Would <i>Zika virus</i> Infection in Pregnancy Be a Sentence of Poor Neurological Prognosis for Exposed Children? Neurodevelopmental Outcomes in a Cohort from Brazilian Amazon
Infections with Flavivirus in pregnant women are not associated with vertical transmission. However, in 2015, severe cases of congenital infection were reported during the <i>Zika virus</i> outbreak in Brazil. More subtle infections in children born to mothers with ZIKV still remain unce...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/12/2659 |
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| author | Marília Rosa Abtibol-Bernardino Lucíola de Fátima Albuquerque de Almeida Peixoto Marcia da Costa Castilho Camila Helena Aguiar Bôtto-Menezes Silvana Gomes Benzecry Rodrigo Haruo Otani Gabriela Ribeiro Ivo Rodrigues Beatriz Caroline Soares Chaves Geruza Alfaia de Oliveira Cristina de Souza Rodrigues Flor Ernestina Martinez-Espinosa Maria das Graças Costa Alecrim |
| author_facet | Marília Rosa Abtibol-Bernardino Lucíola de Fátima Albuquerque de Almeida Peixoto Marcia da Costa Castilho Camila Helena Aguiar Bôtto-Menezes Silvana Gomes Benzecry Rodrigo Haruo Otani Gabriela Ribeiro Ivo Rodrigues Beatriz Caroline Soares Chaves Geruza Alfaia de Oliveira Cristina de Souza Rodrigues Flor Ernestina Martinez-Espinosa Maria das Graças Costa Alecrim |
| author_sort | Marília Rosa Abtibol-Bernardino |
| collection | DOAJ |
| description | Infections with Flavivirus in pregnant women are not associated with vertical transmission. However, in 2015, severe cases of congenital infection were reported during the <i>Zika virus</i> outbreak in Brazil. More subtle infections in children born to mothers with ZIKV still remain uncertain and the spectrum of this new congenital syndrome is still under construction. This study describes outcomes regarding neurodevelopment and neurological examination in the first years of life, of a cohort of 77 children born to pregnant women with ZIKV infection in Manaus, Brazil, from 2017 to 2020. In the group of normocephalic children (92.2%), most showed satisfactory performance in neuropsychomotor development, with a delay in 29.6% and changes in neurological examination in 27.1%, with two children showing muscle-strength deficits. All microcephalic children (5.2%) evolved with severe neuropsychomotor-development delay, spastic tetraparesis, and alterations in the imaging exam. In this cohort, 10.5% of the children had macrocephaly at birth, but only 2.6% remained in this classification. Although microcephaly has been considered as the main marker of congenital-<i>Zika-virus</i> syndrome in previous studies, its absence does not exclude the possibility of the syndrome. This highlights the importance of clinical follow-up, regardless of the classification of head circumference at birth. |
| first_indexed | 2024-03-09T15:45:11Z |
| format | Article |
| id | doaj.art-d486c143196c4bed80c2ab1b179e0aa7 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T15:45:11Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-d486c143196c4bed80c2ab1b179e0aa72023-11-24T18:37:21ZengMDPI AGViruses1999-49152022-11-011412265910.3390/v14122659Would <i>Zika virus</i> Infection in Pregnancy Be a Sentence of Poor Neurological Prognosis for Exposed Children? Neurodevelopmental Outcomes in a Cohort from Brazilian AmazonMarília Rosa Abtibol-Bernardino0Lucíola de Fátima Albuquerque de Almeida Peixoto1Marcia da Costa Castilho2Camila Helena Aguiar Bôtto-Menezes3Silvana Gomes Benzecry4Rodrigo Haruo Otani5Gabriela Ribeiro Ivo Rodrigues6Beatriz Caroline Soares Chaves7Geruza Alfaia de Oliveira8Cristina de Souza Rodrigues9Flor Ernestina Martinez-Espinosa10Maria das Graças Costa Alecrim11Postgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, BrazilPostgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, BrazilDepartment of Virology, Tropical Medicine Foundation Dr Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, BrazilPostgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, BrazilDepartment of Medicine, School of Health Sciences, State University of Amazonas (UEA), Manaus 