IGF1R is a mediator of sex-specific metabolism in mice: Effects of age and high-fat diet

IGF1R is a mediator of sex-specific metabolism in mice: Effects of age and high-fat diet

ObjectiveWe aimed to investigate the short and long-term metabolic consequences of IGF1R systemic gene deficiency in mice.MethodsUBC-CreERT2, Igf1rfl/fl mutant mice were used to suppress IGF1R signaling in adult tissues by inducing postnatal generalized Igf1r deletion with tamoxifen. Animals were an...

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Bibliographic Details
Main Authors: Patricia Pérez-Matute, Icíar P. López, María Íñiguez, Emma Recio-Fernández, Raquel Torrens, Sergio Piñeiro-Hermida, Elvira Alfaro-Arnedo, Luong Chau, Christina Walz, Andreas Hoeflich, José A. Oteo, José G. Pichel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Endocrinology
Subjects:
IGF1R
aging
insulin resistance
diet-induced obesity
fatty liver
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1033208/full

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