Clarification of the margin status by the multidisciplinary tumor board following transoral robotic surgery for p16 positive oropharyngeal squamous cell carcinoma
Abstract Objectives Margin status interpretation following transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC) is challenging. This study aims to assess the discrepancy between status of margins as reported by the pathologist versus as determined by multi‐disciplinary...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Laryngoscope Investigative Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/lio2.1163 |
| _version_ | 1797384833513553920 |
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| author | Aarthi Parvathaneni Sapna A. Patel Jeffrey J. Houlton John Pang Neal D. Futran |
| author_facet | Aarthi Parvathaneni Sapna A. Patel Jeffrey J. Houlton John Pang Neal D. Futran |
| author_sort | Aarthi Parvathaneni |
| collection | DOAJ |
| description | Abstract Objectives Margin status interpretation following transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC) is challenging. This study aims to assess the discrepancy between status of margins as reported by the pathologist versus as determined by multi‐disciplinary team review (MDTB). Methods A retrospective study of 57 patients with OPSCC who underwent TORS from January 2010 to December 2016 was conducted. Our primary outcome measure was the discrepancy between the surgical specimen margins as described in the pathology report versus final margin status that was determined after the multi‐disciplinary team discussion. Fisher's exact test was used. Results Based on the pathologist‐report, 29 subjects (51%) had positive margins, compared to 2 (4%) after multi‐disciplinary team discussion. Receipt of chemotherapy correlated with final margin status as determined by MDTB, not with initial main specimen margins (p = .02 and p = .08, respectively). With a median follow up of 28.4 months, two subjects (4%) had loco‐regional recurrence. Conclusion Following TORS, there was a significant discrepancy between status of margins as reported by the pathologist versus as determined by MDTB review. Chemotherapy was avoided in 93.1% of cases that were originally reported as positive margins by the pathologist with an acceptably low recurrence rate. Level of evidence 4. |
| first_indexed | 2024-03-08T21:45:22Z |
| format | Article |
| id | doaj.art-d489547b10ff425abed34d647380e524 |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-03-08T21:45:22Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-d489547b10ff425abed34d647380e5242023-12-20T09:48:34ZengWileyLaryngoscope Investigative Otolaryngology2378-80382023-12-01861500150610.1002/lio2.1163Clarification of the margin status by the multidisciplinary tumor board following transoral robotic surgery for p16 positive oropharyngeal squamous cell carcinomaAarthi Parvathaneni0Sapna A. Patel1Jeffrey J. Houlton2John Pang3Neal D. Futran4McGovern Medical School Houston Texas USADepartment of Otolaryngology, The Southeast Permanente Medical Group Atlanta Georgia USAHead & Neck Specialists/Sarah Cannon Cancer Institute Charleston South Carolina USADepartment of Otolaryngology—Head and Neck Surgery Ochsner LSU Health Shreveport Louisiana USADepartment of Otolaryngology—Head and Neck Surgery University of Washington Seattle Washington USAAbstract Objectives Margin status interpretation following transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC) is challenging. This study aims to assess the discrepancy between status of margins as reported by the pathologist versus as determined by multi‐disciplinary team review (MDTB). Methods A retrospective study of 57 patients with OPSCC who underwent TORS from January 2010 to December 2016 was conducted. Our primary outcome measure was the discrepancy between the surgical specimen margins as described in the pathology report versus final margin status that was determined after the multi‐disciplinary team discussion. Fisher's exact test was used. Results Based on the pathologist‐report, 29 subjects (51%) had positive margins, compared to 2 (4%) after multi‐disciplinary team discussion. Receipt of chemotherapy correlated with final margin status as determined by MDTB, not with initial main specimen margins (p = .02 and p = .08, respectively). With a median follow up of 28.4 months, two subjects (4%) had loco‐regional recurrence. Conclusion Following TORS, there was a significant discrepancy between status of margins as reported by the pathologist versus as determined by MDTB review. Chemotherapy was avoided in 93.1% of cases that were originally reported as positive margins by the pathologist with an acceptably low recurrence rate. Level of evidence 4.https://doi.org/10.1002/lio2.1163head and neck cancermarginsmargin statusoropharyngeal squamous cell carcinomarobotic surgeryTORS |
| spellingShingle | Aarthi Parvathaneni Sapna A. Patel Jeffrey J. Houlton John Pang Neal D. Futran Clarification of the margin status by the multidisciplinary tumor board following transoral robotic surgery for p16 positive oropharyngeal squamous cell carcinoma Laryngoscope Investigative Otolaryngology head and neck cancer margins margin status oropharyngeal squamous cell carcinoma robotic surgery TORS |
| title | Clarification of the margin status by the multidisciplinary tumor board following transoral robotic surgery for p16 positive oropharyngeal squamous cell carcinoma |
| title_full | Clarification of the margin status by the multidisciplinary tumor board following transoral robotic surgery for p16 positive oropharyngeal squamous cell carcinoma |
| title_fullStr | Clarification of the margin status by the multidisciplinary tumor board following transoral robotic surgery for p16 positive oropharyngeal squamous cell carcinoma |
| title_full_unstemmed | Clarification of the margin status by the multidisciplinary tumor board following transoral robotic surgery for p16 positive oropharyngeal squamous cell carcinoma |
| title_short | Clarification of the margin status by the multidisciplinary tumor board following transoral robotic surgery for p16 positive oropharyngeal squamous cell carcinoma |
| title_sort | clarification of the margin status by the multidisciplinary tumor board following transoral robotic surgery for p16 positive oropharyngeal squamous cell carcinoma |
| topic | head and neck cancer margins margin status oropharyngeal squamous cell carcinoma robotic surgery TORS |
| url | https://doi.org/10.1002/lio2.1163 |
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