Possible mechanisms of hypotension produced 70% alcoholic extract of <it>Terminalia arjuna </it>(L.) in anaesthetized dogs
<p>Abstract</p> <p>Background</p> <p>The bark of Terminalia arjuna L. (Combretaceae) is used in Ayurveda since ancient times for the treatment of cardiac disorders. Previous laboratory investigations have demonstrated the use of the bark in cardiovascular complications....
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| Format: | Article |
| Language: | English |
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BMC
2003-10-01
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| Series: | BMC Complementary and Alternative Medicine |
| Online Access: | http://www.biomedcentral.com/1472-6882/3/5 |
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| author | Lodagala Durga S Babu Behara S Ravindra Gudavalli Rambabu Nammi Srinivas Boini Krishna M |
| author_facet | Lodagala Durga S Babu Behara S Ravindra Gudavalli Rambabu Nammi Srinivas Boini Krishna M |
| author_sort | Lodagala Durga S |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The bark of Terminalia arjuna L. (Combretaceae) is used in Ayurveda since ancient times for the treatment of cardiac disorders. Previous laboratory investigations have demonstrated the use of the bark in cardiovascular complications. The present study was aimed to find the effect of 70% alcoholic extract of Terminalia arjuna on anaesthetized dog blood pressure and probable site of action.</p> <p>Methods</p> <p>Six dogs were anaesthetized with intraperitoneal injection of thiopental sodium and the blood pressure of each dog (n = 6) was measured from the left common carotid artery connected to a mercury manometer on kymograph. The femoral vein was cannulated for administration of drug solutions. The extract of <it>T. arjuna </it>(dissolved in propylene glycol) in the dose range of 5 to 15 mg/kg were administered intravenously in a pilot study and the dose (6 mg/kg) which produced appreciable hypotension was selected for further studies.</p> <p>Results</p> <p>Intravenous administration of <it>T. arjuna </it>produced dose-dependent hypotension in anaesthetized dogs. The hypotension produced by 6 mg/kg dose of the extract was blocked by propranolol but not by atropine or mepyramine maleate. This indicates that muscarinic or histaminergic mechanisms are not likely to be involved in the hypotension produced by the extract. The blockade by propranolol of the hypotension produced by <it>T. arjuna </it>indicates that the extract might contain active compound(s) possessing adrenergic ß<sub>2</sub>-receptor agonist action and/or that act directly on the heart muscle.</p> <p>Conclusion</p> <p>The results indicated the likely involvement of peripheral mechanism for hypotension produced by the 70% alcoholic extract of <it>Terminalia arjuna </it>and lends support for the claims of its traditional usage in cardiovascular disorders.</p> |
| first_indexed | 2024-12-21T08:53:41Z |
| format | Article |
| id | doaj.art-d4901ba7b7dc4c859c153b7d81014454 |
| institution | Directory Open Access Journal |
| issn | 1472-6882 |
| language | English |
| last_indexed | 2024-12-21T08:53:41Z |
| publishDate | 2003-10-01 |
| publisher | BMC |
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| series | BMC Complementary and Alternative Medicine |
| spelling | doaj.art-d4901ba7b7dc4c859c153b7d810144542022-12-21T19:09:37ZengBMCBMC Complementary and Alternative Medicine1472-68822003-10-01315Possible mechanisms of hypotension produced 70% alcoholic extract of <it>Terminalia arjuna </it>(L.) in anaesthetized dogsLodagala Durga SBabu Behara S RavindraGudavalli RambabuNammi SrinivasBoini Krishna M<p>Abstract</p> <p>Background</p> <p>The bark of Terminalia arjuna L. (Combretaceae) is used in Ayurveda since ancient times for the treatment of cardiac disorders. Previous laboratory investigations have demonstrated the use of the bark in cardiovascular complications. The present study was aimed to find the effect of 70% alcoholic extract of Terminalia arjuna on anaesthetized dog blood pressure and probable site of action.</p> <p>Methods</p> <p>Six dogs were anaesthetized with intraperitoneal injection of thiopental sodium and the blood pressure of each dog (n = 6) was measured from the left common carotid artery connected to a mercury manometer on kymograph. The femoral vein was cannulated for administration of drug solutions. The extract of <it>T. arjuna </it>(dissolved in propylene glycol) in the dose range of 5 to 15 mg/kg were administered intravenously in a pilot study and the dose (6 mg/kg) which produced appreciable hypotension was selected for further studies.</p> <p>Results</p> <p>Intravenous administration of <it>T. arjuna </it>produced dose-dependent hypotension in anaesthetized dogs. The hypotension produced by 6 mg/kg dose of the extract was blocked by propranolol but not by atropine or mepyramine maleate. This indicates that muscarinic or histaminergic mechanisms are not likely to be involved in the hypotension produced by the extract. The blockade by propranolol of the hypotension produced by <it>T. arjuna </it>indicates that the extract might contain active compound(s) possessing adrenergic ß<sub>2</sub>-receptor agonist action and/or that act directly on the heart muscle.</p> <p>Conclusion</p> <p>The results indicated the likely involvement of peripheral mechanism for hypotension produced by the 70% alcoholic extract of <it>Terminalia arjuna </it>and lends support for the claims of its traditional usage in cardiovascular disorders.</p>http://www.biomedcentral.com/1472-6882/3/5 |
| spellingShingle | Lodagala Durga S Babu Behara S Ravindra Gudavalli Rambabu Nammi Srinivas Boini Krishna M Possible mechanisms of hypotension produced 70% alcoholic extract of <it>Terminalia arjuna </it>(L.) in anaesthetized dogs BMC Complementary and Alternative Medicine |
| title | Possible mechanisms of hypotension produced 70% alcoholic extract of <it>Terminalia arjuna </it>(L.) in anaesthetized dogs |
| title_full | Possible mechanisms of hypotension produced 70% alcoholic extract of <it>Terminalia arjuna </it>(L.) in anaesthetized dogs |
| title_fullStr | Possible mechanisms of hypotension produced 70% alcoholic extract of <it>Terminalia arjuna </it>(L.) in anaesthetized dogs |
| title_full_unstemmed | Possible mechanisms of hypotension produced 70% alcoholic extract of <it>Terminalia arjuna </it>(L.) in anaesthetized dogs |
| title_short | Possible mechanisms of hypotension produced 70% alcoholic extract of <it>Terminalia arjuna </it>(L.) in anaesthetized dogs |
| title_sort | possible mechanisms of hypotension produced 70 alcoholic extract of it terminalia arjuna it l in anaesthetized dogs |
| url | http://www.biomedcentral.com/1472-6882/3/5 |
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