Expression and Clinical Significance of Activating Transcription Factor 3 in Human Breast Cancer
Objective(s): Breast cancer is the most common type of cancer among women worldwide. This study investigated the expression and clinical significance of activating transcription factor 3 (ATF3) in human breast cancer and its relationship with the clinical outcome of breast cancer. Materials and...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2013-11-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/pdf_1932_3d82c7ef9d5d35c9c4b83e0fac9ae4ef.html |
| _version_ | 1811267159927554048 |
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| author | Hua Cao Guo-Qin Jiang |
| author_facet | Hua Cao Guo-Qin Jiang |
| author_sort | Hua Cao |
| collection | DOAJ |
| description | Objective(s):
Breast cancer is the most common type of cancer among women worldwide. This study investigated the expression and clinical significance of activating transcription factor 3 (ATF3) in human breast cancer and its relationship with the clinical outcome of breast cancer.
Materials and Methods
: ATF3 expressions were detected in 114 primary breast cancer tissues and 114 adjacent normal tissues using immunohistochemistry (IHC) assay. Categorical variables were statistically compared by chi-square or Fisher’s exact test. Survival curves were evaluated using the Kaplan-Meier method and comparisons of survival rates were tested using a Log-rank test.
Results
: IHC analysis showed that the positive expression of ATF3 protein was detected in breast cancer tissue with a positive ratio of 76.3%, and the positive ATF3 expression in adjacent normal breast tissue was 13.2%, which is lower than that in breast cancer tissue samples (P0.05). A significant difference in overall survival rate was found between the patients with positive expression of ATF3 protein and those with negative expression (P=0.041).
Conclusion
: Increased ATF3 expression participate in the tumorigenesis, invasion and metastasis of breast cancer, and ATF3 may be useful as a new prognostic indicator for breast cancer patients |
| first_indexed | 2024-04-12T20:56:19Z |
| format | Article |
| id | doaj.art-d49068dd0edd4bcc887f6e4eb86b1d50 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-12T20:56:19Z |
| publishDate | 2013-11-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-d49068dd0edd4bcc887f6e4eb86b1d502022-12-22T03:16:59ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742013-11-011611115111541932Expression and Clinical Significance of Activating Transcription Factor 3 in Human Breast CancerHua Cao0Guo-Qin Jiang1Department of General Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of General Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaObjective(s): Breast cancer is the most common type of cancer among women worldwide. This study investigated the expression and clinical significance of activating transcription factor 3 (ATF3) in human breast cancer and its relationship with the clinical outcome of breast cancer. Materials and Methods : ATF3 expressions were detected in 114 primary breast cancer tissues and 114 adjacent normal tissues using immunohistochemistry (IHC) assay. Categorical variables were statistically compared by chi-square or Fisher’s exact test. Survival curves were evaluated using the Kaplan-Meier method and comparisons of survival rates were tested using a Log-rank test. Results : IHC analysis showed that the positive expression of ATF3 protein was detected in breast cancer tissue with a positive ratio of 76.3%, and the positive ATF3 expression in adjacent normal breast tissue was 13.2%, which is lower than that in breast cancer tissue samples (P0.05). A significant difference in overall survival rate was found between the patients with positive expression of ATF3 protein and those with negative expression (P=0.041). Conclusion : Increased ATF3 expression participate in the tumorigenesis, invasion and metastasis of breast cancer, and ATF3 may be useful as a new prognostic indicator for breast cancer patientshttp://ijbms.mums.ac.ir/pdf_1932_3d82c7ef9d5d35c9c4b83e0fac9ae4ef.htmlActivating transcription factor 3 (ATF3) Breast cancer Clinical significance Immunohistochemistry Prognostic indicator |
| spellingShingle | Hua Cao Guo-Qin Jiang Expression and Clinical Significance of Activating Transcription Factor 3 in Human Breast Cancer Iranian Journal of Basic Medical Sciences Activating transcription factor 3 (ATF3) Breast cancer Clinical significance Immunohistochemistry Prognostic indicator |
| title | Expression and Clinical Significance of Activating Transcription Factor 3 in Human Breast Cancer |
| title_full | Expression and Clinical Significance of Activating Transcription Factor 3 in Human Breast Cancer |
| title_fullStr | Expression and Clinical Significance of Activating Transcription Factor 3 in Human Breast Cancer |
| title_full_unstemmed | Expression and Clinical Significance of Activating Transcription Factor 3 in Human Breast Cancer |
| title_short | Expression and Clinical Significance of Activating Transcription Factor 3 in Human Breast Cancer |
| title_sort | expression and clinical significance of activating transcription factor 3 in human breast cancer |
| topic | Activating transcription factor 3 (ATF3) Breast cancer Clinical significance Immunohistochemistry Prognostic indicator |
| url | http://ijbms.mums.ac.ir/pdf_1932_3d82c7ef9d5d35c9c4b83e0fac9ae4ef.html |
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