QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency

QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency

<i>O</i><sup>6</sup>-methylguanine-DNA methyltransferase (MGMT) constitutes an important cellular mechanism for repairing potentially cytotoxic DNA damage induced by guanine <i>O</i><sup>6</sup>-alkylating agents and can render cells highly resistant t...

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Bibliographic Details
Main Authors: Guohui Sun, Peiying Bai, Tengjiao Fan, Lijiao Zhao, Rugang Zhong, R. Stanley McElhinney, T. Brian H. McMurry, Dorothy J. Donnelly, Joan E. McCormick, Jane Kelly, Geoffrey P. Margison
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceutics
Subjects:
MGMT
pseudosubstrates
inactivating agents
methyltransferase assay
MGMT activity determination
QSAR
Online Access:https://www.mdpi.com/1999-4923/15/8/2170

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