Electrochemical Sensing of Favipiravir with an Innovative Water-Dispersible Molecularly Imprinted Polymer Based on the Bimetallic Metal-Organic Framework: Comparison of Morphological Effects
Molecularly imprinted polymers (MIPs) are widely used as modifiers in electrochemical sensors due to their high sensitivity and promise of inexpensive mass manufacturing. Here, we propose and demonstrate a novel MIP-sensor that can measure the electrochemical activity of favipiravir (FAV) as an anti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/12/9/769 |
| _version_ | 1797490565172953088 |
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| author | Nevin Erk Mohammad Mehmandoust Mustafa Soylak |
| author_facet | Nevin Erk Mohammad Mehmandoust Mustafa Soylak |
| author_sort | Nevin Erk |
| collection | DOAJ |
| description | Molecularly imprinted polymers (MIPs) are widely used as modifiers in electrochemical sensors due to their high sensitivity and promise of inexpensive mass manufacturing. Here, we propose and demonstrate a novel MIP-sensor that can measure the electrochemical activity of favipiravir (FAV) as an antiviral drug, thereby enabling quantification of the concentration of FAV in biological and river water samples and in real-time. MOF nanoparticles’ application with various shapes to determine FAV at nanomolar concentrations was described. Two different MOF nanoparticle shapes (dodecahedron and sheets) were systematically compared to evaluate the electrochemical performance of FAV. After carefully examining two different morphologies of MIP-Co-Ni@MOF, the nanosheet form showed a higher performance and efficiency than the nanododecahedron. When MIP-Co/Ni@MOF-based and NIP-Co/Ni@MOF electrodes (nanosheets) were used instead, the minimum target concentrations detected were 7.5 × 10<sup>−11</sup> (MIP-Co-Ni@MOF) and 8.17 × 10<sup>−9</sup> M (NIP-Co-Ni@MOF), respectively. This is a significant improvement (>10<sup>2</sup>), which is assigned to the large active surface area and high fraction of surface atoms, increasing the amount of greater analyte adsorption during binding. Therefore, water-dispersible MIP-Co-Ni@MOF nanosheets were successfully applied for trace-level determination of FAV in biological and water samples. Our findings seem to provide useful guidance in the molecularly imprinted polymer design of MOF-based materials to help establish quantitative rules in designing MOF-based sensors for point of care (POC) systems. |
| first_indexed | 2024-03-10T00:34:48Z |
| format | Article |
| id | doaj.art-d48b76360b784e45a5fa71ecfae9662b |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-10T00:34:48Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-d48b76360b784e45a5fa71ecfae9662b2023-11-23T15:18:50ZengMDPI AGBiosensors2079-63742022-09-0112976910.3390/bios12090769Electrochemical Sensing of Favipiravir with an Innovative Water-Dispersible Molecularly Imprinted Polymer Based on the Bimetallic Metal-Organic Framework: Comparison of Morphological EffectsNevin Erk0Mohammad Mehmandoust1Mustafa Soylak2Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara 06560, TurkeyDepartment of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara 06560, TurkeyDepartment of Chemistry, Faculty of Sciences, Erciyes University, Kayseri 38039, TurkeyMolecularly imprinted polymers (MIPs) are widely used as modifiers in electrochemical sensors due to their high sensitivity and promise of inexpensive mass manufacturing. Here, we propose and demonstrate a novel MIP-sensor that can measure the electrochemical activity of favipiravir (FAV) as an antiviral drug, thereby enabling quantification of the concentration of FAV in biological and river water samples and in real-time. MOF nanoparticles’ application with various shapes to determine FAV at nanomolar concentrations was described. Two different MOF nanoparticle shapes (dodecahedron and sheets) were systematically compared to evaluate the electrochemical performance of FAV. After carefully examining two different morphologies of MIP-Co-Ni@MOF, the nanosheet form showed a higher performance and efficiency than the nanododecahedron. When MIP-Co/Ni@MOF-based and NIP-Co/Ni@MOF electrodes (nanosheets) were used instead, the minimum target concentrations detected were 7.5 × 10<sup>−11</sup> (MIP-Co-Ni@MOF) and 8.17 × 10<sup>−9</sup> M (NIP-Co-Ni@MOF), respectively. This is a significant improvement (>10<sup>2</sup>), which is assigned to the large active surface area and high fraction of surface atoms, increasing the amount of greater analyte adsorption during binding. Therefore, water-dispersible MIP-Co-Ni@MOF nanosheets were successfully applied for trace-level determination of FAV in biological and water samples. Our findings seem to provide useful guidance in the molecularly imprinted polymer design of MOF-based materials to help establish quantitative rules in designing MOF-based sensors for point of care (POC) systems.https://www.mdpi.com/2079-6374/12/9/769COVID-19favipiravir sensingmolecularly imprinted polymerCo/Ni metal–organic framework |
| spellingShingle | Nevin Erk Mohammad Mehmandoust Mustafa Soylak Electrochemical Sensing of Favipiravir with an Innovative Water-Dispersible Molecularly Imprinted Polymer Based on the Bimetallic Metal-Organic Framework: Comparison of Morphological Effects Biosensors COVID-19 favipiravir sensing molecularly imprinted polymer Co/Ni metal–organic framework |
| title | Electrochemical Sensing of Favipiravir with an Innovative Water-Dispersible Molecularly Imprinted Polymer Based on the Bimetallic Metal-Organic Framework: Comparison of Morphological Effects |
| title_full | Electrochemical Sensing of Favipiravir with an Innovative Water-Dispersible Molecularly Imprinted Polymer Based on the Bimetallic Metal-Organic Framework: Comparison of Morphological Effects |
| title_fullStr | Electrochemical Sensing of Favipiravir with an Innovative Water-Dispersible Molecularly Imprinted Polymer Based on the Bimetallic Metal-Organic Framework: Comparison of Morphological Effects |
| title_full_unstemmed | Electrochemical Sensing of Favipiravir with an Innovative Water-Dispersible Molecularly Imprinted Polymer Based on the Bimetallic Metal-Organic Framework: Comparison of Morphological Effects |
| title_short | Electrochemical Sensing of Favipiravir with an Innovative Water-Dispersible Molecularly Imprinted Polymer Based on the Bimetallic Metal-Organic Framework: Comparison of Morphological Effects |
| title_sort | electrochemical sensing of favipiravir with an innovative water dispersible molecularly imprinted polymer based on the bimetallic metal organic framework comparison of morphological effects |
| topic | COVID-19 favipiravir sensing molecularly imprinted polymer Co/Ni metal–organic framework |
| url | https://www.mdpi.com/2079-6374/12/9/769 |
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