Fat mass and obesity-associated gene (FTO) is associated to eating disorders susceptibility and moderates the expression of psychopathological traits.
Eating Disorders (EDs) show a multifactorial etiopathogenesis including environmental, psychological and biological factors. In the present study, we propose a model of interactions between genetic vulnerability-represented by Fat Mass and Obesity-Associated (FTO) gene-and stable psychopathological...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5345831?pdf=render |
| _version_ | 1818974461539385344 |
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| author | Giovanni Castellini Marica Franzago Silvia Bagnoli Lorenzo Lelli Michela Balsamo Milena Mancini Benedetta Nacmias Valdo Ricca Sandro Sorbi Ivana Antonucci Liborio Stuppia Giovanni Stanghellini |
| author_facet | Giovanni Castellini Marica Franzago Silvia Bagnoli Lorenzo Lelli Michela Balsamo Milena Mancini Benedetta Nacmias Valdo Ricca Sandro Sorbi Ivana Antonucci Liborio Stuppia Giovanni Stanghellini |
| author_sort | Giovanni Castellini |
| collection | DOAJ |
| description | Eating Disorders (EDs) show a multifactorial etiopathogenesis including environmental, psychological and biological factors. In the present study, we propose a model of interactions between genetic vulnerability-represented by Fat Mass and Obesity-Associated (FTO) gene-and stable psychopathological traits, such as bodily disorders and emotion dysregulation for EDs patients. The distribution of a polymorphism of the FTO (rs9939609 T>A) was evaluated in a series of 250 EDs patients and in a group of 119 healthy control subjects. Clinical data were collected through a face-to-face interview and several self-reported questionnaires were applied, including the Emotional Eating Scale and the IDentity and EAting disorders (IDEA) questionnaire for bodily disorders and self-identity. The A-allele was associated with an increased vulnerability to EDs (AA+AT genotypes frequency 72.8% in EDs vs. 52.9% in controls). The presence of the A-allele was associated with binge eating behavior, higher emotional eating and higher IDEA scores. Finally, the FTO rs9939609 SNP was found to influence the relationship between these variables, as an association between disorder of corporeality and emotional eating was found only in A-allele carriers. A-allele seems to represent a potential additive risk factor for EDs persons, with bodily disorders to develop emotional eating and binge eating behaviors. |
| first_indexed | 2024-12-20T15:40:26Z |
| format | Article |
| id | doaj.art-d48fdf2be4e14736aa0e65d0898d5104 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T15:40:26Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d48fdf2be4e14736aa0e65d0898d51042022-12-21T19:35:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01123e017356010.1371/journal.pone.0173560Fat mass and obesity-associated gene (FTO) is associated to eating disorders susceptibility and moderates the expression of psychopathological traits.Giovanni CastelliniMarica FranzagoSilvia BagnoliLorenzo LelliMichela BalsamoMilena ManciniBenedetta NacmiasValdo RiccaSandro SorbiIvana AntonucciLiborio StuppiaGiovanni StanghelliniEating Disorders (EDs) show a multifactorial etiopathogenesis including environmental, psychological and biological factors. In the present study, we propose a model of interactions between genetic vulnerability-represented by Fat Mass and Obesity-Associated (FTO) gene-and stable psychopathological traits, such as bodily disorders and emotion dysregulation for EDs patients. The distribution of a polymorphism of the FTO (rs9939609 T>A) was evaluated in a series of 250 EDs patients and in a group of 119 healthy control subjects. Clinical data were collected through a face-to-face interview and several self-reported questionnaires were applied, including the Emotional Eating Scale and the IDentity and EAting disorders (IDEA) questionnaire for bodily disorders and self-identity. The A-allele was associated with an increased vulnerability to EDs (AA+AT genotypes frequency 72.8% in EDs vs. 52.9% in controls). The presence of the A-allele was associated with binge eating behavior, higher emotional eating and higher IDEA scores. Finally, the FTO rs9939609 SNP was found to influence the relationship between these variables, as an association between disorder of corporeality and emotional eating was found only in A-allele carriers. A-allele seems to represent a potential additive risk factor for EDs persons, with bodily disorders to develop emotional eating and binge eating behaviors.http://europepmc.org/articles/PMC5345831?pdf=render |
| spellingShingle | Giovanni Castellini Marica Franzago Silvia Bagnoli Lorenzo Lelli Michela Balsamo Milena Mancini Benedetta Nacmias Valdo Ricca Sandro Sorbi Ivana Antonucci Liborio Stuppia Giovanni Stanghellini Fat mass and obesity-associated gene (FTO) is associated to eating disorders susceptibility and moderates the expression of psychopathological traits. PLoS ONE |
| title | Fat mass and obesity-associated gene (FTO) is associated to eating disorders susceptibility and moderates the expression of psychopathological traits. |
| title_full | Fat mass and obesity-associated gene (FTO) is associated to eating disorders susceptibility and moderates the expression of psychopathological traits. |
| title_fullStr | Fat mass and obesity-associated gene (FTO) is associated to eating disorders susceptibility and moderates the expression of psychopathological traits. |
| title_full_unstemmed | Fat mass and obesity-associated gene (FTO) is associated to eating disorders susceptibility and moderates the expression of psychopathological traits. |
| title_short | Fat mass and obesity-associated gene (FTO) is associated to eating disorders susceptibility and moderates the expression of psychopathological traits. |
| title_sort | fat mass and obesity associated gene fto is associated to eating disorders susceptibility and moderates the expression of psychopathological traits |
| url | http://europepmc.org/articles/PMC5345831?pdf=render |
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