyroid Carcinoma |
| title_sort | cd73 overexpression promotes progression and recurrence of papillary thyroid carcinoma |
| topic | thyroid cancer CD73 5′-Nucleotidase tumor microenvironment epithelial–mesenchymal transition |
| url | https://www.mdpi.com/2072-6694/12/10/3042 |
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