Early knee osteoarthritis management should first address mechanical joint overload
Early knee osteoarthritis poses a therapeutic dilemma to the musculoskeletal clinician. Despite the recent interest in arthroscopic and injectable regenerative therapies intended to repair or restore a focal target such as cartilage, meniscus, or subchondral bone, none have been shown to slow diseas...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Open Medical Publishing
2014-03-01
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| Series: | Orthopedic Reviews |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/or/article/view/5188 |
| _version_ | 1818943353421561856 |
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| author | Elizabeth A. Arendt Larry E. Miller Jon E. Block |
| author_facet | Elizabeth A. Arendt Larry E. Miller Jon E. Block |
| author_sort | Elizabeth A. Arendt |
| collection | DOAJ |
| description | Early knee osteoarthritis poses a therapeutic dilemma to the musculoskeletal clinician. Despite the recent interest in arthroscopic and injectable regenerative therapies intended to repair or restore a focal target such as cartilage, meniscus, or subchondral bone, none have been shown to slow disease progression. A likely cause of these disappointing treatment outcomes is the failure to address chronic and excessive loading of the knee joint. A growing body of evidence suggests that first-line therapies for early knee osteoarthritis should emphasize unloading the knee joint since any potential therapeutic benefit of regenerative therapies will likely be attenuated by excessive mechanical demand at the knee joint. Minimally invasive medical devices such as patient-specific interpositional implants and extracapsular joint unloading implants are currently in development to address this clinical need. |
| first_indexed | 2024-12-20T07:25:59Z |
| format | Article |
| id | doaj.art-d48141b45fd14b788fd87a9ed252892f |
| institution | Directory Open Access Journal |
| issn | 2035-8237 2035-8164 |
| language | English |
| last_indexed | 2024-12-20T07:25:59Z |
| publishDate | 2014-03-01 |
| publisher | Open Medical Publishing |
| record_format | Article |
| series | Orthopedic Reviews |
| spelling | doaj.art-d48141b45fd14b788fd87a9ed252892f2022-12-21T19:48:33ZengOpen Medical PublishingOrthopedic Reviews2035-82372035-81642014-03-016110.4081/or.2014.51882753Early knee osteoarthritis management should first address mechanical joint overloadElizabeth A. Arendt0Larry E. Miller1Jon E. Block2Department of Orthopedic Surgery, University of Minnesota, Minneapolis, MNMiller Scientific Consulting Inc., Asheville, NC; The Jon Block Group, San Francisco, CAThe Jon Block Group, San Francisco, CAEarly knee osteoarthritis poses a therapeutic dilemma to the musculoskeletal clinician. Despite the recent interest in arthroscopic and injectable regenerative therapies intended to repair or restore a focal target such as cartilage, meniscus, or subchondral bone, none have been shown to slow disease progression. A likely cause of these disappointing treatment outcomes is the failure to address chronic and excessive loading of the knee joint. A growing body of evidence suggests that first-line therapies for early knee osteoarthritis should emphasize unloading the knee joint since any potential therapeutic benefit of regenerative therapies will likely be attenuated by excessive mechanical demand at the knee joint. Minimally invasive medical devices such as patient-specific interpositional implants and extracapsular joint unloading implants are currently in development to address this clinical need.http://www.pagepress.org/journals/index.php/or/article/view/5188joint loading, knee, osteoarthritis |
| spellingShingle | Elizabeth A. Arendt Larry E. Miller Jon E. Block Early knee osteoarthritis management should first address mechanical joint overload Orthopedic Reviews joint loading, knee, osteoarthritis |
| title | Early knee osteoarthritis management should first address mechanical joint overload |
| title_full | Early knee osteoarthritis management should first address mechanical joint overload |
| title_fullStr | Early knee osteoarthritis management should first address mechanical joint overload |
| title_full_unstemmed | Early knee osteoarthritis management should first address mechanical joint overload |
| title_short | Early knee osteoarthritis management should first address mechanical joint overload |
| title_sort | early knee osteoarthritis management should first address mechanical joint overload |
| topic | joint loading, knee, osteoarthritis |
| url | http://www.pagepress.org/journals/index.php/or/article/view/5188 |
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