69065-001, BrazilDepartment of Medicine, School of Health Sciences, State University of Amazonas (UEA), Manaus 69065-001, BrazilPostgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, BrazilPostgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, BrazilPostgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, BrazilPostgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, BrazilPostgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, BrazilPostgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, BrazilInfections with Flavivirus in pregnant women are not associated with vertical transmission. However, in 2015, severe cases of congenital infection were reported during the <i>Zika virus</i> outbreak in Brazil. More subtle infections in children born to mothers with ZIKV still remain uncertain and the spectrum of this new congenital syndrome is still under construction. This study describes outcomes regarding neurodevelopment and neurological examination in the first years of life, of a cohort of 77 children born to pregnant women with ZIKV infection in Manaus, Brazil, from 2017 to 2020. In the group of normocephalic children (92.2%), most showed satisfactory performance in neuropsychomotor development, with a delay in 29.6% and changes in neurological examination in 27.1%, with two children showing muscle-strength deficits. All microcephalic children (5.2%) evolved with severe neuropsychomotor-development delay, spastic tetraparesis, and alterations in the imaging exam. In this cohort, 10.5% of the children had macrocephaly at birth, but only 2.6% remained in this classification. Although microcephaly has been considered as the main marker of congenital-<i>Zika-virus</i> syndrome in previous studies, its absence does not exclude the possibility of the syndrome. This highlights the importance of clinical follow-up, regardless of the classification of head circumference at birth.https://www.mdpi.com/1999-4915/14/12/2659arbovirus<i>Zika virus</i>childrencongenital <i>Zika virus</i> syndromecoinfectionneurodevelopment |
| spellingShingle | Marília Rosa Abtibol-Bernardino Lucíola de Fátima Albuquerque de Almeida Peixoto Marcia da Costa Castilho Camila Helena Aguiar Bôtto-Menezes Silvana Gomes Benzecry Rodrigo Haruo Otani Gabriela Ribeiro Ivo Rodrigues Beatriz Caroline Soares Chaves Geruza Alfaia de Oliveira Cristina de Souza Rodrigues Flor Ernestina Martinez-Espinosa Maria das Graças Costa Alecrim Would <i>Zika virus</i> Infection in Pregnancy Be a Sentence of Poor Neurological Prognosis for Exposed Children? Neurodevelopmental Outcomes in a Cohort from Brazilian Amazon Viruses arbovirus <i>Zika virus</i> children congenital <i>Zika virus</i> syndrome coinfection neurodevelopment |
| title | Would <i>Zika virus</i> Infection in Pregnancy Be a Sentence of Poor Neurological Prognosis for Exposed Children? Neurodevelopmental Outcomes in a Cohort from Brazilian Amazon |
| title_full | Would <i>Zika virus</i> Infection in Pregnancy Be a Sentence of Poor Neurological Prognosis for Exposed Children? Neurodevelopmental Outcomes in a Cohort from Brazilian Amazon |
| title_fullStr | Would <i>Zika virus</i> Infection in Pregnancy Be a Sentence of Poor Neurological Prognosis for Exposed Children? Neurodevelopmental Outcomes in a Cohort from Brazilian Amazon |
| title_full_unstemmed | Would <i>Zika virus</i> Infection in Pregnancy Be a Sentence of Poor Neurological Prognosis for Exposed Children? Neurodevelopmental Outcomes in a Cohort from Brazilian Amazon |
| title_short | Would <i>Zika virus</i> Infection in Pregnancy Be a Sentence of Poor Neurological Prognosis for Exposed Children? Neurodevelopmental Outcomes in a Cohort from Brazilian Amazon |
| title_sort | would i zika virus i infection in pregnancy be a sentence of poor neurological prognosis for exposed children neurodevelopmental outcomes in a cohort from brazilian amazon |
| topic | arbovirus <i>Zika virus</i> children congenital <i>Zika virus</i> syndrome coinfection neurodevelopment |
| url | https://www.mdpi.com/1999-4915/14/12/2659 |
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