Diagnostic Value of <sup>18</sup>F-FDG-PET/CT in Patients with FUO
Conventional diagnostic imaging is often ineffective in revealing the underlying cause in a considerable proportion of patients with fever of unknown origin (FUO). The aim of this study was to assess the diagnostic value of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomogra...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/7/2112 |
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| author | Stamata Georga Paraskevi Exadaktylou Ioannis Petrou Dimitrios Katsampoukas Vasilios Mpalaris Efstratios-Iordanis Moralidis Kostoula Arvaniti Christos Papastergiou Georgios Arsos |
| author_facet | Stamata Georga Paraskevi Exadaktylou Ioannis Petrou Dimitrios Katsampoukas Vasilios Mpalaris Efstratios-Iordanis Moralidis Kostoula Arvaniti Christos Papastergiou Georgios Arsos |
| author_sort | Stamata Georga |
| collection | DOAJ |
| description | Conventional diagnostic imaging is often ineffective in revealing the underlying cause in a considerable proportion of patients with fever of unknown origin (FUO). The aim of this study was to assess the diagnostic value of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG-PET/CT) in patients with FUO. We retrospectively reviewed <sup>18</sup>F-FDG-PET/CT scans performed on 50 consecutive adult patients referred to our department for further investigation of classic FUO. Final diagnosis was based on histopathological and microbiological findings, clinical criteria, or clinical follow-up. Final diagnosis was established in 39/50 (78%) of the patients. The cause of FUO was infection in 20/50 (40%), noninfectious inflammatory diseases in 11/50 (22%), and malignancy in 8/50 (16%) patients. Fever remained unexplained in 11/50 (22%) patients. <sup>18</sup>F-FDG-PET/CT scan substantially contributed to the diagnosis in 70% of the patients, either by identifying the underlying cause of FUO or by directing to the most appropriate site for biopsy. Sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of <sup>18</sup>F-FDG-PET/CT for active disease detection in patients with FUO were 94.7%, 50.0%, 84.0%, 85.7%, and 75.0%, respectively. In conclusion, whole-body <sup>18</sup>F-FDG-PET/CT is a highly sensitive method for detection of the underlining cause of FUO or for correctly targeting suspicious lesions for further evaluation. |
| first_indexed | 2024-03-10T18:40:59Z |
| format | Article |
| id | doaj.art-d484e21cf8c64b6e82ad9c1ec8a55d38 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T18:40:59Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-d484e21cf8c64b6e82ad9c1ec8a55d382023-11-20T05:52:35ZengMDPI AGJournal of Clinical Medicine2077-03832020-07-0197211210.3390/jcm9072112Diagnostic Value of <sup>18</sup>F-FDG-PET/CT in Patients with FUOStamata Georga0Paraskevi Exadaktylou1Ioannis Petrou2Dimitrios Katsampoukas3Vasilios Mpalaris4Efstratios-Iordanis Moralidis5Kostoula Arvaniti6Christos Papastergiou7Georgios Arsos83rd Department of Nuclear Medicine, Aristotle University of Thessaloniki Medical School, Papageorgiou General Hospital, 56403 Thessaloniki, Greece3rd Department of Nuclear Medicine, Aristotle University of Thessaloniki Medical School, Papageorgiou General Hospital, 56403 Thessaloniki, Greece3rd Department of Nuclear Medicine, Aristotle University of Thessaloniki Medical School, Papageorgiou General Hospital, 56403 Thessaloniki, Greece3rd Department of Nuclear Medicine, Aristotle University of Thessaloniki Medical School, Papageorgiou General Hospital, 56403 Thessaloniki, Greece3rd Department of Nuclear Medicine, Aristotle University of Thessaloniki Medical School, Papageorgiou General Hospital, 56403 Thessaloniki, Greece3rd Department of Nuclear Medicine, Aristotle University of Thessaloniki Medical School, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceICU and Antimicrobial Stewardship Unit, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceDepartment of Radiology, Papageorgiou General Hospital, 56403 Thessaloniki, Greece3rd Department of Nuclear Medicine, Aristotle University of Thessaloniki Medical School, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceConventional diagnostic imaging is often ineffective in revealing the underlying cause in a considerable proportion of patients with fever of unknown origin (FUO). The aim of this study was to assess the diagnostic value of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG-PET/CT) in patients with FUO. We retrospectively reviewed <sup>18</sup>F-FDG-PET/CT scans performed on 50 consecutive adult patients referred to our department for further investigation of classic FUO. Final diagnosis was based on histopathological and microbiological findings, clinical criteria, or clinical follow-up. Final diagnosis was established in 39/50 (78%) of the patients. The cause of FUO was infection in 20/50 (40%), noninfectious inflammatory diseases in 11/50 (22%), and malignancy in 8/50 (16%) patients. Fever remained unexplained in 11/50 (22%) patients. <sup>18</sup>F-FDG-PET/CT scan substantially contributed to the diagnosis in 70% of the patients, either by identifying the underlying cause of FUO or by directing to the most appropriate site for biopsy. Sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of <sup>18</sup>F-FDG-PET/CT for active disease detection in patients with FUO were 94.7%, 50.0%, 84.0%, 85.7%, and 75.0%, respectively. In conclusion, whole-body <sup>18</sup>F-FDG-PET/CT is a highly sensitive method for detection of the underlining cause of FUO or for correctly targeting suspicious lesions for further evaluation.https://www.mdpi.com/2077-0383/9/7/2112fever of unknown originFUOPET/CT<sup>18</sup>F-FDG-PET/CT |
| spellingShingle | Stamata Georga Paraskevi Exadaktylou Ioannis Petrou Dimitrios Katsampoukas Vasilios Mpalaris Efstratios-Iordanis Moralidis Kostoula Arvaniti Christos Papastergiou Georgios Arsos Diagnostic Value of <sup>18</sup>F-FDG-PET/CT in Patients with FUO Journal of Clinical Medicine fever of unknown origin FUO PET/CT <sup>18</sup>F-FDG-PET/CT |
| title | Diagnostic Value of <sup>18</sup>F-FDG-PET/CT in Patients with FUO |
| title_full | Diagnostic Value of <sup>18</sup>F-FDG-PET/CT in Patients with FUO |
| title_fullStr | Diagnostic Value of <sup>18</sup>F-FDG-PET/CT in Patients with FUO |
| title_full_unstemmed | Diagnostic Value of <sup>18</sup>F-FDG-PET/CT in Patients with FUO |
| title_short | Diagnostic Value of <sup>18</sup>F-FDG-PET/CT in Patients with FUO |
| title_sort | diagnostic value of sup 18 sup f fdg pet ct in patients with fuo |
| topic | fever of unknown origin FUO PET/CT <sup>18</sup>F-FDG-PET/CT |
| url | https://www.mdpi.com/2077-0383/9/7/2112 |
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