Sinus Mucosa Thinning and Perforations after Sinus Lifting Performed with Different Xenografts: A Histological Analysis in Rabbits
Background: Experimental studies have shown a progressive thinning and perforations of the sinus mucosa associated with sharpened edges and the cutting projections of graft particles used simultaneously for maxillary sinus augmentation. Hence, the aim of the present study was to evaluate the damagin...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Dentistry Journal |
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| Online Access: | https://www.mdpi.com/2304-6767/10/1/2 |
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| author | Riccardo Favero Karol Alí Apaza Alccayhuaman Daniele Botticelli Samuel Porfirio Xavier Vitor Ferreira Balan Veronica Macchi Raffaele De Caro |
| author_facet | Riccardo Favero Karol Alí Apaza Alccayhuaman Daniele Botticelli Samuel Porfirio Xavier Vitor Ferreira Balan Veronica Macchi Raffaele De Caro |
| author_sort | Riccardo Favero |
| collection | DOAJ |
| description | Background: Experimental studies have shown a progressive thinning and perforations of the sinus mucosa associated with sharpened edges and the cutting projections of graft particles used simultaneously for maxillary sinus augmentation. Hence, the aim of the present study was to evaluate the damaging effects of two different bovine grafts on the sinus mucosa after sinus augmentation. Methods: Twenty New Zealand rabbits received a bilateral sinus lifting using, as fillers, two different types of deproteinized bovine bone in granules, one processed at low temperature (low-T group), and the other at high temperature (high-T group). Thinned mucosa sites (<40 µm) and perforations were evaluated in the sinus mucosa that were in contact with graft granules after 2 and 10 weeks, in ten animals per period. Results: After 2 weeks of healing, the number of thinned mucosa sites was 118 in the low-T group, and 149 in the high-T group (<i>p</i> = 0.191). At the 10-week assessment, the thinned sites increased to 237 and 195 sites, respectively. The numbers of sinus mucosa perforations after 2 weeks were eight and three in the low-T and high-T group, respectively. At the 10-week evaluation, the perforations increased to 19 in the low-T group, and to 14 in the high-T group. Conclusions: The contact with bovine xenografts yielded thinning and perforations of the sinus mucosa. Despite the differences in characteristics and dimensions, no differences were found between the two xenografts in the numbers of thinning mucosa sites and perforations. However, a trend of more events was found in the low-T compared to the high-T group. |
| first_indexed | 2024-03-10T01:39:46Z |
| format | Article |
| id | doaj.art-d484db8dd6e84788ac8c81192d9e72c3 |
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| issn | 2304-6767 |
| language | English |
| last_indexed | 2024-03-10T01:39:46Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj.art-d484db8dd6e84788ac8c81192d9e72c32023-11-23T13:26:22ZengMDPI AGDentistry Journal2304-67672021-12-01101210.3390/dj10010002Sinus Mucosa Thinning and Perforations after Sinus Lifting Performed with Different Xenografts: A Histological Analysis in RabbitsRiccardo Favero0Karol Alí Apaza Alccayhuaman1Daniele Botticelli2Samuel Porfirio Xavier3Vitor Ferreira Balan4Veronica Macchi5Raffaele De Caro6Dipartimento di Neuroscienze, Università di Padova, 35128 Padova, ItalyDepartment of Oral Biology, Medical University of Vienna, 1090 Vienna, AustriaARDEC Academy, 47923 Rimini, ItalyDepartment of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 14040-904, BrazilDepartment of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 14040-904, BrazilDipartimento di Neuroscienze, Università di Padova, 35128 Padova, ItalyDipartimento di Neuroscienze, Università di Padova, 35128 Padova, ItalyBackground: Experimental studies have shown a progressive thinning and perforations of the sinus mucosa associated with sharpened edges and the cutting projections of graft particles used simultaneously for maxillary sinus augmentation. Hence, the aim of the present study was to evaluate the damaging effects of two different bovine grafts on the sinus mucosa after sinus augmentation. Methods: Twenty New Zealand rabbits received a bilateral sinus lifting using, as fillers, two different types of deproteinized bovine bone in granules, one processed at low temperature (low-T group), and the other at high temperature (high-T group). Thinned mucosa sites (<40 µm) and perforations were evaluated in the sinus mucosa that were in contact with graft granules after 2 and 10 weeks, in ten animals per period. Results: After 2 weeks of healing, the number of thinned mucosa sites was 118 in the low-T group, and 149 in the high-T group (<i>p</i> = 0.191). At the 10-week assessment, the thinned sites increased to 237 and 195 sites, respectively. The numbers of sinus mucosa perforations after 2 weeks were eight and three in the low-T and high-T group, respectively. At the 10-week evaluation, the perforations increased to 19 in the low-T group, and to 14 in the high-T group. Conclusions: The contact with bovine xenografts yielded thinning and perforations of the sinus mucosa. Despite the differences in characteristics and dimensions, no differences were found between the two xenografts in the numbers of thinning mucosa sites and perforations. However, a trend of more events was found in the low-T compared to the high-T group.https://www.mdpi.com/2304-6767/10/1/2animal studysinus floor elevationbone healingSchneiderian membranehistology |
| spellingShingle | Riccardo Favero Karol Alí Apaza Alccayhuaman Daniele Botticelli Samuel Porfirio Xavier Vitor Ferreira Balan Veronica Macchi Raffaele De Caro Sinus Mucosa Thinning and Perforations after Sinus Lifting Performed with Different Xenografts: A Histological Analysis in Rabbits Dentistry Journal animal study sinus floor elevation bone healing Schneiderian membrane histology |
| title | Sinus Mucosa Thinning and Perforations after Sinus Lifting Performed with Different Xenografts: A Histological Analysis in Rabbits |
| title_full | Sinus Mucosa Thinning and Perforations after Sinus Lifting Performed with Different Xenografts: A Histological Analysis in Rabbits |
| title_fullStr | Sinus Mucosa Thinning and Perforations after Sinus Lifting Performed with Different Xenografts: A Histological Analysis in Rabbits |
| title_full_unstemmed | Sinus Mucosa Thinning and Perforations after Sinus Lifting Performed with Different Xenografts: A Histological Analysis in Rabbits |
| title_short | Sinus Mucosa Thinning and Perforations after Sinus Lifting Performed with Different Xenografts: A Histological Analysis in Rabbits |
| title_sort | sinus mucosa thinning and perforations after sinus lifting performed with different xenografts a histological analysis in rabbits |
| topic | animal study sinus floor elevation bone healing Schneiderian membrane histology |
| url | https://www.mdpi.com/2304-6767/10/1/2 |
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