Conservative treatment of cervical cancer: A single center experience over a two-decade period
Objective: To report the surgical, oncological, and obstetrical outcomes of the different surgical techniques used for the fertility-sparing treatment of patients with early-stage cervical cancer. Methods: We retrospectively analyzed all fertility-sparing procedures performed between 2004 and 2020....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Gynecologic Oncology Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578923000954 |
| _version_ | 1797753986326986752 |
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| author | Guido M. Rey Valzacchi Diego Odetto José M. Saadi Liliana B. Zamora Candela Loza Milagros Medina Myriam B. Perrotta |
| author_facet | Guido M. Rey Valzacchi Diego Odetto José M. Saadi Liliana B. Zamora Candela Loza Milagros Medina Myriam B. Perrotta |
| author_sort | Guido M. Rey Valzacchi |
| collection | DOAJ |
| description | Objective: To report the surgical, oncological, and obstetrical outcomes of the different surgical techniques used for the fertility-sparing treatment of patients with early-stage cervical cancer. Methods: We retrospectively analyzed all fertility-sparing procedures performed between 2004 and 2020. The study included patients desiring to preserve fertility who had squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma histology, all grades, and FIGO 2009 stage IA2-IB1 tumors. Results: 48 patients met the inclusion criteria. Eight patients (16.7%) had stage IA2, and 40 (83.3%) had stage IB1 tumors. Conization with pelvic lymph node assessment was performed in 5 (10.4%) patients, an open radical trachelectomy in 21 (43.8%), and a laparoscopic radical trachelectomy in 22 (45.8%). No major intraoperative complications were registered. Two patients required surgery due to an early postoperative complication. Late postoperative complications were seen in 15 patients (31.2%), with cervical stenosis being the most frequent (60%). The rate of DFS at 2 and 5 years was 89% (95% CI, 76–95%), and the 5- year OS was 96% (95% CI, 83–98%). Univariate analysis demonstrated a relationship between tumor size and recurrence, but not for other prognostic tumor factors or surgical approach. One patient (4.8%) developed recurrent disease in the open radical trachelectomy group, and five (22.7%) in the laparoscopic radical trachelectomy group. The pregnancy rate was 41.4%, and the live birth rate 88.2%. Conclusion: Fertility-sparing treatment for patients with early-stage cervical cancer is ever-evolving. This study adds information to the literature about the outcomes of these quite uncommon procedures, and allows a critical analysis of many of the topics which are under discussion. |
| first_indexed | 2024-03-12T17:26:57Z |
| format | Article |
| id | doaj.art-d47e49030e604209a64fc2d8aeecd2d9 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-03-12T17:26:57Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-d47e49030e604209a64fc2d8aeecd2d92023-08-05T05:16:12ZengElsevierGynecologic Oncology Reports2352-57892023-08-0148101226Conservative treatment of cervical cancer: A single center experience over a two-decade periodGuido M. Rey Valzacchi0Diego Odetto1José M. Saadi2Liliana B. Zamora3Candela Loza4Milagros Medina5Myriam B. Perrotta6Corresponding author at: Department of Gynecology, Hospital Italiano of Buenos Aires, Potosi 4135, Zip Code 1199, Buenos Aires, Argentina.; Division of Gynecologic Oncology, Hospital Italiano of Buenos Aires, Buenos Aires, ArgentinaDivision of Gynecologic Oncology, Hospital Italiano of Buenos Aires, Buenos Aires, ArgentinaDivision of Gynecologic Oncology, Hospital Italiano of Buenos Aires, Buenos Aires, ArgentinaDivision of Gynecologic Oncology, Hospital Italiano of Buenos Aires, Buenos Aires, ArgentinaDivision of Gynecologic Oncology, Hospital Italiano of Buenos Aires, Buenos Aires, ArgentinaDivision of Gynecologic Oncology, Hospital Italiano of Buenos Aires, Buenos Aires, ArgentinaDivision of Gynecologic Oncology, Hospital Italiano of Buenos Aires, Buenos Aires, ArgentinaObjective: To report the surgical, oncological, and obstetrical outcomes of the different surgical techniques used for the fertility-sparing treatment of patients with early-stage cervical cancer. Methods: We retrospectively analyzed all fertility-sparing procedures performed between 2004 and 2020. The study included patients desiring to preserve fertility who had squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma histology, all grades, and FIGO 2009 stage IA2-IB1 tumors. Results: 48 patients met the inclusion criteria. Eight patients (16.7%) had stage IA2, and 40 (83.3%) had stage IB1 tumors. Conization with pelvic lymph node assessment was performed in 5 (10.4%) patients, an open radical trachelectomy in 21 (43.8%), and a laparoscopic radical trachelectomy in 22 (45.8%). No major intraoperative complications were registered. Two patients required surgery due to an early postoperative complication. Late postoperative complications were seen in 15 patients (31.2%), with cervical stenosis being the most frequent (60%). The rate of DFS at 2 and 5 years was 89% (95% CI, 76–95%), and the 5- year OS was 96% (95% CI, 83–98%). Univariate analysis demonstrated a relationship between tumor size and recurrence, but not for other prognostic tumor factors or surgical approach. One patient (4.8%) developed recurrent disease in the open radical trachelectomy group, and five (22.7%) in the laparoscopic radical trachelectomy group. The pregnancy rate was 41.4%, and the live birth rate 88.2%. Conclusion: Fertility-sparing treatment for patients with early-stage cervical cancer is ever-evolving. This study adds information to the literature about the outcomes of these quite uncommon procedures, and allows a critical analysis of many of the topics which are under discussion.http://www.sciencedirect.com/science/article/pii/S2352578923000954 |
| spellingShingle | Guido M. Rey Valzacchi Diego Odetto José M. Saadi Liliana B. Zamora Candela Loza Milagros Medina Myriam B. Perrotta Conservative treatment of cervical cancer: A single center experience over a two-decade period Gynecologic Oncology Reports |
| title | Conservative treatment of cervical cancer: A single center experience over a two-decade period |
| title_full | Conservative treatment of cervical cancer: A single center experience over a two-decade period |
| title_fullStr | Conservative treatment of cervical cancer: A single center experience over a two-decade period |
| title_full_unstemmed | Conservative treatment of cervical cancer: A single center experience over a two-decade period |
| title_short | Conservative treatment of cervical cancer: A single center experience over a two-decade period |
| title_sort | conservative treatment of cervical cancer a single center experience over a two decade period |
| url | http://www.sciencedirect.com/science/article/pii/S2352578923000954 |
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